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Chemical safety decisions and management can be hindered by the lack of ready-access to the ever-expanding array of data, tools, and models that are relevant to the analyses. Even though many chemical safety resources are available, it may not be clear how the various sources of ...

It is estimated that over half of chemicals in commerce are classified as chemical substances of unknown or variable composition, complex reaction products and/or biological materials (UVCBs). Individual UVCBs are poorly defined at the chemical structure and weight fraction level...

Great Lakes coastal systems are vulnerable to introduction of a wide variety of non-indigenous species (NIS). Early-detection efforts have focused on a variety of strategies include conducting high-intensity sampling, deploying a wide range of sampling gear types, and performing ...

Household air pollution from the burning of solid fuels for cooking and heating is estimated to cause 2.9 million deaths annually. Cardiovascular-related disease is a substantial contributor to the burden although evidence is limited. We evaluated the cross-sectional association ...

The process of molting, known alternatively as ecdysis, is a feature integral within the life-cycles of species across the arthropod phylum. Regulation occurs as a function of the interaction of ecdysteroid hormones with the arthropod nuclear ecdysone receptor (EcR) and triggerin...

Affordable air sensors are revolutionizing how air quality is monitored. While many air sensor studies have focused on measurement accuracy and data correction, an important use of sensors is informing air quality action, since sensors can be deployed in dense networks that can c...

Modeling exposure and recovery of fish and wildlife populations after stressor mitigation serves as a basis for evaluating population status and remediation success. Herein, we develop a novel multidimensional density dependent matrix population model that analyzes both size-str...

Particulate air sensor performance is often evaluated at a single site or in a single region over a time period from weeks to a few months. However, sensor performance is typically dependent on environmental conditions, pollutant concentrations, and particle properties. In additi...

Interest in the performance and potential applications for air sensor technologies continues to grow and evolve rapidly. Interested stakeholders need access to timely information about the state of the science. This presentation gives a brief overview of EPA's current work on a...

Contamination of freshwater by multiple major ions is an issue of growing concern. An emerging Multi-Ion Toxicity (MIT) model for assessment of environmental salt pollution is based on the premise that major ion toxicity to aquatic organisms is related to a critical disturbance o...

For any single project, air sensor performance is typically evaluated at a single site or within a single region over a short time period (weeks to months). However, sensor performance often depends on environmental conditions, pollutant concentrations, and particle properties. I...

Mobile mapping of air pollution has the potential to provide pollutant concentration data at unprecedented spatial scales. Characterizing instrument performance in the mobile context is challenging, but necessary to analyze and interpret the resulting data. We used robust stati...

Environment and health challenges are pronounced in Asia, an exceptionally diverse and complex region where global megatrends are exemplified and numerous stresses to environmental quality exist. Because identifying priorities necessary to engage grand challenges can be facilita...

The Watershed Management Optimization Support Tool (WMOST) was developed by the United States Environmental Protection Agency (US EPA) to facilitate integrated water resources management. The new Benefits Module for WMOST enables stakeholders to calculate the value of additional ...

Reuse systems must produce water of consistent quality in order to ensure the protection of human health and the environment. In this study, several online real-time sensors and the CANARY event detection software were utilized to track the treatment performance of a wastewater f...

Greening America’s Communities is an EPA program, offered by the Office of Community Revitalization to help cities and towns develop an implementable vision of environmentally friendly neighborhoods that incorporate innovative green infrastructure and other sustainable design str...

New approach methodologies (NAMs) for hazard can be used to inform biological, weight-of-evidence questions as well as risk-related questions for a given substance or set of substances. In this training, a generic workflow using the CompTox Chemicals Dashboard as a data viewer an...

Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. To address this gap for toxicokinetics one can use in...

Exposure is a key component of chemical risk assessments, as highlighted by the recent amendment to the Toxic Substances Control Act mandating the US Environmental Protection Agency to consider conditions of chemical use, as well as human and ecological exposures across the chemi...

PubMed is the largest freely available source of published literature available online with access to well over 30 million citations. Contained within the literature is an abundance of information about the activity of chemicals in biological systems. Literature informatics appro...

The study was conducted in four phases, each using viable spores of Bacillus atrophaeus var. globigii (Bg), a surrogate for Ba. Phase I and II were part of a bench-scale study using a Lab Line Incubator-Orbital Shaker to simulate a washing machine. The experiment was conducted us...

Read-across is a well-established data gap filling technique used within analogue and category approaches. There are several steps in the category workflow starting from analogue identification, analogue evaluation, data gap filling through to uncertainty assessment. There are a ...

The primary objectives of this project research effort were to analyze the potential for application of an aggressive air sampling (AAS) technique for measurement of spores resulting from a dissemination of a biological agent, Bacillus anthracis (Ba), in an indoor environment and...

The CompTox Chemicals Dashboard, now in its 10th release, is the primary web application from the US EPA Center for Computational Toxicology & Exposure used to source data associated with ~880,000 chemicals. Physicochemical property and fate and transport data, in vitro high-...

These are challenging and exciting times for environmental science, molecular and computational toxicology. Advances in the biological and molecular sciences have instigated an ongoing paradigm shift in toxicity testing away from traditional, animal-based methods to in vitro and ...