EPA Science Inventory

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Records with

  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 1 to 25 of 4115

2018
20170624 - In vitro data and in silico models for computational toxicology (Teratology Society ILSI HESI workshop) (PRESENTATION)
The challenge of assessing the potential developmental health risks for the tens of thousands of environmental chemicals is beyond the capacity for resource-intensive animal protocols. Large data streams coming from high-throughput (HTS) and high-content (HCS) profiling of biolog...
20170907- Computational embryology as an integrative platform for predictive DART (45th Conf of Europ Teratology Society) (PRESENTATION)
Chemical regulation is challenged by the large number of chemicals requiring assessment for potential human health and environmental impacts. For example, the USEPA lists more than 85,000 chemicals on its inventory of substances that fall under the Toxic Substances Control Act (T...
A Cellular Game of Telephone: Trans Tissue Reprogramming of Responses to Toxic Stimuli (PRESENTATION)
Exposure to air pollution is a leading cause of cardiopulmonary morbidity and mortality; however, while these effects outside the lung have been associated with aberrant oxidative stress and inflammation, the underlying molecular mechanisms are poorly understood. We hypothesized ...
Analysis of Total Food Intake and Composition of Individual's Diet Based on the U.S. Department of Agriculture's 1994-96, 1998 Continuing Survey of Food Intakes by Individuals (CSFII) (2005, Final Report) (PUBLISHED REPORT)
EPA released the final report, <i>Analysis of Total Food Intake and Composition of Individual’s Diet Based on USDA’s 1994-1996, 98 Continuing Survey of Food Intakes by Individuals (CSFII).</i> The consumption of food by the general population is a significant route of potential ...
Child-Specific Exposure Factors Handbook (2000, External Review Draft) (PUBLISHED REPORT)
Children are often more heavily exposed to environmental toxicants than adults. They consume more food and water and have higher inhalation rates per pound of body weight than adults. Young children play close to the ground and come into contact with contaminated soil outdoors an...
Child-Specific Exposure Factors Handbook (2006, External Review Draft) (PUBLISHED REPORT)
<img src="http://www.epa.gov/ncea/images/csefh_cover.gif" vspave="5" hspace="5" width="201" height="264" align="right" alt="Cover of the Child-Specific Exposure Factors Handbook"> Children are often more heavily exposed to environmental toxicants than adults. They consume more...
Child-Specific Exposure Factors Handbook (2008, Final Report) (PUBLISHED REPORT)
The National Center for Environmental Assessment Staff (NCEA) have prepared this handbook to provide information on various physiological and behavioral factors commonly used in assessing children’s exposure to environmental chemicals. Children have different exposure circumstanc...
Estimated Daily Average Per Capita Water Ingestion by Child and Adult Age Categories Based on USDA's 1994-96 and 1998 Continuing Survey of Food Intakes by Individuals (Journal Article) (JOURNAL)
Current water ingestion estimates are important for the assessment of risk to human populations of exposure to water-borne pollutants. This paper reports mean and percentile estimates of the distributions of daily average per capita water ingestion for 12 age range groups. The a...
Estimates of Water Ingestion for Women in Pregnant, Lactating and Non-Pregnant and Non-Lactating Child Bearing Age Groups Based on USDA's 1994-96, 1998 Continuing Survey of Food Intake by Individuals (Journal Article) (JOURNAL)
Women in the child bearing age of 15 to 44 years and, in particular, pregnant and lactating women in this age cohort are considered a sensitive subpopulation when assessing risk from ingestion of contaminated water because ingested contaminants may pose a risk not only to the mot...
Exposure Factors Handbook - Update (2009, External Review Draft) (PUBLISHED REPORT)
The mission of National Center for Environmental Assessment (NCEA) of EPA's Office of Research and Development is to provide guidance and risk assessments aimed at protecting human health and the environment. To accomplish this mission, NCEA works to develop and improve the mode...
Hospital visits for gastrointestinal Illness after a major water main break in 2010 (PRESENTATION)
Background/Aim Water main breaks can occur due to the stresses of an aging infrastructure and changing climate. Water main breaks are a public health concern because they can cause pressure transients (specifically, abrupt decreases in water pressure/flow in the pipeline), which ...
PUBLIC COMMENT ON THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 2018 FEDERAL PHYSICAL ACITIVTY GUIDELINES (PRESENTATION)
Title: Public Comment on Department of Health and Human Services (DHHS) 2018 Physical Activity Guidelines Author: Wayne E. Cascio, Director, Environmental Public Health Division, US EPA Abstract: In the 2008 Physical Activity Guidelines, the effects of air pollution and advers...
STANDARD EVALUATION PROCEDURES FOR SUBMITTED DEVELOPMENTAL NEUROTOXICITY DATA (PUBLISHED REPORT)
As a NAFTA-inspired multi-governmental initiative, experts from the US EPA (Office of Research and Development, Office of Pesticide Program, or OPP) and the PMRA (Pest Management Regulatory Agency) of Health Canada formed a working group to create a document that would serve as a...
Sex Differences in Placental Mitochondrial Function Associated with Ozone-Induced Fetal Growth Restriction (PRESENTATION)
Fetal growth restriction is a major underlying cause of infant mortality worldwide. Despite knowledge of risk factors for adverse pregnancy outcomes, the mechanisms that drive compromised growth during pregnancy have not been well established. Placental maladaptation, particularl...
To Each Their Own: Molecular Mechanisms of Inter-Individual Variability in Toxic Exposure Effects (PRESENTATION)
Traditional approaches to identifying susceptible populations have relied on factors such as age, genotype, and disease status to explain variability in exposure outcomes; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are t...
Update for Chapter 5 of the Exposure Factors Handbook: Soil and Dust Ingestion (PUBLISHED REPORT)
This update includes new information on soil and dust ingestion that has become available since the <em>Exposure Factors Handbook: 2011 Edition</em> was released. The recommended values have also been revised, as needed, to reflect the new information. This chapter explains the ...
2017
Identification of vascular disruptor compounds by a tiered analysis in ebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
20170422 - Programming microphysiological systems for children's health protection (SEBM meeting) (PRESENTATION)
Presentation: Programming microphysiological systems for children&amp;rsquo;s health protectionAuthors: Knudsen1 T, Klieforth2 B, and Slikker3 W Jr.1National Center for Computational Toxicology/EPA, Research Triangle Park NC2National Center for Environmental Research/EPA, Washing...
20170504 - Systems Toxicology of Embryo Development (9th Copenhagen Workshop) (PRESENTATION)
An important consideration for predictive toxicology is to identify developmental hazards utilizing mechanism-based in vitro assays (e.g., ToxCast) and in silico multiscale models. Steady progress has been made with agent-based models that recapitulate morphogenetic drivers for a...
A 21st Century Update on Neurotoxicity Risk Assessment (PRESENTATION)
In 1998, EPA published Guidelines for Neurotoxicity Risk Assessment as the basis for interpreting neurotoxicity results. At that time, the focus was on traditional toxicity testing and human clinical /epidemiological data. More recently, a change in approach to toxicity testing ...
A Framework for Assessing Health Risk of Environmental Exposures to Children (Final) (PUBLISHED REPORT)
EPA released the final report entitled, <i>A Framework for Assessing Health Risk of Environmental Exposures to Children</i>, which examines the impact of potential exposures during developmental lifestages and subsequent lifestages, while emphasizing the iterative nature of the a...
A Novel Framework for Characterizing Exposure-Related Behaviors Using Agent-Based Models Embedded with Needs-Based Artificial Intelligence (CSSSA2016) (PRESENTATION)
Descriptions of where and how individuals spend their time are important for characterizing exposures to chemicals in consumer products and in indoor environments. Herein we create an agent-based model (ABM) that is able to simulate longitudinal patterns in behaviors. By basing o...
A QSAR Model for Thyroperoxidase Inhibition and Screening of a Large Set of Environmental Chemicals (SOT) (PRESENTATION)
Thyroid hormones (THs) are critical modulators of a wide range of biological processes from neurodevelopment to metabolism. Well regulated levels of THs are critical during development and even moderate changes in maternal or fetal TH levels produce irreversible neurological defi...
A Systems-Level Approach to Characterizing Effects of ENMs in Terrestrial Organisms and Ecosystems (PRESENTATION)
Engineered nanomaterials (ENMs) represent a new regulatory challenge because of their unique properties and their potential to interact with ecological organisms at various developmental stages, in numerous environmental compartments. Traditional toxicity tests have proven to be...
A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health (JOURNAL)
Individual-level characteristics, including socioeconomic status, have been associated with poor metabolic and cardiovascular health; however, residential area-level characteristics may also independently contribute to health status. In the current study, we used hierarchical clu...