IRIS Toxicological Review of Inorganic Arsenic (Cancer) (2010 External Review Draft)
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EPA's Science Advisory Board (SAB) conducted a review of the scientific basis supporting the human health cancer hazard and dose-response assessment of inorganic arsenic that will appear on the Integrated Risk Information System (IRIS) database. EPA revised the assessment and is now returning the assessment to the SAB and releasing the document to the public for a focused review of EPA's responses to the SAB recommendations. Please refer to IRISTrack - Inorganic Arsenic (Cancer) for the latest schedule updates.
|1999||NRC reviews the 1988 IRIS assessment and the available health data for inorganic arsenic and makes recommendations for updating the cancer assessment.|
|2001||NRC updated the NRC (1999) report and evaluated the toxicological risk and health effects of arsenic as relevant to the 2001 Arsenic Rule.|
|2001||NRC reviews the 2001 Primary Drinking Water Standard for inorganic Arsenic and EPA’s supporting risk assessment and makes recommendations for applying epidemiologic data in the cancer health assessment.|
|2003||EPA started a reassessment of the IRIS assessment for inorganic arsenic.|
|Jul 2005||EPA submitted the reassessment of cancer assessment for inorganic arsenic to EPA’s Science Advisory Board (SAB) for review (see related links under downloads).|
|Jun 2007||SAB posted a response to the 2005 EPA reassessment of inorganic arsenic (cancer). [See related links (below) or Link to the SAB Report and Review Panel Meetings]|
|Oct 2008||The draft IRIS Toxicological Review for Inorganic Arsenic (cancer) was submitted to OMB for interagency review.|
|Feb 2010||EPA released the draft IRIS Toxicological Review for Inorganic Arsenic (cancer) to SAB and simultaneously to the public for review and comment, focusing on EPA’s responses to the SAB (2007) report.|
|Oct 2010||SAB announced a public teleconference to conduct a quality review of the draft report to be held on November 22, 2010. [Federal Register Oct 25, 2010]|
Supporting Documents: The file, Arsenic_Excel_Table 5-3.zip (ZIP, 195 Kb), provides the data and analyses EPA used to derive the cancer risk estimates as described in Table 5-3 in the Toxicological Review of Inorganic Arsenic (Cancer) (External Review Draft) 2010. An additional file (Arsenic_Excel_Appendix F.zip (ZIP, 143 Kb), ) provides the data and analyses EPA used to derive the results presented in Appendix F (Tables F-1 and F-2). Information regarding the files can be found on the first tab (labeled Directions) of each individual Excel® file.
This download(s) is distributed solely for the purpose of pre-dissemination peer review under applicable information quality guidelines. It has not been formally disseminated by EPA. It does not represent and should not be construed to represent any Agency determination or policy.
- (88 pp, 433 KB, about PDF)
- (114 pp, 6 MB, about PDF)
- IRIS Toxicological Review of Ingested Inorganic Arsenic (SAB External Review Draft)