Environmental Assessment
IRIS Toxicological Review of Thallium and Compounds (External Review Draft)
IRIS Toxicological Review of Thallium and Compounds (External Review Draft)
Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.
Federal Register Notices
Contacts
- Send an Email
- by email at: webmaster.risk@epa.gov
Notice
In April 2008, EPA has announced the External Peer Review Panel Workshop in an April 8, 2008 Federal Register notice. Prior to this, EPA announces the release of the Toxicological Review of Thallium in a Feb 15, 2008 Federal Register notice. This draft assessment was provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN were provided to the external peer reviewers for their consideration. Any comments not received within the requested time period may be considered by EPA in their revisions. The date and location of the external peer review meeting were provided in a separate announcement.
Thallium compounds are used in the semiconductor industry, the manufacture of optic lenses and low-melting glass, low-temperature thermometers, alloys, electronic devices, mercury lamps, fireworks, and imitation germs, and clinically as an imaging agent in the diagnosis of certain tumors. EPA's assessment of noncancer health effects and carcinogenic potential of thallium compounds was last prepared and added to the IRIS database between 1988 and 1990. The IRIS program is preparing an assessment that will incorporate current health effects information available for thallium and compounds, and current risk assessment methods. The IRIS assessment for thallium compounds will consist of a Toxicological Review and IRIS Summary. The Toxicological Review is a critical review of the physiochemical and toxicokinetic properties of a chemical, and its toxicity in humans and experimental systems. The assessment will present reference values for the noncancer effects of thallium compounds (RfD and Rfc), and a cancer assessment. The Toxicological Review and IRIS Summary have been subject to Agency review, Interagency review, and external scientific peer review. The final product will reflect the Agency opinion on the overall toxicity of thallium and compounds.Background
History/Chronology
1987 | IRIS assessments of thallium acetate, carbonate, chloride, nitrate, selenite, and sulfate, and thallic oxide posted on the IRIS database (RfD only). |
1988 | RfDs for thallium compounds revised. |
1989 | RfD for thallic oxide withdrawn from the IRIS database. |
1990 | Carcinogenicity assessments for thallium compounds added to the IRIS database. |
1993 | RfD for thallium selenite withdrawn from the IRIS database. |
Feb 2008 | EPA releases the draft document, IRIS Toxicological Review of Thallium, for public review and comment in a February 15, 2008 Federal Register notice. |
Apr 2008 | EPA announces the external peer review panel workshop in an April 8, 2008 Federal Register notice. |
Sep 2009 | EPA released the Final Toxicological Review (PDF) (136 pp, 964K) and accompanying Summary for Thallium and Compounds to the IRIS Web site. |
Next Steps
Downloads/Related Links
- Toxicological Review of Thallium (External Review Draft) (PDF) (86 pp, 474 KB, about PDF)
- Charge to External Peer Reviewers (PDF) (3 pp, 21 KB, about PDF)
- Consolidated Comments from the External Peer Review (Final) (PDF) (76 pp, 257 KB, about PDF)
Related Link(s)
- Compilation of Reviewer Comments and Responses to Charge Questions (Reported By Midwest Research Institute) (PDF) (10 pp, 43 KB, about PDF)
- Volume 1: Range Finding (14-Day Study) (PDF) (55 pp, 29 MB, about PDF)
- Volume 2: Range Finding (90-Day Study) Part 1 (PDF) (299 pp, 57 MB, about PDF)
- Volume 2: Range Finding Part 2 (Appendix IV) (PDF) (255 pp, 150 MB, about PDF)
- IRIS Toxicological Review of Thallium and Compounds (Final Report)
Additional Information
Contact Information
Octavia Conerlyby phone at: 202-566-1094
by fax at: 202-566-1140
by email at: conerly.octavia@epa.gov
Susan Rieth
by phone at: 703-347-8582
by fax at: 703-347-8699
by email at: rieth.susan@epa.gov
Citation