EPA Science Inventory

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Records with

  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 1 to 25 of 4216

2018
Identification of vascular disruptor compounds by a tiered analysis in zebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
20161106 - Human Pluripotent Stem Cell-Based Assay Predicts Developmental Toxicity Potential of ToxCast Chemicals (ACT meeting) (PRESENTATION)
Worldwide initiatives to screen for toxicity potential among the thousands of chemicals currently in use require inexpensive and high-throughput in vitro models to meet their goals. The devTOX quickPredict platform is an in vitro human pluripotent stem cell-based assay used to as...
A Cellular Game of Telephone: Trans Tissue Reprogramming of Responses to Toxic Stimuli (PRESENTATION)
Exposure to air pollution is a leading cause of cardiopulmonary morbidity and mortality; however, while these effects outside the lung have been associated with aberrant oxidative stress and inflammation, the underlying molecular mechanisms are poorly understood. We hypothesized ...
A Disadvantaged Advantage in Walkability: Findings from Socioeconomic and Geographic Analysis of National Built Environment Data in the United States. (JOURNAL)
Urban form-the structure of the built environment-can influence physical activity, yet little is known about how walkable design differs according to neighborhood sociodemographic composition. We studied how walkable urban form varies by neighborhood sociodemographic composition,...
A Literature Review and Data Mining Project to Identify Associations between Stressors and Health Outcomes for Children (PRESENTATION)
Children are often more vulnerable than adults to the effects of environmental contaminants found in their everyday environments. Their dynamic growth and unique interactions with the built, natural, and social environments may result in a greater susceptibility to chemical and n...
A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. (EXTRAMURAL DOCUMENT)
This collection of 3 AOPs describe varying outcomes of adversity dependent upon species in response to inhibition of thyroperoxidase (TPO) during development. Chemical inhibition of TPO, the molecular-initiating event (MIE), results in decreased thyroid hormone (TH) synthesis, a...
A Review of Stressors from the Built and Natural Environments Impacting American Indian Children’s Health and Well-Being (PRESENTATION)
Exposures to chemical and non-chemical stressors from children’s environments during early development may contribute to differences in their health and well-being outcomes. Children from American Indian tribes may have a disproportionate burden of these stressors from thei...
A mixture of 18 anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat (PRESENTATION)
This product is a regional conference abstract and award application. The abstract primarily serves as the application for the NCSOT PARC Award and secondarily as a poster abstract for the fall meeting of NCSOT at NIEHS.
ACTIVE VS. SEDENTARY LIFESTYLE FROM WEANING TO ADULTHOOD AND SUSCEPTIBILITY TO OZONE IN RATS (JOURNAL)
This is publication for a peer review journal.
Acute Gastroenteritis and Recreational Water: Highest Burden Among Young US Children (JOURNAL)
OBJECT I VES : To provide summary estimates of gastroenteritis risks and illness burden associated with recreational water exposure and determine whether children have higher risks and burden.METHODS: We combined individual participant data from 13 prospective cohorts at marine a...
Acute pulmonary and innate immunity health effects in mice inhaling cookstove emissions (PRESENTATION)
Background: Burning of solid-fuels in rudimentary stoves generates harmful emissions that contribute to poor indoor air quality and have detrimental impacts on human health. Acute health effects include respiratory and eye irritation, cough, acute lower respiratory infection and ...
Adult Hippocampal Neurogenesis is Impaired by Transient and Moderate Developmental Thyroid Hormone Disruption (JOURNAL)
Severe thyroid hormone (TH) deprivation during development impairs neurogenesis throughout the brain. The hippocampus also maintains a capacity for neurogenesis throughout life which is reduced in adult-onset hypothyroidism. This study examined hippocampal volume in the neonate a...
Adult Onset-Hypothyroidism: Alterations in Hippocampal Field Potentials in the Denate Gyrus are Largely Associated with Anesthesia-Induced Hypothermia (JOURNAL)
Thyroid hormone (TH) is essential for a number of physiological processes and is particularly critical during nervous system development. The hippocampus is a structure strongly implicated in cognition and is sensitive to developmental hypothyroidism. The impact of TH insuffici...
Adverse Outcome Database (AOPdb) (DATA)
The AOPwiki serves to make expert knowledge of biological mechanism of adverse effects publically available, but also organizes the information for further consumption and processing. What is not yet possible with existing tools is to look across individual AOPs for potential bio...
Age-related differences in pulmonary effects of acute and subchronic episodic ozone exposures in Brown Norway rats (JOURNAL)
Ozone (O3) is known to induce adverse pulmonary and systemic health effects. Importantly, children and older persons are considered at-risk populations for O3-induced dysfunction, yet the mechanisms accounting for the age-related pulmonary responses to O3 are uncertain. In this s...
Analysis of Total Food Intake and Composition of Individual's Diet Based on the U.S. Department of Agriculture's 1994-96, 1998 Continuing Survey of Food Intakes by Individuals (CSFII) (2005, Final Report) (PUBLISHED REPORT)
EPA released the final report, <i>Analysis of Total Food Intake and Composition of Individual’s Diet Based on USDA’s 1994-1996, 98 Continuing Survey of Food Intakes by Individuals (CSFII).</i> The consumption of food by the general population is a significant route of potential ...
Analysis of thyroid hormones in biological samples using stable isotope dilution liquid chromatography-tandem mass spectrometry (PRESENTATION)
This poster presentation will describe analytical chemistry methods for measuring thyroid hormones and related precursors and metabolites in very small tissue or plasma samples. These methods are amenable to measure thyroid hormones in amphibian tadpoles or small mammals used as ...
Assessment of Biochemical and Behavioral Effects of Carbaryl and Methomyl in Brown-Norway Rats from Preweaning to Sensecence (JOURNAL)
Factors impacting life stage-specific sensitivity to chemicals include toxicokinetic and toxicodynamic changes. To evaluate age-related differences in the biochemical and behavioral impacts of two typical N-methyl carbamate pesticides, we systematically compared their dose-respo...
Assessment of the vitro dermal irritation of cerium silver and titanium nanoparticles in a human skin equivalent model (JOURNAL)
AbstractDermal exposure to metals may res·ult in irritant contact dermatitis. This study examined the potential of metal nanoparticles to elicit irritant contact dermatitis in a human skin equivalent model (HSEM) derived from epidermal keratinocytes. These cultured cells form a m...
Association of land use and its change with beach closure in the United States, 2004-2013 (JOURNAL)
Land use and its change have great influences on water quality. However, their impacts on microbial contamination of beach water have been rarely investigated and their relationship with beach closure is still unknown. Here, we analyzed beach closure data obtained from 2004 to 20...
Asthma as a disruption in iron homeostasis (JOURNAL)
Over several decades, asthma has evolved from being recognized as a single disease to include a diverse group of phenotypes with dissimilar natural histories, pathophysiologies, responses to treatment, and distinctive molecular pathways. With the application of Occam’s razor to ...
Athletes’ Selected Micro-Activities on Turf Fields: Utilizing Extant Videography for Quantification of Events During Soccer, American Football, and Field Hockey Play (PRESENTATION)
Concerns have been recently raised about the potential exposures of athletes to chemicals when playing on synthetic turf fields. Previous research has shown that micro-activities (i.e., hand-to mouth and skin-to-surface contacts) are important factors in people’s exposures to che...
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression (JOURNAL)
Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are they modi...
CH 21: Toxic Responses of the Reproductive System (BOOK CHAPTER)
Any evaluation of toxicity to reproduction will have as an important consideration that events may not only be on the adults having impact on their likelihood to have children, but also impact the viability and quality of life of their potential offspring and feasibly even affect...