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Records with

  • Keyword = virtual tissue.
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Records 1 to 25 of 57

Engineering a Computable Epiblast for in silico Gastrulation and Predictive Modeling of Developmental Toxicity with in vitro Data from the ToxCast Stem Cell Assay
(PRESENTATION) [Presented : May 11, 2022]
            New Approach Methods (NAMs) for assessing chemical effects on prenatal development with less reliance on animal testing is an important challenge for predictive toxicology at the USEPA [
Computational Simulation: agent-based modeling of neurovascular development
(PRESENTATION) [Presented : Apr 08, 2020]
For predictive toxicology, in vitro data and biological information must be organized and assimilated into computer models that bridge different levels of biological organization. This concept has been demonstrated with several virtual tissue model prototypes that predict adverse...
New Approach Methods’ Model Analysis and Adverse Outcome Pathway Development Validating Retinoid Signaling Associated with Skeletal Dysmorphogenesis
(PRESENTATION) [Presented : Oct 14, 2021]
All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors, leading to fetal skeleton malformations. Adverse Outcome Pathway (AOP) frameworks for ATRA metabolism, signaling, and homeostasis...
Challenges and Opportunities for Translational Research on Congenital Anomalies of External Genitalia:Summary of an NIDDK/AUA Workshop
(JOURNAL) [Published : Dec 01, 2020]
Summary: Congenital anomalies of the external genitalia (CAEG) are a prevalent and serious public health concern with lifelong impacts on the urinary function, sexual health, fertility, tumor development, and psychosocial wellbeing of affected individuals. Complications of treat...
Teratogenesis at the single-cell level: opportunities and challenges
(PRESENTATION) [Presented : Jul 01, 2020]
This presentation will provide a general overview of the scientific rationale and main concepts behind single cell RNA profiling (scRNA-seq) for comprehensive interrogation of genomic function. scRNA-seq enables high-resolution cell lineage maps (continuum gene expression manifol...
Bridging the Data Gap from in vitro Toxicity Testing to Chemical Safety Assessment through Computational Modeling
(JOURNAL) [Published : Sep 11, 2018]
Chemical toxicity testing is moving steadily toward a human cell and organoid-based in vitro approach for reasons including scientific relevancy, efficiency, cost, and ethical rightfulness. Inferring human health risk from chemical exposure based on in vitro testing data is a cha...
Future of Reproductive and Developmental Toxicity Testing: computational and organoids
(PRESENTATION) [Presented : May 17, 2019]
This joint American College of Toxicology/Teratology Society courseon Practical Reproductive and Developmental Toxicology is designed to provide a basic understanding in reproductive and developmental biology and principles of various testing approaches for reproductive and devel...
5.22 - Systems Toxicology and Virtual Tissue Models
(BOOK CHAPTER) [Published : May 01, 2018]
Cells in developing tissues must integrate and respond to highly dynamic information in the form of metabolic intermediates, genetic signals, and molecular gradients. Understanding the cellular decision-making process, and how these decisions may be perturbed by genetic errors or...
[Published : Feb 13, 2006]
System biology models holistically describe, in a quantitative fashion, the relationships between different levels of a biologic system. Relationships between individual components of a system are delineated. System biology models describe how the components of the system inter...
Development of an organotypic stem cell model for the study of human embryonic palatal fusion
(JOURNAL) [Published : Oct 16, 2018]
Cleft palate (CP) is a common birth defect, occurring in an estimated 1 in 1000 births worldwide. The secondary palate is formed by paired palatal shelves that grow toward each other, appose, attach and fuse. CP can result from disruption of any of these processes. The palatal sh...
A Three-Dimensional Organoid Culture Model to Assess the Influence of Chemicals on Morphogenetic Fusion.
(JOURNAL) [Published : Dec 01, 2018]
Organogenesis in the embryo involves cell differentiation and organization events that are unique to each tissue and organ and are susceptible to developmental toxicants. Animal models are the gold standard for identifying putative teratogens, but the limited throughput of develo...
Planning on EPA Virtual Tissue Modeling Systems (VTM) to produce quantitative cellular, tissue and phenotypic responses
(PRESENTATION) [Presented : May 23, 2018]
Chemical regulation under the Frank R. Lautenberg Chemical Safety for the 21st Century Act of 2016 requires affirmation of ‘low’ and ‘high’ priority substances based on unreasonable risk to vulnerable subpopulations and lifestages. New approach methods (NAMs) based on in vitro da...
Computational Embryology: Agent-Based Modeling and Simulation of External Genital Development
(PRESENTATION) [Presented : Jun 01, 2018]
Presentation of the US EPA's Virtual Tissue Model project using agent-based models (ABMs). ABMs can execute simulations that self-organize cells into high levels of biological structure and function (emergent phenotypes), and simulate perturbations in the system-dose or stage res...
Computational Embryology: Translational Tools for Modeling in vitro Data
(PRESENTATION) [Presented : Apr 18, 2018]
Virtual tissue models use new computational methods to construct advanced computer models capable of simulating how chemicals may affect human development. Virtual tissue models are some of the most advanced methods being developed today. The models will help reduce dependence on...
Comparing Toxicological Tipping Points from High-Content Imaging to Rat Subchronic Hepatoxicity Doses
(PRESENTATION) [Presented : Mar 15, 2018]
A major challenge to using in vitro high-throughput screening (HTS) data in risk assessment is the identification of toxicological “tipping points” between adaptation and adversity. Toxicological tipping points represent a systems threshold, or critical point, beyond which biolog...
Computational Modeling of Developmental Toxicity: Modeling with Human Pluripotent Stem Cells
(PRESENTATION) [Presented : Oct 11, 2017]
Presentation at Brazialian Congress of Toxicology on Computational Modeling of Developmental Toxicity: Modeling with Human Pluripotent Stem Cells
Computational Modeling of Developmental Toxicity
(PRESENTATION) [Presented : Oct 06, 2017]
Presentation at International Conference on Reproductive Biology and Toxicology Oct 2017 on Computational Biology
Profiling the ToxCast library with a pluripotent human (H9) embryonic stem cell assay
(PRESENTATION) [Presented : Mar 15, 2018]
The Stemina devTOX quickPredict platform (STM) is a human pluripotent H9 stem cell-based assay that predicts developmental toxicants. Using the STM model, we screened 1065 ToxCast chemicals and entered the data into the ToxCast data analysis pipeline. Model performance was 83.3% ...
Virtual Embryo: Cell-Agent Based Modeling of Developmental Processes and Toxicities (CSS BOSC)
(PRESENTATION) [Presented : Nov 18, 2016]
Spatial regulation of cellular dynamics is fundamental to morphological development. As such, chemical disruption of spatial dynamics is a determinant of developmental toxicity. Incorporating spatial dynamics into AOPs for developmental toxicity is desired but constrained by the ...
Chemical and HTS Profiling of 63 Cleft Palate Teratogens from ToxCast (FutureTox III)
(PRESENTATION) [Presented : Nov 19, 2015]
Cleft palate is a common human birth defect that has been linked to both genetic and environmental factors. To characterize the potential molecular targets and biological processes across mechanistically diverse teratogens that cause cleft palate, we mined the ToxCast high-throug...
Multiscale modeling and simulation of embryogenesis for in silico predictive toxicology (WC9)
(PRESENTATION) [Presented : Aug 25, 2014]
Translating big data from alternative and HTS platforms into hazard identification and risk assessment is an important need for predictive toxicology and for elucidating adverse outcome pathways (AOPs) in developmental toxicity. Understanding how chemical disruption of molecular ...
Identifying Key Events in AOPs for Embryonic Disruption using Computational Toxicology (European Teratology Society - AOP symp.)
(PRESENTATION) [Presented : Sep 01, 2014]
Addressing safety aspects of drugs and environmental chemicals relies extensively on animal testing; however, the quantity of chemicals needing assessment and challenges of species extrapolation require alternative approaches to traditional animal studies. Newer in vitro and in s...
Computational Systems Toxicology: recapitulating the logistical dynamics of cellular response networks in virtual tissue models (Eurotox_2017)
(PRESENTATION) [Presented : Sep 13, 2017]
Translating in vitro data and biological information into a predictive model for human toxicity poses a significant challenge. This is especially true for complex adaptive systems such as the embryo where cellular dynamics are precisely orchestrated in space and time. Computer ce...
The Role of Epigenomics in Aquatic Toxicology
(JOURNAL) [Published : Oct 01, 2017]
Over the past decade, the field of molecular biology has rapidly incorporated epigenetic studies to evaluate organism–environment interactions that can result in chronic effects. Such responses arise from early life stage stress, the utilization of genetic information over ...
Adverse Outcome Pathway (AOP) framework for embryonic vascular disruption and developmental defects (SOT)
(PRESENTATION) [Presented : Mar 16, 2017]
Vascular development commences with de novo assembly of a primary capillary plexus (vasculogenesis) followed by its expansion (angiogenesis) and maturation (angio-adaptation) into a hierarchical system of arteries and veins. These processes are tightly regulated by genetic signal...