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Records 1 to 25 of 113 Journals about 'developmental neurotoxicity OR neurodevelopment OR DNT NOT dinitrotoluene'

A QUALITATIVE RETROSPECTIVE ANALYSIS OF POSITIVE CONTROL DATA IN DEVELOPMENTAL NEUROTOXICITY STUDIES.
(JOURNAL) [Published : Mar 15, 2004]
A manuscript reviews positive control data submitted by registrants in support of Developmental Neurotoxicity (DNT) guideline studies. Adequate positive control data are needed to evaluate laboratory proficiency in detecting changes in the structure and function of the developin...
Conference Report: Advancing the Science of Developmental Neurotoxicity (DNT) Testing for Better Safety Evaluation
(JOURNAL) [Published : Sep 01, 2012]
1. Introduction The 3rd International Conference on Alternatives for Developmental Neurotoxicity Testing (DNT3), organized by the European Centre for the Validation of Alternative Methods (ECVAM), the Joint Research Centre of the European Commission, was held from May 10 -13, 20...
International STakeholder NETwork (ISTNET): Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes
(JOURNAL) [Published : Feb 01, 2015]
A major problem in developmental neurotoxicity (DNT) risk assessment is the lack of toxicological hazard information for most compounds. Therefore, new approaches are being considered to provide adequate experimental data that allow regulatory decisions. This process requires a m...
International regulatory and scientific effort for improved developmental neurotoxicity testing
(JOURNAL) [Published : Nov 23, 2018]
The Organisation for Economic Co-Operation and Development (OECD) coordinates international efforts to enhance developmental neurotoxicity (DNT) testing. In most regulatory sectors, including the ones dealing with pesticides and industrial chemicals registration, historical use o...
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use
(JOURNAL) [Published : Feb 01, 2017]
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard posed by industrial and environmental chemicals. New testing approaches will most likely be based on batteries of alternative and complementary (non-animal) tests. As DNT is assumed to resul...
Testing for developmental neurotoxicity using a battery of in vitro assays for key cellular events in neurodevelopment
(JOURNAL) [Published : Sep 01, 2018]
Medium- to high-throughput in vitro assays that recapitulate the critical processes of nervous system development have been proposed as a means to facilitate rapid testing and identification of chemicals which may affect brain development. In vivo neurodevelopment is a complex pr...
UNDERTAKING POSITIVE CONTROL STUDIES AS PART OF DEVELOPMENTAL NEUROTOXICITY TESTING: A REPORT FROM THE ILSI RESEARCH FOUNDATION/RISK SCIENCE INSTITUTE EXPERT WORKING GROUP ON NEURODEVELOPMENTAL ENDPOINTS
(JOURNAL) [Published : Jul 01, 2008]
Developmental neurotoxicity testing involves functional and neurohistological assessments in offspring during and following maternal and/or neonatal exposure. Data from positive control studies are an integral component in developmental neurotoxicity risk assessments. Positive ...
BROMATE: A CONCERN FOR DEVELOPMENTAL NEUROTOXICITY?
(JOURNAL) [Published : Mar 31, 2006]
In February of 2005 a workshop was held to evaluate the state-of-the-science of bromate toxicity. The workshop was sponsored by the American Water Works Association - Research Foundation, the Southern Nevada Water Authority, Fairfax Water Authority, and Miami University. This m...
Developmental Neurotoxicity Testing: A Path Forward
(JOURNAL) [Published : Sep 01, 2012]
Great progress has been made over the past 40 years in understanding the hazards of exposure to a small number of developmental neurotoxicants. Lead, PCBs, and methylmercury are all good examples of science-based approaches to characterizing the hazard to the developing nervous s...
The Developmental Neurotoxicity Guideline Study: Issues with Methodology, Evaluation and Regulation
(JOURNAL) [Published : Sep 01, 2012]
Recently social concerns are increasing for the effects of environmental factors on children's health, especially on their nervous system. The U.S. Environmental Protection Agency (EPA) and the Organization for Economic Co-operation and Development (GECD) have published testing ...
Potential Frameworks to Support Evaluation of Mechanistic Data for Developmental Neurotoxicity Outcomes: A Symposium Report
(JOURNAL) [Published : Feb 14, 2020]
Risk assessors have been charged with applying systematic review principles to epidemiological, toxicological, and mechanistic data sets. Potential uses for mechanistic data in risk assessment include providing biological plausibility, informing susceptibility, informing the huma...
Toward a Better Testing Paradigm for Developmental Neurotoxicity: OECD Efforts and Regulatory Considerations
(JOURNAL) [Published : Jan 23, 2021]
Characterization of potential chemical-induced developmental neurotoxicity (DNT) hazard is considered for risk assessment purposes by many regulatory sectors. However, due to test complexity, difficulty in interpreting results and need of substantial resources, the use of the in ...
Current Practices and Future Trends in Neuropathology Assessment for Developmental Neurotoxicity Testing
(JOURNAL) [Published : Mar 09, 2011]
The continuing education course on "Developmental Neurotoxicity Testing" (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and non-invasive imaging, and facilitate a discussion among experienced neu...
Neural Progenitor Cells as Models for High-Throughput Screens of Developmental Neurotoxicity: State of the Science
(JOURNAL) [Published : Jan 10, 2010]
In vitro, high-throughput approaches have been widely recommended as an approach to screen chemicals for the potential to cause developmental neurotoxicity and prioritize them for additional testing. The choice of cellular models for such an approach will have important ramificat...
Retrospective performance assessment of the draft test guideline 426 on developmental neurotoxicity.
(JOURNAL) [Published : Jan 01, 2009]
This document was created by an international panel under the auspices of the International Programme on Chemical Safety of the World Health Programme. The purpose and intent of this retrospective performance assessment document is to review the history of the developmen...
Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework
(JOURNAL) [Published : Nov 01, 2017]
Adequate levels of thyroid hormones (TH) are needed for proper brain development, deficiencies may lead to adverse neurological outcomes in humans and animal models. Environmental chemicals have been linked to TH disruption, yet the relationship between developmental exposures an...
Developmental Neurotoxicity of Engineered Nanomaterials: Identifying Research Needs to Support Human Health Risk Assessment
(JOURNAL) [Published : May 24, 2013]
To inform efforts to plan and implement research that would support future efforts to assess potential risks related to developmental neurotoxicity from ENM exposures
In Vitro Assessment of Developmental Neurotoxicity: Use of Microelectrode Arrays to Measure Functional Changes in Neuronal Network Ontogeny*
(JOURNAL) [Published : Jan 20, 2011]
Because the Developmental Neurotoxicity Testing Guidelines require large numbers of animals and is expensive, development of in vitro approaches to screen chemicals for potential developmental neurotoxicity is a high priority. Many proposed approaches for screening are biochemica...
Thyroid disrupting chemicals and developmental neurotoxicity – New tools and approaches to evaluate hormone action
(JOURNAL) [Published : Dec 01, 2020]
It is well documented that thyroid hormone (TH) action is critical for normal brain development and is mediated by both nuclear and extranuclear pathways. Given this dependence, the impact of environmental endocrine disrupting chemicals that interfere with thyroid signaling is a ...
Developmental Toxicology Evaluations -- Issues With Including Neurotoxicology And Immunotoxicology Assessments In Reproductive Toxicology Studies
(JOURNAL) [Published : Aug 24, 2005]
Developmental and reproductive toxixology (DART) has routinely been a part of safety assessment. Attention is now focused on the effects of chemicals on the developing nervous and immune systems. This focus on developmental neurotoxicology (DNT) and developmental immunotoxicolo...
Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays
(JOURNAL) [Published : Feb 28, 2019]
Thousands of chemicals to which humans are potentially exposed have not been evaluated for developmental neurotoxicity (DNT) potential, driving efforts to develop a battery of in vitro screening approaches for DNT hazard. Here, 136 unique chemicals were evaluated for potential DN...
Media formulation influences chemical effects on neuronal growth and morphology
(JOURNAL) [Published : Jun 01, 2015]
Abstract Screening for developmental neurotoxicity (DNT) using in vitro, cell-based test systems has been proposed as an efficient and cost-effective alternative to performing in vivo DNT studies. One of the pri...
Recommendations for Developing Alternative Test Methods for Screening and Prioritization of Chemicals for Developmental Neurotoxicity
(JOURNAL) [Published : Jan 11, 2011]
Developmental neurotoxicity testing (DNT) is perceived by many stakeholders to be an area in critical need of alternative methods to current animal testing protocols and gUidelines. An immediate goal is to develop test methods that are capable of screening large numbers of chemic...
Defining toxicological tipping points in neuronal network development
(JOURNAL) [Published : Sep 01, 2018]
Measuring electrical activity of neural networks by microelectrode array (MEA) has recently shown promise for screening level assessments of chemical toxicity on network development and function. Important aspects of interneuronal communication can be quantified from a single MEA...
Developmental Neurotoxicology: History and Outline of Developmental Neurotoxicity Study Guidelines.
(JOURNAL) [Published : Jun 29, 2015]
The present work provides a brief review of basic concepts in developmental neurotoxicology, as well as current representative testing guidelines for evaluating developmental neurotoxicity (DNT) of xenobiotics. Historically, DNT was initially recognized as a “functional” teratoge...