EPA Science Inventory

Search Criteria: the term 'Perfluorochemicals OR Perfluoroalkyl OR Perfluorinated OR Polyfluorinated OR Polyfluoroalkyl OR pfas OR pfoa OR pfc OR pfos' in any part of any record.
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Records 1 to 25 of 508

Behavior and Fate of PFOA and PFOS in Sandy Aquifer Sediment (journal) (JOURNAL)
Microcosms were constructed with sediment from beneath a landfill that received waste containing PFOA (perfluorooctanoic acid) and PFOS (perfluorooctane sulfonate). The microcosms were amended with PFOA and PFOS, and sampled after 91, 210, 343, 463, 574, and 740 days of incubat...
Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPARa-knocked out and wild-type mice. (JOURNAL)
Perfluorooctanoic acid (PFOA) is an environmentally persistent chemical commonly found in humans and wildlife. Induction of liver tumors by PFOA in rodents is thought to be mediated by PPARα activation, although hepatic hypertrophy persists in PPARα-null mice. This study evalua...
Current Understanding of Perfluoroalkyl Acid Toxicology (PRESENTATION)
The perfluoroalkyl acids (PFAAs) are a family of organic chemicals consisting of a perfluorinated carbon backbone (4-14 carbons in length) and an anionic head group (sulfonate, carboxylate or phosphonate). These compounds have excellent surface-tension reducing properties and hav...
Devopmental toxicity of perfluorooctane Sulfonate (PFOS) is not dependent on expression on peroxisome proliferator activated receptor-alpha (PPAR-alpha)in the mouse (JOURNAL)
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are members of a family of perfluorinated compounds. Both are environmentally persistent and found in the serum of wildlife and humans. PFOS and PFOA are developmentally toxic in laboratory rodents. Exposure to t...
PPARα, PPARβ, and PPARγ expression in prenatal and postnatal mouse tissues and an evaluation of the effects of perfluorooctanoic acid (PFOA) on peroxisome proliferator-activated receptor (PPAR) expression. (PRESENTATION)
PFOA is developmentally toxic, reducing in utero and neonatal survival, and altering development and growth in mice. PFOA activates PPARα and studies in PPARα knockout mice showed that PPARα signaling is required to produce these effects. This study examines the expression of PPA...
Perfluoroctane sulfonate-induced changes in fetal rat liver gene expression (JOURNAL)
In utero exposure of rats to perfluorooctane sulfonate (PFOS, C8F17SO3), a widely disseminated product of the surfactant and coating industries, is associated with residual hepatoxic complications in the surviving offspring. This hepatocellular hypertrophy resembles that observe...
Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanic Acid (PFOA) Exposure in CD-1 Mice: Low Doses Induce Elevated Serum, Leptin, Insulin, and Overweight in Mid-Life. (JOURNAL)
The synthetic surfactant, perfluorooctanoic acid (PFOA) is a proven developmental toxicant in mice, causing prenatal pregnancy loss, increased neonatal mortality, delayed eye opening, and abnormal mammary gland growth in animals exposed during fetal life. PFOA is found in the ser...
The United South and Eastern Tribe (USET) Proper Functioning Condition (PFC) and Tribal Focused Environmental Risk and Sustainability Tool (Tribal-FERST) Train the Trainers Workshop.October 6-9, 2014, in Nashville, Tennessee: PFC Assessment for Management and Monitoring (PUBLISHED REPORT)
The maintenance of wildlife and aquatic habitat is dependent on the development of a riparian area management strategy, which considers and adapts to certain basic ecological and economic relationships. These relationships are functions of riparian and terrestrial ecosystems, gro...
Treatment of Perfluorinated Alkyl Substances in Wash Water Using Granular Activated Carbon and Mixed-Media (PUBLISHED REPORT)
Report
Per- and Polyfluoroalkyl Substances (PFAS): Sampling Studies and Methods Development for Water and Other Environmental Media (COMMUNICATION PRODUCT)
Per- and polyfluoroalkyl substances (PFAS) are a large group of manufactured compounds used in a variety of industries, such as aerospace, automotive, textiles, and electronics, and are used in some food packaging and firefighting materials. For example, they may be used to make ...
PFOA and PFOS: Treatment and Analytics (PRESENTATION)
PFOA and PFOS are not regulated by the USEPA. However, in 2016, USEPA established a Lifetime Drinking Water Health Advisory limit of 70 ng/L for the combined concentration of PFOA and PFOS. This presentation will cover the available technologies that can treat for PFOA and PFOS...
Novel Polyfluorinated Compounds Identified Using High Resolution Mass Spectrometry Downstream of Manufacturing Facilities near Decatur, Alabama (JOURNAL)
Concern over persistence, bioaccumulation, and toxicity has led to international regulation and phase-outs of certain perfluorinated compounds and little is known about their replacement products. High resolution mass spectrometry was used to investigate the occurrence and identi...
Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina (JOURNAL)
Long-chain per- and polyfluoroalkyl substances (PFASs) are being replaced by short-chain PFASs and fluorinated alternatives. For ten legacy PFASs and seven recently discovered perfluoroalkyl ether carboxylic acids (PFECAs), we report (1) their occurrence in the Cape Fear River (C...
U.S. Domestic Cats as Sentinels for Perfluoroalkyl Substances: Possible Linkages with Housing, Obesity and Disease (JOURNAL)
Perfluoroalkyl substances (PFAS), such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) , are persistent, globally distributed, anthropogenic compounds. The primary source(s) for human exposure are not well understood although within home exposure is likely i...
PFOS and PFOS: Analytics (PRESENTATION)
This presentation describes the drivers for development of Method 537, the extraction and analytical procedure, performance data, holding time data as well as detection limits.
Suppression of antigen-specific antibody responses in mice exposed to perfluorooctanoic acid: Role of PPARalpha and T- and B-cell targeting (JOURNAL)
T-cell-dependent antibody responses (TDAR) are suppressed in female C57BL/6N mice exposed to ≥3.75 mg/kg of perfluorooctanoic acid (PFOA) for 15 days. To determine if suppression of humoral immunity by PFOA is peroxisome proliferator activated receptor alpha (PPARa)-dependent and...
Environmental exposures and health impacts of PFAS (PRESENTATION)
Environmental exposures and health impacts of PFAS
Serum concentrations of perfluorinated compounds (PFC) among selected populations of children and Adults in California (JOURNAL)
Perfluorinated compounds (PFCs) have been widely used in industrial applications and consumer products. Their persistent nature and potential health impacts are of concern. Given the high cost of collecting serum samples, this study is to understand whether we can quantify PFC se...
Tribal Ecosystem Research Program (TERP) Workshop: Proper Functioning Condition (PFC) Assessment for Management and Monitoring (PUBLISHED REPORT)
USEPA is developing alternative approaches to quantify improvements to impaired waterbodies (USEPA 303(d)/TMDL Draft Guidance). Tribal environmental programs are leading the way in the paradigm shift towards sustainability of natural resources. Resources such as wildlife, aquatic...
Perfluorinated Compounds in Fish from U.S. Urban Rivers and the Great Lakes (JOURNAL)
Perfluorinated compounds (PFCs) have recently received scientific and regulatory attention due to their broad environmental distribution, persistence, bioaccumulative potential, and toxicity. Some studies suggest that the consumption of fish from contaminated waters may be a maj...
Toxicokinetics of perfluorooctanoate (PFOA) in rainbow trout(Oncorhynchus mykiss) (JOURNAL)
Perfluoroalkyl acids (PFAAs) are widely used as stain resistant coatings for cloth, paper, and leather, and as surfactants, fire-fighting foams, and photographic developers. Individual PFAAs have been shown to accumulate in fish and wildlife; however, the extent of this accumulat...
An Evaluation of Gestational Exposure to Perfluorooctanoic Acid (PFOA): Effects on Body Composition and Physiological Factors (PRESENTATION)
Exposure to environmental pollutants can be a factor for induction of metabolic disorders. This study examined if exposure to PFOA during development could alter body composition and other physiological outcomes. Study 1: Pregnant CD-1 mice were gavaged with PFOA at 0,0.001,0.01,...
Exposure and effects of perfluoroalkyl substances in tree swallows nesting in Minnesota and Wisconsin, USA (JOURNAL)
The exposure and effects of perfluoroalkyl substances (PFASs) were studied at eight locations in Minnesota and Wisconsin between 2007 and 2011 using tree swallows (Tachycineta bicolor) as sentinel species. These eight sites covered a range of possible exposure pathways and ecolog...
Polyfluorinated substances in abiotic standard reference materials (JOURNAL)
The National Institute of Standards and Technology (NIST) has a wide range of Standard Reference Materials (SRMs) which have values assigned for legacy organic pollutants and toxic elements. Existing SRMs serve as homogenous materials that can be used for method development, meth...
Uptake of perfluoroalkyl acids into edible crops via land applied biosolids: Field and greenhouse studies (JOURNAL)
The presence of perfluoroalkyl acids (PFAAs) in biosolids destined for use in agriculture has raised concerns about their potential to enter the terrestrial food chain via bioaccumulation in edible plants. Uptake of PFAAs by greenhouse lettuce ( Lactuca sativa) and tomato (Lycope...