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Environmental Assessment

IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (2010 Final)

Notice

EPA announces the release of the final report, Toxicological Review of Hydrogen Cyanide and Cyanide Salts (CAS No. various): In Support of Summary Information on the Integrated Risk Information System (IRIS).

Report Information

Cyanide compounds are used in a number of industrial processes including mining, electroplating, metallurgy, chemical manufacturing, and photography because these compounds can form stable complexes with a range of metals. Hydrogen cyanide is also a component of tobacco smoke, vehicle exhaust, and is produced by the burning of some plastics. Cyanide salts, such as potassium and sodium cyanide, are also used as rodenticides.

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Kathleen Newhouse
  • by phone at:   703-347-8641
  • by email at:  newhouse.kathleen@epa.gov

History/Chronology

Jan 1987EPA posted an assessment for cyanide salts (RfD only).
Sep 1994EPA posted an assessment for hydrogen cyanide (RfC only).
Sep 2009EPA released the external draft report for public review and comment.
Oct 2009EPA announced a public listening session to be held on October 27, 2009. [Federal Register Notice Sep 23, 2009]
Nov 2009EPA announced an external peer review workshop to be held on December 14, 2009. [Federal Register Notice Nov 10, 2009]
Sep 2010EPA released the final tox report and summary document and posted these to the IRIS web site.
Jun 2004The draft IRIS reassessment of hydrogen cyanide was started.
Jan 2010EPA released the comments from the public comment period and external review workshop.
Aug 2010EPA hosted an interagency science discussion on the review of the draft document.
Sep 2010EPA released the final toxicological report and IRIS Summary for Hydrogen Cyanide and the interagency review draft with comments.

Citation

U.S. EPA. IRIS Toxicological Review of Hydrogen Cyanide and Cyanide Salts (2010 Final). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-08/016F, 2010.

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