IRIS Toxicological Review of 1,2,3-Trichloropropane (Interagency Science Discussion Draft)
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On September 30, 2009, the IRIS Summary and Toxicological Review of 1,2,3-trichloropropane (TCP) was finalized and loaded onto the IRIS database. The Toxicological Review of TCP was reviewed internally by EPA, by other federal agencies and White House Offices, by expert external peer reviewers, and by the public. In the new IRIS process, introduced by the EPA Administrator, all written comments on IRIS assessments submitted by other federal agencies and White House Offices will be made publicly available. Accordingly, interagency comments and the interagency draft of the TCP IRIS assessment are posted on this site.
This assessment contains the derivation of a chronic reference dose and a chronic reference concentration, as well as a cancer characterization and the derivation of an oral slope factor.
|2003||EPA began developing the Toxicological Review of 1,2,3-trichloropropane.|
|Nov 2007||EPA released an External Review Draft for public comment and review.|
|Jan 2008||EPA announced the external peer review panel meeting in a Jan 18, 2008 Federal Register Notice.|
|Sep 2009||EPA hosted an interagency science discussion on the review of the draft IRIS Summary and Toxicological Review of 1,2,3-trichloropropane. These comments are provided on this web site.|
|Sep 2009||EPA released the Final Toxicological Review (PDF) (247 pp, 1.9M) and accompanying Summary for 1,2,3-Trichloropropane to the IRIS Web site.|