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  • Keyword = endocrine disruption.
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Records 1 to 25 of 343

A GLOBAL PERSPECTIVE ON ENDOCRINE DISRUPTION, WITH COMMENTS ON THE US EXPERIENCE (PRESENTATION)
The last two decades have witnessed a growing concern for chemicals that have the potential to adversely affect the normal functioning of the endocrine system. The International Programme on Chemical Safety (IPCS) of the World Health Organization has recently reviewed the curren...
BIOMARKERS OF ENDOCRINE DISRUPTION AT THE MRNA LEVEL (PRESENTATION)
Denslow, Nancy D., Christopher J. Bowman, Gillian Robinson, H. Stephen Lee, Ronald J. Ferguson, Michael J. Hemmer and Leroy C. Folmar. 1999. Biomarkers of Endocrine Disruption at the mRNA Level. In: Environmental Toxicology and Risk Assessment: Standardization of Biomarkers for ...
MODELING MOLECULAR TARGETS FOR TOXICITY, A COMPUTATIONAL APPROACH TO UNDERSTANDING KEY STEPS IN THE MECHANISMS FOR TOXICITY AND A TOOL FOR PRIORITIZING BIOASSAY REQUIREMENTS ()
The Agency frequently encounters situations where it must make decisions about the potential health and environmental effects of chemicals when all of the relevant data is not available. One rational approach to this problem is to estimate the relevant missing information by ext...
Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish (JOURNAL)
Pharmaceuticals and personal care products (PPCPs) are emerging contaminants that have been found ubiquitously in wastewater and surface waters around the world. A major source of these compounds is incomplete metabolism in humans and subsequent excretion in human waste. PPCPs th...
Presentations: In vitro Evaluation of Steroidogenesis: H295R Assay and EDSP overview( 11th annual US-Japan Bilateral Meeting on Endocrine Disruption) (PRESENTATION)
Two presentations attached
Using Gene Expression Biomarkers to Identify Chemicals that Induce Key Events in Cancer and Endocrine Disruption AOPs: Androgen Receptor as an Example (PRESENTATION)
High-throughput transcriptomic (HTTr) technologies are increasingly being used to screen environmental chemicals in vitro to provide mechanistic context for regulatory testing. The development of gene expression biomarkers that accurately predict molecular and toxicological effec...
Using Gene Expression Biomarkers to Identify Chemicals that Induce Key Events in Cancer and Endocrine Disruption Adverse Outcome Pathways: Androgen Receptor as an Example (PRESENTATION)
High-throughput transcriptomic (HTTr) technologies are increasingly being used to screen environmental chemicals in vitro to provide mechanistic context for regulatory testing. The development of gene expression biomarkers that accurately predict molecular and toxicological effec...
ARRAY TECHNOLOGY AS A TOOL TO MONITOR ENDOCRINE DISRUPTION IN WILD FISH POPULATIONS (JOURNAL)
A variety of anthropogenic chemicals are capable of binding to the estrogen receptor of vertebrate species. Binding of these compounds can interfere with homeostasis by disrupting normal gene expression patterns. The purpose of this study was to investigate the feasibility of ap...
CHARACTERIZATION OF ENDOCRINE-DISRUPTION AND CLINICAL MANIFESTATIONS IN LARGE-MOUTH BASS FROM FLORIDA LAKES (PRESENTATION)
Previous efforts from this laboratory, have documented altered endocrine function and sexual differentiation for alligators and turtles from Lake Apopka in Central Florida. This lake has been exposed to a variety of contaminants which are potentially endocrine-disrupting. Therefo...
CONTAMINANT-ASSOCIATED ENDOCRINE DISRUPTION IN REPTILES. (BOOK CHAPTER)
The data presented suggest that contaminants can alter the endocrine and reproductive system of reptiles by mimicking hormones and by various mechanisms other than direct hormonal mimicry. However, these data indicate, as do many other studies using various vertebrates, that a fo...
Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, Focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways (ASSESSMENT DOCUMENT)
The focus of this meeting is the SAP's review and comment on the Agency's proposed high-throughput computational model of androgen receptor pathway activity as an alternative to the current Tier 1 androgen receptor assay (OCSPP 890.1150: Androgen Receptor Binding Rat Prostate Cyt...
FIELD ASSESSMENT FOR ENDOCRINE DISRUPTION IN INVERTEBRATES (BOOK CHAPTER)
There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field.
FIELD MONITORING FOR ENDOCRINE DISRUPTION IN INVERTEBRATES (BOOK CHAPTER)
The field monitoring chapter addresses the following issues: cases where endocrine disruption (ED) has been identified as causing effects in either individuals, populations, or communities in the field; practical...
GONADAL HISTOLOGY AND CHARACTERISTIC HISTOPATHOLOGY ASSOCIATED WITH ENDOCRINE DISRUPTION IN THE ADULT FATHEAD MINNOW (PIMEPHALES PROMELAS) (JOURNAL)
Examination of gonadal histopathology has been beneficial in understanding and assessing the effects of potential endocrine-disrupting chemicals in fish and other organisms...
INTERACTIONS BETWEEN THYROID AND CORTICOSTEROID SYSTEMS DURING THE EARLY LIFE HISTORY OF AN ESTUARINE DEPENDENT FISH: A POSSIBLE TARGET FOR ENDOCRINE DISRUPTION BY ATRAZINE ()
<p> This research will determine whether interactions between the thyroid and corticosteroid systems are consistent throughout the early life history of marine fish, or whether such interactions vary during development. This study will indicate whether endocrine related gene expr...
NMR-BASED METABOLOMIC STUDIES OF ENDOCRINE DISRUPTION IN SMALL FISH MODELS (PRESENTATION)
Metabolomics is now being widely used to obtain complementary information to genomic and proteomic studies. Among the various approaches used in metabolomics, NMR spectroscopy is particularly powerful, in part because it is relatively non-selective, and is amenable to the study o...
SCREENING AND TESTING FOR ENDOCRINE DISRUPTION IN FISH - BIOMARKERS AS "SIGNPOSTS," NOT "TRAFFIC LIGHTS," IN RISK ASSESSMENT (JOURNAL)
Biomarkers provide important tools for addressing the impacts of endocrine disrupting chemicals (EDCs) in fish. Presently, biomarkers are best used as mechanistic "signposts" rather than as "red traffic lights" in the environmental risk assessment of EDCs. In field studies, bio...
STEROID HORMONES AS BIOMARKERS OF ENDOCRINE DISRUPTION IN WILDLIFE. IN: ENVIRONMENTAL TOXICOLOGY AND RISK ASSESSMENT (PRESENTATION)
Standardization of Biomarkers for Endocrine Disruption and Environmental Assessment. 8th Volume, ASTM STP 1364. D.S. Henshel, M.C. Black, and M.C. Harrass, Editors. American Society for Testing and Materials, West Conshohocken, PA. Pp. 254-270.
TOXICITY PREDICTION TOOLS FOR ENDOCRINE DISRUPTION (PRESENTATION)
A key step is to determine whether these chemicals bind to hormone receptors, and if so, what the strength of the interaction is between the chemical and the receptor
Uncertainty Quantification in High Throughput Screening: Applications to Models of Endocrine Disruption, Cytotoxicity, and Zebrafish Development (GRC Drug Safety) (PRESENTATION)
Using uncertainty quantification, we aim to improve the quality of modeling data from high throughput screening assays for use in risk assessment. ToxCast is a large-scale screening program that analyzes thousands of chemicals using over 800 assays representing hundreds of bioche...
A METABOLOMIC APPROACH TO UNDERSTANDING ENDOCRINE DISRUPTION IN FATHEAD MINNOW (PRESENTATION)
Although widely used in the study of rodent toxicity responses to assess human risk, metabolomics is now finding utility in toxicity assessments in a wide variety of other organisms including environmentally relevant small fish species such as fathead minnow (FHM) and medaka. To...
A METABOLOMIC APPROACH TO UNDERSTANDING ENDOCRINE DISRUPTION IN FATHEAD MINNOW (PRESENTATION)
Although widely used in the study of rodent toxicity responses to assess human risk, metabolomics is now finding utility in toxicity assessments in a wide variety of other organisms including environmentally relevant small fish species such as fathead minnow (FHM) and medaka. To...
AN INTEGRATION OF COPEPOD-BASED BAFS, LIFECYCLE TOXICITY TESTING, AND ENDOCRINE DISRUPTION METHODOLOGIES FOR RAPID POPULATION-LEVEL RISK ASSESSMENT OF PERSISTENT BIOACCUMULATIVE TOXICANTS ()
Extensive multi-generational microplate culturing (copepod hatching stage through two broods) experiments were completed with the POPs lindane, DDD and fipronil sulfide.&nbsp; Identical tandem microplate experiments were run concurrently to yield sufficient copepod biomass for li...
AN INTERLABORATORY STUDY ON THE USE OF STERIOD HORMONES IN EXAMINING ENDOCRINE DISRUPTION. (JOURNAL)
In recent years, there has been an increased use of the measurement of sex steroid hormone levels in the blood of animals exposed to chemicals as an indicator of reproductive impairment or an alteration in endocrine function. Although levels of hormones are often compared among a...
AN INTERLABORATORY STUDY ON THE USE OF STEROID HORMONES IN EVALUATING ENDOCRINE DISRUPTION (JOURNAL)
In recent years, there has been an increased use of the measurement of sex steroid hormone levels in the blood of animals exposed to chemicals as an indicator of reproductive impairment or an alteration in endocrine function. Although levels of hormones are often compared among a...