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  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 1 to 25 of 7344

2024
Examples of How Data from in vitro Developmental Neurotoxicity Assays Are Being Used to Make Decisions About Chemicals
(PRESENTATION) [Presented : Sep 02, 2021]
Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data
(JOURNAL) [Published : Jan 30, 2024]
Background:  Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...
Hepatic Transcriptome Comparative Analysis Reveals Similar Pathways and Targets Altered by Legacy and Alternative Per- and Polyfluoroalkyl Substances
(PRESENTATION) [Presented : Apr 19, 2024]
This is a talk I will give as part of the Toxics Webinar | Issue Cover Authors of 2023. I will only discuss published work that has been cleared and published in Toxics last year.
A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics)
(JOURNAL) [Published : Apr 05, 2024]
Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...
Summary of Research on Airborne Tire Wear including 6PPD/6PPD-quinone- Tyre Emissions and Sustainability Conference: April 2024
(PRESENTATION) [Presented : Apr 25, 2024]
With the declining tailpipe emissions from the US and worldwide motor vehicle fleet, impacts of tire and brake wear are an increasingly important area of interest.  Recent research has shown the compound 6PPD used in tires as an anti-degradation chemical reacts with ozone to...
SOT_Developmental toxicity across a suite of structurally diverse per- and polyfluoroalkyl substances (PFAS) in mummichog (Atlantic killifish)
(PRESENTATION) [Presented : Mar 14, 2024]
Per- and polyfluoroalkyl substances (PFAS) are increasingly at the forefront of environmental concern. Despite their frequent detection in environmental media, the highly persistent nature of many PFAS, and growing evidence demonstrating adverse health effects in a variety of spe...
New approach methods for developmental neurotoxicity: a per- and polyfluoroalkyl substances (PFAS) case study
(PRESENTATION) [Presented : Mar 21, 2024]
Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research
By-degree Health and Economic Impacts of Lyme Disease, Eastern and Midwestern United States
(JOURNAL) [Published : Mar 13, 2024]
Journal article submitted to EcoHealth - (Abstract) - Lyme disease (LD) is the most common vector-borne disease in the United States (U.S.). This paper assesses how climate change may influence LD incidence in the eastern and upper midwestern U.S., and the associated economic bur...
Methods to Identify Hazards in Produced Water
(PRESENTATION) [Presented : Apr 05, 2024]
This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.
Trimethylbenzenes - Encyclopedia of Toxicology chapter
(BOOK CHAPTER) [Published : Apr 14, 2014]
Trimethylbenzene (TMB; CAS 25551-13-7) is a commercially available mixture of three individual isomers: 1,2,4-, 1,2,3-, and 1,3,5-TMB. TMB isomers are produced during petroleum refining. TMB exposure in humans occurs primarily through inhalation, although ingestion of TMB isomers...
In vitro mobilization of polychlorinated biphenyls and pesticides sorbed to ingested soils and house dusts
(PRESENTATION) [Presented : Mar 14, 2024]
Background and PurposeSoil and dust are effective sorbents for many organic chemicals and are known to concentrate lipophilic, less volatile, environmental pollutants. For children’s risk assessment, this is important, primarily because children consume relatively large qua...
Career Day
(PRESENTATION) [Presented : Apr 12, 2024]
Career Day at East Cary Magnet Middle School
Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (Syngenta SOT 24)
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose:   Limitations to the in vivo developmental neurotoxicity (DNT) test includes high variability, low reproducibility, and unknown human relevance. Moreover, neuropathological assessments in the DNT guideline are challenging due to methodology, lack of mecha...
Arsenic, cadmium, lead, antimony bioaccessibility and relative bioavailability in legacy gold mining waste
(JOURNAL) [To be published : May 05, 2024]
Bioaccessibility and relative bioavailability of As, Cd, Pb and Sb was investigated in 30 legacy gold mining wastes (calcine sands, grey battery sands, tailings) from Victorian goldfields (Australia). Pseudo-total As concentration in 29 samples was 1.45–148-fold higher than...
US experience for NAM Implementation for DNT
(PRESENTATION) [Presented : Apr 10, 2024]
Presentation to the 5th International Conference on Developmental Neurotoxicity Testing (DNT5) April 2024
Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways using Omics Approaches
(PRESENTATION) [Presented : Apr 10, 2024]
Development of in vitro new approach methodologies (NAMs) has been driven by the need for developmental neurotoxicity (DNT) hazard data on thousands of chemicals. The network formation assay (NFA) characterizes DNT hazard based on changes in network formation but provides no mech...
Identification of training set chemicals to demonstrate the transferability of the developmental neurotoxicity in vitro battery
(PRESENTATION) [Presented : Apr 10, 2024]
The developmental neurotoxicity (DNT) in vitro battery (IVB) is a group of new approach methods for evaluation of potential compound effects on fundamental neurodevelopmental processes. These assays were developed to enhance efficiency of chemical screening and prioritization rel...
Sulfonamide PFAS cause developmental abnormalities in mummichogs (Fundulus heteroclitus)
(PRESENTATION) [Presented : Apr 12, 2024]
Per- and polyfluoroalkyl substances (PFAS) are long-lasting environmental contaminants with known adverse impacts on fish and other taxa. However, understanding of their impacts on coastal environments, including the effect of chemical structure on toxicity in estuarine and marin...
Computational Systems Models for Neurovascular Development
(PRESENTATION) [Presented : Apr 10, 2024]
Computational Systems Models for Neurovascular Development Thomas B. Knudsen, Research Triangle Park, NC   Morphogenesis of the blood-brain barrier (BBB) is a complex process linked to neovascularization of the embryonic neural tube. This selective transport interface forms...
Using early life stage assays to assess impact of a suite of diverse PFAS exposures in the mummichog (Fundulus heteroclitus)
(PRESENTATION) [Presented : Apr 12, 2024]
Per- and polyfluoroalkyl substances (PFAS) are widely used, long-lasting environmental contaminants linked to adverse effects in fish and other species. There are thousands of unique PFAS that are likely to impact organisms in different ways and through different mechanisms. The ...
Assessing lead exposure in U.S. pregnant women using biological and residential measurements
(JOURNAL) [Published : Sep 21, 2023]
There is strong scientific evidence for multiple pathways of human exposure to lead (Pb) in residential settings, particularly for young children; however, less is known about maternal exposure during pregnancy and children’s exposure during early lifestages. A robust, mult...
EPA Children's Environmental Health Research Centers
(PRESENTATION) [Presented : Mar 20, 2024]
This is a short presentation to the Subcommittee on Chemical Exposures of the President's Task Force on Environmental Health Risks and Safety Risks to Children. The presentation briefly touches on the STAR program history of ORD funding for Children's Centers, and discusses our c...
SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity
(PRESENTATION) [Presented : Mar 14, 2024]
Environmental justice seeks to affirm individual’s rights to a healthy environment within communities that are subjected to a disproportionate burden of environmental hazard. These communities often experience higher levels of chronic stress and reduced quality of life, whi...
Evaluating two analysis methods for the microelectrode array network formation assay
(PRESENTATION) [Presented : Mar 14, 2024]
Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...
New Approach Methodology for Developmental Neurotoxicity: Past, Present and Future
(PRESENTATION) [Presented : Mar 22, 2024]
Topics covered: Brief History of the EPA and Regulatory Statutes; Need for Alternative Approaches for Neurotoxicity and Developmental Neurotoxicity Hazard Assessment; Brief History of NAMs for DNT; Examples of How DNT NAMs are being utilized for decision-making; Informing AOP Dev...