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  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 1 to 25 of 6467

2021
Update on Endocrine Work at the US EPA (OECD)
(PRESENTATION) [Presented : May 27, 2021]
This talk will give an update on Endocrine-Related AOP Development (ecological) at the US EPA. The goal is in developing adverse outcome pathways (AOPs) to translate new approach methodologies (NAMs) to reproductive effects (Estrogen Receptor, Androgen Receptor, aromatase inhibit...
Implementation of a Systematic Review Framework to Evaluate the Need for Reassessment of Methylmercury
(PRESENTATION) [Presented : Sep 08, 2019]
Multiple health agencies (Health Canada, 2007; UNEP, 2002; US EPA, 2001, 1997; ATSDR, 1999) and the US National Academy of Sciences (NRC, 2000) have established that prenatal oral exposure to methylmercury in humans causes developmental neurotoxicity (DNT). The existing US EPA qu...
Advancing Pb Exposure and Biokinetic Modeling for U.S. EPA Regulatory Decisions and Site Assessments Using Bunker Hill Mining and Metallurgical Complex Superfund Site Data
(PUBLISHED REPORT) [Published : May 05, 2021]
The Integrated Exposure Uptake Biokinetic (IEUBK) Model for Lead in Children was developed by the U.S. EPA to support assessments of health risks from exposures of children to Pb (lead). This report documents the performance evaluation of the IEUBK v2.0 model as it would be typic...
Evaluation of the Mechanistic and Toxicological Evidence on Benzo[a]Pyrene-Induced Male Reproductive Effects Using the Key Characteristics Approach
(PRESENTATION) [Presented : Dec 08, 2019]
The hazard evaluation of potential chemical-induced adverse effects in the male reproductive system involves the analysis and synthesis of epidemiological toxicological and mechanistic evidence. Mechanistic evidence can inform biological plausibility and thus plays an important r...
Use of Medicaid and housing data may help target areas of high asthma prevalence
(JOURNAL) [Published : Mar 01, 2017]
Objective: To determine if there was a significant difference between mold contamination and asthma prevalence in Detroit and non-Detroit Michigan homes, between newer and older homes, and if there is a correlation between mold contamination and measures of Medicaid use for asthm...
Fluorinated Compounds in U.S. Fast Food Packaging
(JOURNAL) [Published : Mar 14, 2017]
Per- and polyfluoroalkyl substances (PFASs) are highly persistent synthetic chemicals, some of which have been associated with cancer, developmental toxicity, immunotoxicity, and other health effects. PFASs in grease-resistant food packaging can leach into food and increase dieta...
Applying the Key Characteristics Approach for Hazard Identification and Risk Assessment of Chemical Induced Cancer and Non-Cancer Effects
(PRESENTATION) [Presented : Dec 08, 2019]
Analysis of mechanistic evidence as part of a human health assessment can inform biological plausibility and human relevance of effects observed in in-vivo and in-vitro experimental models. Since their identification, the Key Characteristics of Carcinogens have served as an appro...
Mode of action and human relevance evaluation of Dibutyl Phthalate (DBP)-induced male reproductive system toxicity-Poster
(PRESENTATION) [Presented : Apr 10, 2019]
In vivo studies using various rat strains have shown that dibutyl phthalate (DBP), a phthalate ester used as a plasticizer, alters normal development of the male reproductive system by disrupting androgen synthesis during the masculinization programming window. However, studies u...
The eight key characteristics of male reproductive toxicants: an approach for screening and evaluating mechanistic evidence.-Poster
(PRESENTATION) [Presented : Mar 10, 2019]
Systematic review approaches in human health assessment includes the integration of evidence from experimental, epidemiological, and mechanistic studies. The process of screening and evaluating evidence can be challenging due to the diversity of research models, methods, outcomes...
Key characteristics of male reproductive toxicants: an approach for screening and sorting mechanistic evidence Abstract
(PRESENTATION) [Presented : Dec 11, 2018]
Since the introduction of ten key characteristics of carcinogens as a basis for organizing mechanistic data on carcinogenesis, the National Academy of Sciences has recommended that key characteristics approaches also be developed for noncancer hazards. The aim of this project was...
Key characteristics of male reproductive toxicants: an approach for screening and sorting mechanistic evidence -Poster
(PRESENTATION) [Presented : Dec 11, 2018]
Since the introduction of ten key characteristics of carcinogens as a basis for organizing mechanistic data on carcinogenesis, the National Academy of Sciences has recommended that key characteristics approaches also be developed for noncancer hazards. The aim of this project was...
Ozone exposure during early pregnancy and preterm birth: a systematic review and meta-analysis
(JOURNAL) [Published : May 12, 2021]
Exposure to ozone has been linked to reproductive outcomes, including preterm birth. In this systematic review, we summarize published epidemiologic cohort and case-control studies examining ozone exposures (estimated on a continuous scale) in early pregnancy (1st and 2nd trimest...
Neuropsychological Tests Used to Assess Methylmercury Developmental Neurotoxicity
(PRESENTATION) [Presented : Sep 08, 2019]
Methylmercury is a well-known developmental neurotoxicant. In an effort to evaluate studies published since the release of the U.S. EPA IRIS Methylmercury Assessment in 2001, which was based on an assessment by the National Academies of Science (NAS) in 2000, a literature search ...
Characterization of developmental toxicity and Adverse Outcome Pathways for emerging PFAS - individual compounds and mixtures
(PRESENTATION) [Presented : Jan 13, 2021]
There is growing global concern about the health effects of per- and polyfluorinated alkyl substances (PFAS) due to widespread exposure from a variety of sources. Human biomonitoring data from multiple countries have indicated that virtually all humans carry residues of multiple ...
Health Canada Course: Effects of in utero, pubertal and adult exposures to toxicants on the male and female reproductive system
(PRESENTATION) [Presented : Feb 17, 2021]
Normal and Abnormal Development of the Reproductive System: Pubertal (M+F) and Adult Exposures (M) And Normal and Abnormal Postnatal Development of the Male and Female Reproductive System following exposure in utero and early postnatal exposures
UST Finder: The National Underground Storage Tanks and Release Web Map Region 6,7 & 8 Workshop
(PRESENTATION) [Presented : May 18, 2021]
The U. S. Environmental Protection Agency (EPA), along with the Association of State and Territorial Solid Waste Management Officials, developed UST Finder, a flexible web map application containing a comprehensive, state sourced national map of underground storage tank (UST) and...
Chapter 2.7: β-Methylamino-L-alanine (BMAA)
(BOOK CHAPTER) [Published : Feb 28, 2021]
The chapter includes discussions of the formation and history of the BMAA-human neurodegenerative disease hypothesis on both Guam and the U.S.; the postulated human exposures from foods and environmental exposures; evidence for the relationship of BMAA and human disease; the toxi...
Evidence Consistency via a Study Quality Lens in Systematic Reviews: a case-study of formaldehyde exposure and respiratory associations
(PRESENTATION) [Presented : Aug 28, 2019]
In this poster, consistency across study results is examined via forest plots stratifying by population, exposure (low vs high), overall study confidence, and specific domain ratings. Although the effect estimates vary considerably, when the effect estimates are stratified by exp...
Underground Storage Tanks and Implications for Private Domestic Wells
(PRESENTATION) [Presented : May 25, 2021]
This presentation will be givent to the Private Well Conference. It covers national perspectives on our underground and leaking underground storage tank universe, the age of this univesre, and the potential impact of extreme weather on UST infrastructure. Also discussed are metho...
Biological Activity in US Food Processing Plant Effluent
(PRESENTATION) [Presented : May 06, 2021]
Extended Abstract submission for platform presentation at SETAC Europe Virtual Annual Meeting: ABSTRACT: Complex mixtures of anthropogenically-derived chemicals in freshwater environments have long been established. We previously evaluated agricultural, municipal, and industrial ...
Characterization of developmental toxicity and Adverse Outcome Pathways (AOPs) for emerging PFAS – individual compounds and mixtures
(PRESENTATION) [Presented : Apr 26, 2021]
No associated abstract, this is an invited presentation for the Interagency Risk Assessment Consortium (IRAC)
Developmental toxicity of emerging PFAS in NC in the Sprague-Dawley rat
(PRESENTATION) [Presented : Apr 05, 2021]
No associated abstract - this is an invited presentation to the North Carolina Secretaries' Science Advisory Board
Public and Private Tapwater: Comparative Analysis of Contaminant Exposure and Potential Risk, Cape Cod, MA, USA
(JOURNAL) [To be published : Jul 01, 2021]
Humans are primary drivers of environmental contamination worldwide, including in drinking-water resources. In the United States (US), federal and state agencies regulate and monitor public-supply drinking water while private-supply monitoring is rare; the current lack of directl...
Patterns and predictions of drinking water nitrate violations across the conterminous United States
(JOURNAL) [Published : Jun 01, 2020]
Excess nitrate in drinking water is a human health concern, especially for young children. When a public drinking water system exceeds the 10 mg nitrate-N/L maximum contaminant level (MCL), that system is in violation of the U.S. Environmental Protection Agency’s (EPA) Nati...
Update on the ToxCast Pipeline and Invitrodb
(PRESENTATION) [Presented : Mar 26, 2021]
The US Environmental Protection Agency (EPA) ToxCast data pipeline (tcpl) has been applied to hundreds of assay endpoints covering diverse biological endpoints, including approximately 1800 genes and bioactivities including mitochondrial toxicity, nuclear receptor activation, imm...