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Records with

  • Keyword = virtual tissue.
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Records 26 to 50 of 54

Toxicokinetic and Dosimetry Modeling Tools for Exposure Reconstruction: US EPA's Rapid Exposure and Dosimetry (RED) Project
(PRESENTATION) [Presented : Feb 16, 2017]
New technologies and in vitro testing approaches have been valuable additions to risk assessments that have historically relied solely on in vivo test results. Compared to in vivo methods, in vitro high throughput screening (HTS) assays are less expensive, faster and can provide ...
Microcephaly: computational and organotypic modeling of a complex human birth defect (UNC-CH Adv. Tox. lecture)
(PRESENTATION) [Presented : Apr 18, 2016]
lecture discusses computational and organotypic models of microcephaly in an AOP Framework and ToxCast assays.
A Liver-centric Multiscale Modeling Framework for Xenobiotics
(JOURNAL) [Published : Sep 16, 2016]
We describe a multi-scale framework for modeling acetaminophen-induced liver toxicity. Acetaminophen is a widely used analgesic. Overdose of acetaminophen can result in liver injury via its biotransformation into toxic product, which further induce massive necrosis. Our study foc...
Development of a 3D co-culture model using human stem cells for studying embryonic palatal fusion.
(PRESENTATION) [Presented : Jun 29, 2016]
Morphogenetic tissue fusion is a critical and complex event in embryonic development and failure of this event leads to birth defects, such as cleft palate. Palatal fusion requires adhesion and subsequent dissolution of the medial epithelial layer of the mesenchymal palatal shelv...
Computer Simulation of Embryonic Systems: What can a virtual embryo teach us about developmental toxicity? (LA Conference on Computational Biology & Bioinformatics)
(PRESENTATION) [Presented : Apr 01, 2016]
This presentation will cover work at EPA under the CSS program for: (1) Virtual Tissue Models built from the known biology of an embryological system and structured to recapitulate key cell signals and responses; (2) running the models with real (in vitro) or synthetic (in silico...
Developmental Systems Toxicology: computer simulation in a ‘Virtual Embryo’ prototype (SEURAT-1 Progress Meeting)
(PRESENTATION) [Presented : Dec 04, 2015]
Evaluating and assessing impacts to development is an Agency priority (EPA’s Children’s Environmental Health Research Roadmap); however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studi...
Agent-Based Computational Modeling of Cell Culture: Understanding Dosimetry In Vitro as Part of In Vitro to In Vivo Extrapolation
(PRESENTATION) [Presented : Mar 17, 2016]
Quantitative characterization of cellular dose in vitro is needed for alignment of doses in vitro and in vivo. We used the agent-based software, CompuCell3D (CC3D), to provide a stochastic description of cell growth in culture. The model was configured so that isolated cells assu...
Microphysiological models of the developing nervous system (SOT workshop session overview)
(PRESENTATION) [Presented : Mar 24, 2015]
Recent advances using human stem cells and other cells that can be ushered through differentiation and developmental maturation offer an unprecedented opportunity to develop predictive systems for toxicological assessment. The use of human cells is an advantage because there is n...
High-throughput PBPK and Microdosimetry: Cell-level Exposures in a Virtual Tissue Context (WC9)
(PRESENTATION) [Presented : Aug 26, 2014]
Toxicokinetic (TK) models can determine whether chemical exposures produce potentially hazardous tissue concentrations. Tissue microdosimetry TK models relate whole-body chemical exposures to cell-scale concentrations. As a proof of concept, we approximated the micro-anatomic arc...
Revolution In Toxicity Testing And Risk Prediction For Chemicals In The Environment (ASA)
(PRESENTATION) [Presented : Apr 08, 2014]
Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing; however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studies. Newer in vitro and in s...
Revolutionizing Toxicity Testing For Predicting Developmental Outcomes (DNT4)
(PRESENTATION) [Presented : May 14, 2014]
Characterizing risk from environmental chemical exposure currently requires extensive animal testing; however, alternative approaches are being researched to increase throughput of chemicals screened, decrease reliance on animal testing, and improve accuracy in predicting adverse...
Toxicity of Vascular Disrupting Chemicals to Developing Zebrafish
(PRESENTATION) [Presented : Nov 21, 2013]
Vascular development is integral to proper embryonic development and disruption of that process can have serious developmental consequences. We performed static 48-hr exposures of transgenic TG(kdr:EGFP)s843 zebrafish (Danio rerio) embryos with the known vascular inhibitors Vatal...
A Computational Model Predicting Disruption of Blood Vessel Development
(JOURNAL) [Published : Apr 04, 2013]
Vascular development is a complex process regulated by dynamic biological networks that vary in topology and state across different tissues and developmental stages. Signals regulating de novo blood vessel formation (vasculogenesis) and remodeling (angiogenesis) come from a varie...
Predictive Modeling and Computational Toxicology
(BOOK CHAPTER) [Published : Dec 01, 2011]
Embryonic development is orchestrated via a complex series of cellular interactions controlling behaviors such as mitosis, migration, differentiation, adhesion, contractility, apoptosis, and extracellular matrix remodeling. Any chemical exposure that perturbs these cellular proce...
Developmental toxicity testing for safety assessment: new approaches and technologies
(JOURNAL) [Published : Oct 17, 2011]
The ILSI Health and Environmental Sciences Institute's Developmental and Reproductive Toxicology Technical Committee held a 2-day workshop entitled "Developmental Toxicology-New Directions" in April 2009. The fourth session of this workshop focused on new approaches and technolog...
Zebrafish – As an Integrative Model for Twenty-first Century Toxicity Testing
(JOURNAL) [Published : Sep 01, 2011]
The zebrafish embryo is a useful small model for investigating vertebrate development because of its transparency, low cost, transgenic and morpholino capabilities, conservation of cell signaling, and concordance with mammalian developmental phenotypes. From these advantages, the...
Systems Modeling in Developmental Toxicity
(BOOK CHAPTER) [Published : May 03, 2011]
An individual starts off as a single cell, the progeny of which form complex structures that are themselves integrated into progressively larger systems. Developmental biology is concerned with how this cellular complexity and patterning arises through orchestration of cell divi...
Simulating Microdosimetry in a Virtual Hepatic Lobule
(JOURNAL) [Published : Apr 01, 2010]
The liver plays a key role in removing harmful chemicals from the body and is therefore often the first tissue to suffer potentially adverse consequences. To protect public health it is necessary to quantitatively estimate the risk of long-term low dose exposure to environmental ...
Virtual Tissues and Developmental Systems Biology (book chapter)
(BOOK CHAPTER) [Published : Jun 01, 2010]
Virtual tissue (VT) models provide an in silico environment to simulate cross-scale properties in specific tissues or organs based on knowledge of the underlying biological networks. These integrative models capture the fundamental interactions in a biological system and enable ...
Applications of Computational Toxicology to the Understanding of Risks of Developmental Toxicity
(PRESENTATION) [Presented : Jul 01, 2009]
In response to a request from US EPA, the National Research Council (NRC) developed a long-range vision and strategic plan for the future of toxicity testing in the 21st century. The report, published in 2007, called for a transformation in toxicology that would provide a more r...
PBPK Models, BBDR Models, and Virtual Tissues: How Will They Contribute to the Use of Toxicity Pathways in Risk Assessment?
(PRESENTATION) [Presented : May 12, 2009]
Accuracy in risk assessment, which is desirable in order to ensure protection of the public health while avoiding over-regulation of economically-important substances, requires quantitatively accurate, in vivo descriptions of dose-response and time-course behaviors. This level of...
Methodology for Uncertainty Analysis of Dynamic Computational Toxicology Models
(PRESENTATION) [Presented : Sep 30, 2009]
The task of quantifying the uncertainty in both parameter estimates and model predictions has become more important with the increased use of dynamic computational toxicology models by the EPA. Dynamic toxicological models include physiologically-based pharmacokinetic (PBPK) mode...
EPAs Virtual Embryo: Modeling Developmental Toxicity
(PRESENTATION) [Presented : Sep 30, 2009]
Embryogenesis is regulated by concurrent activities of signaling pathways organized into networks that control spatial patterning, molecular clocks, morphogenetic rearrangements and cell differentiation. Quantitative mathematical and computational models are needed to better unde...