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  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
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Records 1 to 25 of 6228

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2020
20181114 - In Silico Dynamic Models for Developmental Toxicity (FutureTox) (PRESENTATION)
Computer modeling and simulation of complex dynamical systems can provide a virtual framework for translating biomolecular lesions into critical phenomena underlying developmental processes and toxicities. In silico cell agent-based models (ABMs) may be executed to simulate how b...
20190908 - Towards a Mechanistic Approach in Toxicology: Retinoic Acid Balance Disturbance Leading to Neural Tube Closure Defects - EuroTox 2019 (PRESENTATION)
Retinoid signaling plays an important role in vertebrate embryo-fetal development and its disruption is teratogenic. The retinoic acid (RA) pathway controls retinoid homeostasis and regulates embryonic cell fate via nuclear receptor (RAR, RXR) activation. The RA pathway thus serv...
20191103 - Variability in in vivo Toxicity Studies: Defining the upper limit of predictivity for models of systemic effect levels (SETAC NA) (PRESENTATION)
New approach methodologies (NAMs) to predict hazard are often evaluated via comparison to results from animal studies; however, variability in these in vivo reference data limits NAM accuracy. The US EPA Toxicity Reference Database (ToxRefDB) enables consideration of in vivo mamm...
A Case study on the utility of predictive toxicology tools in alternatives assessments for hazardous chemicals in children’s consumer products (JOURNAL)
Children’s consumer products represent an important exposure source for many toxicants. Chemicals of high concern, as designated by the Washington State Child Safe Product Act include phthalates, Bisphenol A (BPA) and parabens, among others. As regulation and reporting requ...
A Spatially-Varying Distributed Lag Model with Application to an Air Pollution and Term Low Birth Weight Study (JOURNAL)
Distributed lag models have been used to identify and estimate critical periods of exposure to air pollution during pregnancy (i.e., critical exposure windows) in studies of pregnancy outcomes. However, the majority of previous work in this area has ignored the possibility of spa...
A disposable acetylcholine esterase sensor for As(iii) determination in groundwater matrix based on 4-acetoxyphenol hydrolysis (JOURNAL)
There is a lack of field compatible analytical methods for the speciation of As(III) to characterize groundwater pollution at anthropogenic sites. To address this issue, an inhibition-based acetylcholine esterase (AchE) sensor was developed to determine As(III) in groundwater. 4-...
A multivariate extension of mutual information for growing neural networks. (JOURNAL)
Recordings of neural network activity in vitro are increasingly being used to assess the development of neural network activity and the effects of drugs, chemicals and disease states on neural network function. The high-content nature of the data derived from such recordings can ...
A snap-shot of reproductive and developmental toxicity of Perfluoroalkyl Substances (PFAS) (PRESENTATION)
Concerns for health effects of PFAS, primarily the perfluoroalkyl acids (PFAA) such as perfluoroalkyl sulfonates and perfluorocarboxylates have been raised for the past two decades. In response, a substantial body of literature is now available addressing the potential reproducti...
A systematic review and meta-analysis examining the interrelationships between chemical and non-chemical stressors and inherent characteristics in children with ADHD (JOURNAL)
Children may be more vulnerable to the combined interactions of chemical and non-chemical stressors from their built, natural, and social environments when compared to adults. Attention deficit/hyperactivity disorder (ADHD) is the most commonly diagnosed childhood neurodevelopmen...
A systematic review of the health effects associated with the inhalation of particle-filtered and whole diesel exhaust (JOURNAL)
Diesel exhaust is a complex mixture comprised of gases and particulate matter and is a major contributor to ambient air pollution. To reduce health risks, recent changes in diesel engine technology have significantly altered the composition of exhaust, primarily by lowering level...
A time-embedding network models the ontogeny of 23 hepatic drug metabolizing enzymes (JOURNAL)
Pediatric patients are at elevated risk of adverse drug reactions, and there is insufficient information on drug safety in children. Complicating risk assessment in children, there are numerous age-dependent changes in the absorption, distribution, metabolism, and elimination of ...
AMBIENT OZONE AND FINE PARTICULATE MATTER EXPOSURES AND AUTISM SPECTRUM DISORDER IN METROPOLITAN CINCINNATI, OHIO (JOURNAL)
Background: Epidemiological studies report fairly consistent associations between various air pollution metrics and autism spectrum disorder (ASD), with some elevated risks reported for different prenatal and postnatal periods. Objective: To examine associations between ASD and ...
Acute exposures, lifelong consequences: Metabolic effects of early-life ozone exposure. (PRESENTATION)
Presentation for Visiting Pulmonary Scholars symposium.
Adverse Outcome Pathways for Developmental Toxicity (BOOK CHAPTER)
Adverse Outcome Pathways (AOPs) (frameworks for organizing knowledge about the etiology of an adverse phenotypic outcome) for developmental toxicity are still in their infancy yet represent the culmination of literally centuries of thinking and experimentation. Throughout history...
Adverse health effects of per- and polyfluoroalkyl substances (PFAS) (PRESENTATION)
Per- and polyfluoroalkyl substances (PFAS) are a class of anthropogenic chemicals with wide industrial and consumer applications that have been in use for the past seven decades. These commercial compounds consist of a variety of precursors that can be terminally degraded to perf...
All-Ages Lead Model (AALM), Version 2.0 (External Review Draft) (DATA)
The All Ages Lead Model (AALM) predicts lead concentration in body tissues and organs of hypothetical individuals, based on a simulated lifetime of lead exposure. The purpose of the model is to provide risk assessors and researchers with a tool for rapidly evaluating the impact o...
An overview of the updated and annotated fathead minnow genome (PRESENTATION)
The Fathead Minnow (FHM; Pimephales promelas) is an important and widely used organism in aquatic toxicology. Modern 'omics methods are being employed to characterize FHM responses to toxicants, and the genetic basis of differences in stressor susceptibility. These efforts have b...
Analysis of repeated leukocyte DNA methylation assessments reveals persistent epigenetic alterations after an incident myocardial infarction (JOURNAL)
Background Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has been little to no research into the molecular changes that...
Androgen Receptor Inhibition by Brominated Flame Retardants (PRESENTATION)
Flame retardants are chemical mixtures added to materials after manufacturing to reduce the amount of time it would take a small open flame to ignite the item. These compounds are volatile and continuously leach out of materials into the environment. Therefore, they are ubiquitou...
Arsenic Speciation of Contaminated Soils/Solid Wastes and Relative Oral Bioavailability in Swine and Mice (JOURNAL)
Arsenic (As) is one of the most widespread, toxic elements in the environment, and human activities have resulted in a large number of contaminated areas. However abundant, the potential of As toxicity from exposure to contaminated soils is limited to the fraction that will disso...
Assessing Metal Mobilization from Industrially Lead-Contaminated Soils Located at an Urban Site (JOURNAL)
A series of leaching and partitioning tests (Toxicity Characteristic Leaching Procedure (TCLP), Synthetic Precipitation Leaching Procedure (SPLP), Controlled Acidity Leaching Protocol (CALP), Acid Neutralization Capacity (ANC), and sequential extraction) were applied to three dif...
Assessing Portable Analyzers for Lead Testing in School Drinking Water (PRESENTATION)
Portable field analyzers may provide simple, rapid, low-cost lead measurements in drinking water samples compared to standard laboratory instruments. However, they may miss the particulate fraction of lead resulting in false assurance the water is safe. This presentation highligh...
Associations between PM2.5 and risk of preterm birth among liveborn infants (JOURNAL)
Recent studies suggest that exposure to ambient particulate matter less than 2.5 μg/m3 in aerodynamic diameter (PM2.5) is associated with increased risk of preterm births (PTB). We investigated the relationship between PM2.5 and PTBs, using singleton controls born from January 19...
Associations between fine particulate matter, extreme heat events and congenital heart defects (JOURNAL)
Previous research report associations between prenatal air pollution and the occurrence of congenital heart defects (CHD) in offspring. Extreme heat events (EHE) may modify the effect of air pollution on CHD risk during pregnancy. The objective of this research was to estimate th...
Beta-2 adrenergic and glucocorticoid receptor agonists modulate ozone-induced pulmonary protein leakage and inflammation in healthy and adrenalectomized rats (JOURNAL)
We have shown that acute ozone inhalation activates sympathetic-adrenal-medullary and hypothalamus-pituitary-adrenal stress axes, and adrenalectomy (AD) inhibits ozone-induced lung injury and inflammation. Therefore, we hypothesized that stress hormone receptor agonists (β2 ...
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