EPA Science Inventory

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Records with

  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 1 to 25 of 5838

2018
Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
2013 NIEHS/EPA Children's Centers Annual Meeting: Protecting Children's Health for a Lifetime (EPA PUBLISHED PROCEEDINGS)
This report includes proceedings from the 2013 NIEHS/EPA Children's Centers Annual Meeting, held in Washington D.C. in October, 2013. Summaries of presentations, speaker biosketches, poster abstracts, and a meeting participant list are all included.
2015 NIEHS/EPA Children's Centers Annual Meeting Report (EPA PUBLISHED PROCEEDINGS)
The report includes proceedings from the 2015 NIEHS/EPA Children's Centers Annual Meeting. The proceedings include presentation summaries, speaker biosketches, poster abstracts, and a list of meeting participants.
A Cell Model to Evaluate Chemical Effects on Adult Human Cardiac Progenitor Cell Differentiation and Function (PRESENTATION)
Adult cardiac stem cells (CSC) and progenitor cells (CPC) represent a population of cells in the heart critical for its regeneration and function over a lifetime. The impact of chemicals on adult human CSC/CPC differentiation and function is unknown. Research was conducted to dev...
A Cellular Game of Telephone: Trans Tissue Reprogramming of Responses to Toxic Stimuli (PRESENTATION)
Exposure to air pollution is a leading cause of cardiopulmonary morbidity and mortality; however, while these effects outside the lung have been associated with aberrant oxidative stress and inflammation, the underlying molecular mechanisms are poorly understood. We hypothesized ...
A Disadvantaged Advantage in Walkability: Findings from Socioeconomic and Geographic Analysis of National Built Environment Data in the United States. (JOURNAL)
Urban form-the structure of the built environment-can influence physical activity, yet little is known about how walkable design differs according to neighborhood sociodemographic composition. We studied how walkable urban form varies by neighborhood sociodemographic composition,...
A Genomic Response to Trace Fear Conditioning in the Amygdala of Female Rats After Developmental Exposure to Manganese (PRESENTATION)
Increases in brain-derived neurotrophic factor (Bdnf), Ca2+/calmodulin-dependent protein kinase II alpha (Camk2a), and cyclic adenosine monophosphate (cAMP) response element binding (Creb1) gene expression have been associated with learning in a variety of different rodent studie...
A Literature Review and Data Mining Project to Identify Associations between Stressors and Health Outcomes for Children (PRESENTATION)
Children are often more vulnerable than adults to the effects of environmental contaminants found in their everyday environments. Their dynamic growth and unique interactions with the built, natural, and social environments may result in a greater susceptibility to chemical and n...
A Method for Identifying Prevalent Chemical Combinations in the US Population (JOURNAL)
Through the food and water they ingest, the air they breathe, and the consumer products with which they interact at home and at work, humans are exposed to tens of thousands of chemicals, many of which have not been evaluated to determine their potential toxicities. In recent yea...
A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. (EXTRAMURAL DOCUMENT)
This collection of 3 AOPs describe varying outcomes of adversity dependent upon species in response to inhibition of thyroperoxidase (TPO) during development. Chemical inhibition of TPO, the molecular-initiating event (MIE), results in decreased thyroid hormone (TH) synthesis, a...
A Physiologically Based Kinetic Model of Rat and Mouse Gestation: Disposition of a Weak Acid ()
A physiologically based toxicokinetic model of gestation in the rat mouse has been developed. The model is superimposed on the normal growth curve for nonpregnant females. It describes the entire gestation period including organogenesis. The model consists of uterus, mammary tiss...
A Review of Non-Chemical Stressors and Their Importance in Cumulative Risk Assessment (PRESENTATION)
Cumulative exposure/risk assessments need to include non-chemical stressors as well as human activities and chemical data. Multiple stressor research can offer information on the interactions between chemical and non-chemical stressors needed for cumulative risk assessment resea...
A Review of Stressors from the Built and Natural Environments Impacting American Indian Children’s Health and Well-Being (PRESENTATION)
Exposures to chemical and non-chemical stressors from children’s environments during early development may contribute to differences in their health and well-being outcomes. Children from American Indian tribes may have a disproportionate burden of these stressors from thei...
A critical review of the postulated role of the non-essential amino acid, β-N-methylamino-L-alanine, in neurodegenerative disease in humans (JOURNAL)
The compound BMAA (β-N-methylamino-L-alanine) has been hypothesized to play a significant role in four serious neurological diseases in humans: Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC) found on Guam, and ALS, parkinsonism, and dementia that occur glob...
A mixture of 18 anti-androgens at concentrations below individual chemical effect levels produces reproductive tract malformations in the male rat (PRESENTATION)
This product is a regional conference abstract and award application. The abstract primarily serves as the application for the NCSOT PARC Award and secondarily as a poster abstract for the fall meeting of NCSOT at NIEHS.
A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health (JOURNAL)
Individual-level characteristics, including socioeconomic status, have been associated with poor metabolic and cardiovascular health; however, residential area-level characteristics may also independently contribute to health status. In the current study, we used hierarchical clu...
A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols (JOURNAL)
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although much technical guidance is available that describes how to develop category/analog approaches, practical principles...
AOP-driven Predictive Models for Carcinogenicity: an exercise in interoperable data application. (PRESENTATION)
Traditional methods and data sources for risk assessment are resource-intensive, retrospective, and not a feasible approach to address the tremendous regulatory burden of unclassified chemicals. As a result, the adverse outcome pathway (AOP) concept was developed to facilitate a ...
About the Exposure Factors Program ()
<p class="TDText">Since the first version of the EFH was released in 1989, the need for the most up-to-date and accurate data on exposure factors used in assessing exposure to contaminants in the environment is of high priority to exposure assessors throughout the U.S. The compl...
Acrolein-induced arrhythmias and autonomic imbalance due to early life persistent vitamin D deficiency in mice is mediated by the putative anti-aging factor klotho. (PRESENTATION)
Although epidemiological, human and animal data have conclusively linked air pollution exposure to adverse cardiovascular outcomes, the severity of responses depends on a number of intrinsic (diet, underlying disease, etc) and extrinsic (e.g. co-stressors) factors. As such, cardi...
Active vs. sedentary lifestyle from weaning to adulthood and susceptibility to ozone in rats (JOURNAL)
This is publication for a peer review journal.
Acute Gastroenteritis and Recreational Water: Highest Burden Among Young US Children (JOURNAL)
OBJECT I VES : To provide summary estimates of gastroenteritis risks and illness burden associated with recreational water exposure and determine whether children have higher risks and burden.METHODS: We combined individual participant data from 13 prospective cohorts at marine a...
Acute pulmonary and innate immunity health effects in mice inhaling cookstove emissions (PRESENTATION)
Background: Burning of solid-fuels in rudimentary stoves generates harmful emissions that contribute to poor indoor air quality and have detrimental impacts on human health. Acute health effects include respiratory and eye irritation, cough, acute lower respiratory infection and ...
Adult Hippocampal Neurogenesis is Impaired by Transient and Moderate Developmental Thyroid Hormone Disruption (JOURNAL)
Severe thyroid hormone (TH) deprivation during development impairs neurogenesis throughout the brain. The hippocampus also maintains a capacity for neurogenesis throughout life which is reduced in adult-onset hypothyroidism. This study examined hippocampal volume in the neonate a...