EPA Science Inventory

Search Criteria:

Records with

  • Keyword = endocrine disruption.
  (Sorted by Fiscal Year)
Records 1 to 25 of 279

2018
CH 21: Toxic Responses of the Reproductive System (BOOK CHAPTER)
Any evaluation of toxicity to reproduction will have as an important consideration that events may not only be on the adults having impact on their likelihood to have children, but also impact the viability and quality of life of their potential offspring and feasibly even affect...
Computational Model of the Fathead Minnow Hypothalamic-Pituitary-Gonadal Axis: Incorporating Protein Synthesis in Improving Predictability of Responses to Endocrine Active Chemicals (JOURNAL)
There is international concern about chemicals that alter endocrine system function in humans and/or wildlife and subsequently cause adverse effects. We previously developed a mechanistic computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minno...
Describing the Quantitative Relationships between the MIEs, Key events and Adverse Outcomes in the Androgen AOP Network? (PRESENTATION)
none, this is a slide presenation
Epigenetic Mechanism Mediating the Regulation of the Estrogen Exposure Biomarker Vitellogenin in Zebrafish (PRESENTATION)
An increasing number of pharmaceuticals and industrial chemicals are being classified as endocrine disrupting compounds (EDCs). These chemicals can interfere with hormonal homeostasis and lead to developmental disorders, cancer and other pathologies. One such EDC is 17α-et...
Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption (PRESENTATION)
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces available iodide for thyroid hormone synthesis, which leads to hormone insufficiency...
Evolution of the Medaka Extended One Generation Reproduction Test (MEOGRT) (PRESENTATION)
In response to various legislative mandates, the United States Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, implemented a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and...
Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption (PRESENTATION)
In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...
Gene transcription ontogeny of thyroid-axis development in early-life stage fathead minnows (Pimephales promelas) (PRESENTATION)
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...
Impaired swim bladder inflation in early-life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid (article) (JOURNAL)
The present study investigated whether inhibition of deiodinase, the enzyme which converts thyroxine (T4) to the more biologically-active form, 3,5,3'-triiodothyronine (T3), would impact inflation of the posterior and/or anterior chamber of the swim bladder, processes previously ...
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling (JOURNAL)
Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) are readily found in the tissues of humans...
Summary of the development the US Environmental Protection Agency’s Medaka Extended One Generation Reproduction Test (MEOGRT) using data from 9 multigenerational medaka tests (JOURNAL)
In response to various legislative mandates the United States Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, implemented a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and ...
The use of adverse outcome pathway-based toxicity predictions: A case study evaluating the effects of imazalil on fathead minnow reproduction (PRESENTATION)
Product Description: As a means to increase the efficiency of chemical safety assessment, there is an interest in using data from molecular and cellular bioassays, conducted in a highly automated fashion using modern robotics, to predict toxicity in humans and wildlife. The prese...
Validation of a Glucocorticoid Receptor Effects-Based Environmental Sample Screening Tool (PRESENTATION)
Abstract describing study and results that will be presented in a seminar presentation to members of UNC-Chapel Hill Curriculum in Toxicology. This seminar presentation will be fulfilling the requirements of the USEPA-UNC Toxicology Cooperative Postdoctoral Training program.
2017
(Chemical Research in Toxicology) Development and Validation of a Computational Model for Androgen Receptor Activity (JOURNAL)
Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods. High-throughput in vitro screening (HTS) and computational toxicology approaches can mo...
A High-Throughput Screening Assay to Detect Thyroperoxidase Inhibitors (Teratology Society) (PRESENTATION)
In support of the Endocrine Disruption Screening Program (EDSP21), the US EPA ToxCast program is developing assays to enable screening for chemicals that may disrupt thyroid hormone synthesis. Thyroperoxidase (TPO) is critical for TH synthesis and is a known target of thyroid-dis...
A QSAR Model for Thyroperoxidase Inhibition and Screening of a Large Set of Environmental Chemicals (SOT) (PRESENTATION)
Thyroid hormones (THs) are critical modulators of a wide range of biological processes from neurodevelopment to metabolism. Well regulated levels of THs are critical during development and even moderate changes in maternal or fetal TH levels produce irreversible neurological defi...
A tiered approach to evaluate an iodine recycling inhibition adverse outcome pathway (AOP) in amphibians (PRESENTATION)
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces thyroid hormone synthesis, which leads to insufficiency in tissues and subsequent ne...
Adverse outcome pathways (AOPs) to enhance EDC screening and testing: Overview of recent activities and future efforts (PRESENTATION)
Screening and testing for endocrine active chemicals was mandated under 1996 amendments to the Safe Drinking Water Act and Food Quality Protection Act. Efficiencies can be gained in the endocrine disruptor screening program by using available biological and toxicological knowledg...
An integrated approach for identifying priority contaminant in the Great Lakes Basin -Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern (JOURNAL)
Environmental assessment of complex mixtures typically requires integration of chemical and biological measurements. This study demonstrates the use of a combination of instrumental chemical analyses, effects-based monitoring, and bio-effects prediction approaches to help identi...
Application of computational and high-throughput in vitro screening for prioritization (ECHA workshop) (PRESENTATION)
Abstract: There are tens of thousands of man-made chemicals to which humans are exposed, but only a fraction of these have the extensive in vivo toxicity data used in most traditional risk assessments. This lack of data, coupled with concerns about testing costs and animal use, a...
Avoiding false positives and optimizing identification of true negatives in estrogen receptor binding and agonist/antagonist assays (JOURNAL)
The potential for chemicals to affect endocrine signaling is commonly evaluated via in vitro receptor binding and gene activation, but these assays, especially antagonism assays, have potential artifacts that must be addressed for accurate interpretation. Results are presented fr...
Computational modeling of the amphibian thyroid axis supported by targeted in vivo testing to advance quantitative adverse outcome pathway development (PRESENTATION)
In vitro screening of chemicals for bioactivity together with computational modeling are beginning to replace animal toxicity testing in support of chemical risk assessment. To facilitate this transition, an amphibian thyroid axis model has been developed to describe thyroid home...
Consensus models to predict endocrine disruption for all human-exposure chemicals (AAAS Annual Meeting) (PRESENTATION)
Humans are potentially exposed to tens of thousands of man-made chemicals in the environment. It is well known that some environmental chemicals mimic natural hormones and thus have the potential to be endocrine disruptors. Most of these environmental chemicals have never been te...
Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances (JOURNAL)
In this paper existing regulatory frameworks and test systems for assessing potential endocrine-active chemicals are described, and associated challenges discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across organizatio...
Developing confidence in adverse outcome pathway-based toxicity predictions effects of the fungicide imazalil on fathead minnow reproduction (PRESENTATION)
An adverse outcome pathway (AOP) description linking inhibition of aromatase (cytochrome P450 [cyp] 19) to reproductive dysfunction was reviewed for scientific and technical quality and endorsed by the OECD (https://aopwiki.org/wiki/index.php/Aop:25). An intended application of t...