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IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft)
Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.
Contact
- Karen A. Hammerstrom
- by phone at: 703-347-8642
- by email at: hammerstrom.karen@epa.gov
Notice
As per the May 21, 2009, IRIS process, all comments received from federal agencies and White House offices on draft IRIS assessments will be made publicly available. Accordingly, interagency comments and the interagency draft of the 1,2,3-Trichloropropane IRIS assessment have been posted on this site.
On September 30, 2009, the IRIS Summary and Toxicological Review of 1,2,3-trichloropropane (TCP) was finalized and loaded onto the IRIS database. The Toxicological Review of TCP was reviewed internally by EPA, by other federal agencies and White House Offices, by expert external peer reviewers, and by the public. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCP IRIS assessment are posted on this site.Background
The draft Toxicological Review of 1,2,3-Trichloropropane provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to chronic exposure to 1,2,3-trichloropropane. 1,2,3-Trichloropropane is an important industrial chemical used as a solvent for oils and fats, waxes, and resins, and has also been used in paint thinner and varnish remover and as a degreasing agent. 1,2,3-Trichloropropane is also generated as a by-product of the production of other chlorinated compounds such as epichlorohydrin, and is used as an intermediate in the production of some pesticides and polymers, such as polysulfide rubbers.
This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.
This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.
History/Chronology
| 2003 | EPA began developing the Toxicological Review of 1,2,3-trichloropropane. |
| Nov 2007 | EPA released an External Review Draft for public comment and review. |
| Jan 2008 | EPA announced the external peer review panel meeting in a Jan 18, 2008 Federal Register Notice. |
| Sep 2009 | EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of 1,2,3-trichloropropane. These comments are provided on this web site. |
| Sep 2009 | EPA released the Final Toxicological Review (PDF) (247 pp, 1.9M) and accompanying Summary for 1,2,3-Trichloropropane to the IRIS Web site. |
Next Steps
The assessment has been finalized and loaded onto the IRIS database.
Downloads/Related Links
- Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft) (PDF) (254 pp, 1 MB, about PDF)
- IRIS Summary for 1,2,3-Trichloropropane (Interagency Science Discussion Draft) (PDF) (26 pp, 128 KB, about PDF)
- OMB Comments for the IRIS Summary and Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Drafts) (PDF) (4 pp, 34 KB, about PDF)
Related Link(s)
Citation
U.S. EPA. IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft). U.S. Environmental Protection Agency, Washington, D.C., 2009.
