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Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.

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2024

Meta-Analysis of Small for Gestational Age Births and Disinfection Byproduct Exposures
(JOURNAL) [Published : Oct 06, 2020]

Meta-analysis of Small for Gestational Age Births and Aggregate Disinfection By-product Exposures Background: Some epidemiological studies show associations between disinfection byproducts (DBPs) and adverse developmental outcomes. Objectives: We undertook a meta-analysis of epid...

United States house dust Pb concentrations are influenced by soil, paint, and house age: insights from a national survey
(JOURNAL) [Published : Jul 30, 2024]

Background Lead (Pb) in house dust contributes significantly to blood lead levels (BLLs) in children which may result in dire health consequences. Assessment of house dust Pb in the United States, relationships with Pb in soil and paint, and residential factors influencing Pb con...

Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery
(EXTRAMURAL DOCUMENT) [Published : Nov 03, 2023]

Developmental neurotoxic chemicals are a diverse set of substances that have the potential to interfere with the normal development of the nervous system, which, if perturbed without compensation, may lead to adverse effects on nervous system structures and/or functions. The purp...

Parvalbumin as a Target for Thyroid Hormone Mediated Developmental Neurotoxicity
(PRESENTATION) [Presented : Jun 24, 2024]

Thyroid hormones (TH) are critical for neurodevelopment. Parvalbumin (Pvalb), a calcium binding protein in a large population of cortical inhibitory interneurons has been shown in mutant mouse models to be sensitive to TH disruption. Pvalb-expressing interneurons are critical to ...

Maintaining Balance: Examining Deiodination of Thyroid Hormones in the Developing Brain
(PRESENTATION) [Presented : Jun 25, 2024]

Thyroid hormones (TH) regulate development, growth, and metabolism. Deiodinases (DIOs) are metabolizing enzymes that activate (Dio2) and deactivate (Dio3) THs, exerting the precise local control over TH action that is critical for brain development. In vitro assays have identifie...

Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS)
(JOURNAL) [Published : Jul 25, 2024]

Background: Per- and polyfluoroalkyl Substances (PFAS) are synthetic chemicals widely detected in humans and the environment. Exposure to perfluorooctanesulfonic acid (PFOS) or perfluorohexanesulfonic acid (PFHxS) was previously shown to cause dark-phase hyperactivity in lar...

Changes in CpG Methylation of the Vitellogenin 1 Promoter in Adult Male Zebrafish after Exposure to 17α-Ethynylestradiol
(JOURNAL) [Published : Jul 01, 2024]

Numerous pharmaceutical and industrial chemicals are classified as endocrine-disrupting chemicals (EDCs) that interfere with hormonal homeostasis, leading to developmental disorders and other pathologies. The synthetic estrogen 17α-ethynylestradiol (EE2) is used in oral con...

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS)
(JOURNAL) [Published : Jul 10, 2024]

Per- and polyfluoroalkyl substances (PFAS) are found in many consumer and industrial products. While some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are developmentally toxic in mammals, the vast majority of PFAS have not been evaluated f...

Maternal and neonatal effects of maternal oral exposure to perfluoro-2-methoxyacetic acid (PFMOAA) during pregnancy and early lactation in the Sprague-Dawley rat
(JOURNAL) [Published : Jan 16, 2024]

PFMOAA was identified by EPA chemists to be the highest concentration PFAS in eastern NC drinking water samples, however only a single published study exists for this compound.  Further, it is a very short chain PFAS and toxicological questions exist as to the ability for sh...

Evaluating potential developmental toxicity of perfluoroalkyl and polyfluoroalkyl substances in Xenopus laevis embryos and larvae
(JOURNAL) [Published : Jun 21, 2024]

As part of the US Environmental Protection Agency's perfluoroalkyl and polyfluoroalkyl substances (PFAS) Action Plan, the agency is committed to increasing our understanding of the potential ecological effects of PFAS. The objective of these studies was to examine the development...

Human Relevance of Rodent Liver Tumors: Key Insights from a Toxicology Forum Workshop on Nongenotoxic Modes of Action
(JOURNAL) [Published : Feb 01, 2018]

The Toxicology Forum sponsored a workshop in October 2016, on the human relevance of rodent liver tumors occurring via nongenotoxic modes of action (MOAs). The workshop focused on two nuclear receptor-mediated MOAs (Constitutive Androstane Receptor (CAR) and Peroxisome Proliferat...

Identification of the herbicide, Oxyfluorfen, as an endocrine disrupting chemical using in vitro targeted screens and the Tier 1 Male Pubertal assay.
(PRESENTATION) [Presented : Mar 12, 2024]

Identification of the herbicide, Oxyfluorfen, as an endocrine disrupting chemical using in vitro targeted screens and the Tier 1 Male Pubertal assay.  Murr, AS1, A. Buckalew1, Bailey, J.3, Ford, J.2 and Stoker, TE1. 1Neurological and Endocrine Toxicology Branch, PHITD, CPHE...

Early gestational ozone exposure impairs lung vascular and alveolar development in peri-adolescent female rats: Potential linkage to later life lung disease.
(PRESENTATION) [Presented : May 23, 2024]

RATIONALE Air pollution exposure in pregnancy may affect fetal growth, and fetal growth restriction (FGR) is associated with lung impairment that can persist into adulthood. Associated diseases include asthma, pulmonary hypertension (PH), and chronic obstructive pulmo&...

3.07 - Environment-Induced Epigenetic Modifications as Therapeutic Targets for Prevention and Treatment
(BOOK CHAPTER) [Published : Jan 01, 2024]

Epigenetics holds great promise within the clinical and health fields both for its ability to impact health outcomes and for its ability to be a record of the exposures an individual receives. While the role of epigenetics in environmental health is still being established, it is...

Accelerated aging and altered sub-clinical response to ozone exposure in young, healthy adults
(JOURNAL) [Published : May 07, 2024]

Ozone exposure induces a myriad of adverse cardiopulmonary outcomes in humans. Although advanced age and chronic disease are factors that may exacerbate a person's negative response to ozone exposure, there are no molecular biomarkers of susceptibility. Here, we examine whether e...

Using Targeted Fetal Rat Testis Genomic and Endocrine Alterations to Predict the Effects of a Phthalate Mixture on the Male Reproductive Tract.
(JOURNAL) [Published : Jun 18, 2024]

Administration of phthalates in utero disrupts gene expression and hormone levels in the fetal rat testis, which are key events in an Adverse Outcome Pathway (AOP) for the Phthalate Syndrome. These measures can be used to predict the postnatal adverse effects of phthalate esters ...

Evaluation of the diphenyl herbicide, Oxyfluorfen, for effects on thyroid hormones in the juvenile rat.
(JOURNAL) [Published : Dec 27, 2023]

Recently, oxyfluorfen, a pre- and post-emergent diphenyl ether herbicide, was identified in our laboratory as an inhibitor of iodide uptake by the sodium iodide symporter (NIS), the first key step in the synthesis of thyroid hormones (THs). This inhibition was observed in vi...

Pervasive environmental chemicals impair oligodendrocyte development
(JOURNAL) [Published : May 01, 2024]

Exposure to environmental chemicals can impair neurodevelopment, and oligodendrocytes may be particularly vulnerable, as their development extends from gestation into adulthood. However, few environmental chemicals have been assessed for potential risks to oligodendrocytes. Here,...

Occupational Neurotoxicity of Organic Solvents
(BOOK CHAPTER) [Published : Jul 23, 2022]

Organic solvents are a diverse set of chemicals and chemical mixtures that are among the most widely used class of chemicals in industry and commerce. Many solvents are volatile leading to a risk of inhalation exposure. Typically, solvents are also highly lipid soluble and readil...

Effect of Inter-individual Variability on a Phenotypic Endpoint Battery in an In Vitro Co-culture Model of the Human Respiratory Tract after Exposure to Model Reactive Gas Acrolein
(PRESENTATION) [Presented : Mar 20, 2023]

Many untested, ubiquitous inhalable toxicants may drive adverse human health effects. The “Tox21” program seeks to increase chemical testing throughput by integrating in vitro new approach methodologies (NAMs) to address challenges including developing tiered-testing ...

Identification of Anatoxin-a and Relevant Metabolites in Biological Matrices with High Resolution Mass Spectrometry
(PRESENTATION) [Presented : Jun 06, 2024]

Harmful algal blooms (HABs) have become a global concern and necessitate ongoing surveillance to monitor the effects of these blooms and their associated cyanotoxins. One such cyanotoxin, anatoxin-a (ATX), is a potent neurotoxin produced during select HABs. ATX is found frequentl...

Alterations in behavior and proteomics following perinatal agonism of GABA-gated chloride channels in Long Evans rats
(PRESENTATION) [Presented : Jun 23, 2024]

The period of neurodevelopment is vulnerable to various insults, including those produced by environmental compounds. Here we used prototypical neurotoxicants to explore both behavioral and molecular alterations that can occur following chemical exposure during development. Pregn...

Advancing Translational Application and Acceptance of the Human Thyroid Microtissue Assay (ASCCT-ESTIV webinar)
(PRESENTATION) [Presented : Jul 16, 2024]

Invited presentation for the ASCCT-ESTIV webinar - Progress in in vitro Thyroid Disruption Approaches. Abstract: The human thyroid microtissue (hTMT) assay utilizes primary human thyrocytes to reproduce structural and functional features of the thyroid gland to enable testing for...

The Salmon Toxicity Translator
(PRESENTATION) [Presented : Jun 15, 2023]

Toxicity translators are models that use life history and demographic information to interpret effects measured in laboratory toxicity tests into metrics that are applicable to understanding ecological impacts. Translators use variation in life history strategies to improve extra...

Peer Review of Report Modeling the Relationship Between Lead in Drinking Water and Blood Lead Levels in Children
(ASSESSMENT DOCUMENT) [Published : Oct 25, 2017]

EPA is peer reviewing the Agency’s report modeling the relationship between lead in drinking water and blood lead levels in children utilizing the Integrated Exposure Uptake Biokinetic (IEUBK) model. The report being peer reviewed may be used to inform the derivation of a concent...