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Environmental Assessment

IRIS Toxicological Review of Acrylamide (External Review Draft)

IRIS Toxicological Review of Acrylamide (External Review Draft)

Note: EPA has updated this document, but this version is provided as a courtesy to the public as a matter of public record.


Contacts
Robert Dewoskin
by phone at:   919-541-1089
by email at:  dewoskin.rob@epa.gov

Notice

In December 2007, EPA released the draft report,Toxicological Review for Acrylamide, for public comment and external peer review (step 5 of the IRIS Assessment Development Process. EPA's Science Advisory Board (SAB) conducted the peer review which was previously announced in a February 1, 2008 Federal Register Notice. Subsequent to the SAB review, an external letter peer consultation of methodology used to derive the internal dose was conducted. The report from this review is now available.

EPA has conducted a peer review by EPA’s Science Advisory Board (SAB) of the scientific basis supporting the human health hazard and dose-response assessment of acrylamide that once finalized will appear on the Integrated Risk Information System (IRIS) database. Peer review is meant to ensure that the science is used credibly and appropriately in derivation of the dose-response assessments and toxicological characterization.
Background
The draft Toxicological Review of Acrylamide provides scientific support and rationale for the hazard identification and dose-response assessment pertaining to a chronic exposure to acrylamide.

Acrylamide is a chemical used in the production of polyacrylamide polymers. Polyacrylamides are used as a flocculent in water purification, oil recovery, and soil conditioning and stabilization. Other uses include paper making, adhesion-promotion, dye acceptors, and textile additives. Human exposure to acrylamide had been thought to occur primarily in the workplace from dermal contact and inhalation of dust and vapor, with the general public being potentially exposed to low levels of acrylamide primarily through contaminated drinking water.

In addition, the draft toxicological review notes that cigarette smoke (direct and secondary) is another exposure route. In early 2002, Swedish scientists reported high concentrations of acrylamide in certain fried, baked, and deep-fried foods. Subsequent research demonstrated that acrylamide forms de novo during processing of some foods, especially during high temperature cooking of carbohydrate-rich foods that contain asparagine.

This assessment contains the derivation of a chronic reference dose (RfD) and a chronic reference concentration (RfC) for non-cancer effects, as well as an oral slope factor and an inhalation unit risk for carcinogenic effects.

History/Chronology

Jul 2004EPA completes the initial draft document for the Toxicological Review of Acrylamide.
Nov 2006EPA completes Internal Agency Review.
Nov 2007EPA completes Inter-Agency Review.
Dec 2007EPA releases the External Review Draft for public comment and review.
Feb 2008SAB announces in a February 1, 2008 Federal Register Notice a public teleconference to be held on Feb 20, 2008 with a face-to-face meeting March 10 -12, 2008.
Dec 2008SAB finalizes their review report of the Toxicological Review of Acrylamide.
Oct 2009EPA completes second Internal EPA and Interagency Review.
Jan 2010EPA completes external letter peer consultation of methodology used to derive the internal dose.
Mar 2010EPA releases the comments from the public comment period and external review workshop.

Next Steps

Following the External Peer Review, the final assessment will be published on the IRIS database.

Downloads/Related Links

Additional Information

Comments on the assessment may be submitted and reviewed using the e-Government Regulations.gov Web site. From the site, select Environmental Protection Agency and the key word EPA- HQ-ORD-2007-1141 (for the docket ID).

Citation

U.S. EPA. IRIS Toxicological Review of Acrylamide (External Review Draft). U.S. Environmental Protection Agency, Washington, DC, EPA/635/R-07/009A.

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