Environmental Assessment
IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (2010 Final Report)
Report Information
EPA is announcing the release of the final report, Toxicological Review of 1,1,2,2-Tetrachloroethane: in support of the Integrated Risk Information System (IRIS). The updated Summary for 1,1,2,2-Tetrachloroethane and accompanying Quickview have also been added to the IRIS Database.
Martin Gehlhaus
- by phone at: 703-347-8579
- by email at: gehlhaus.martin@epa.gov
Background
The Toxicological Review of 1,1,2,2-tetrachloroethane provides scientific support and rationale for the hazard and dose-response assessment pertaining to subchronic and chronic exposure to 1,1,2,2-tetrachloroethane. 1,1,2,2 Tetrachloroethane (1,1,2,2TCE; CASRN 79-34-5) is a synthetic halogenated hydrocarbon that is a colorless, nonflammable liquid at room temperature. The major use for 1,1,2,2 tetrachloroethane was in the production of trichloroethylene, tetrachloroethylene, and 1,2-dichloroethylene. This assessment contains the derivation of both a subchronic and chronic reference dose and an oral cancer slope factor. EPA is also putting forth for external review the statement that the human carcinogenic potential of 1,1,2,2-tetrachloroethane is “likely to be carcinogenic to humans”.
History/Chronology
| September 2010 | EPA released the final tox report and summary document and posted these to the IRIS database. |
Citation
U.S. EPA. IRIS Toxicological Review of 1,1,2,2-Tetrachloroethane (2010 Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-09/001, 2010.