EPA Science Inventory

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Records with

  • Keyword = endocrine disruption.
  (Sorted by Fiscal Year)
Records 1 to 25 of 324

2018
A Multi-Receptor and Multi-Species Assay for Potential Endocrine Disruptor Targets (SLAS meeting) (PRESENTATION)
Screening methods for detecting potential endocrine disrupting chemicals rely chiefly on transactivation assays targeting nuclear receptors such as the estrogen (ER) and androgen receptors (AR). These assays are predominately human-based; yet environmental exposure can affect div...
AOP-informed assessment of endocrine disruption in freshwater crustaceans (PRESENTATION)
To date, most research focused on developing more efficient and cost effective methods to predict toxicity have focused on human biology. However, there is also a need for effective high throughput tools to predict toxicity to other species that perform critical ecosystem functio...
An integrated approach for identifying priority contaminant in the Great Lakes Basin -Investigations in the Lower Green Bay/Fox River and Milwaukee Estuary areas of concern (JOURNAL)
Environmental assessment of complex mixtures typically requires integration of chemical and biological measurements. This study demonstrates the use of a combination of instrumental chemical analyses, effects-based monitoring, and bio-effects prediction approaches to help identi...
Assessing differences in sensitivity to aromatase inhibitors among freshwater fish species (PRESENTATION)
There is significant concern regarding potential impairment of fish reproduction associated with exposure to endocrine disrupting chemicals (EDCs). Aromatase is a steroidogenic enzyme involved in the conversion of androgens to estrogens. Inhibition of aromatase activity by exposu...
Avoiding false positives and optimizing identification of true negatives in estrogen receptor binding and agonist/antagonist assays (JOURNAL)
The potential for chemicals to affect endocrine signaling is commonly evaluated via in vitro receptor binding and gene activation, but these assays, especially antagonism assays, have potential artifacts that must be addressed for accurate interpretation. Results are presented fr...
Brominated flame retardants and perfluorinated chemicals (BOOK CHAPTER)
Brominated flame retardants (BFRs) and perfluorinated chemicals (PFCs) belong to a class of chemicals known as organohalogens. It is believed that use of both BFRs and PFCs has resulted in lives saved by reducing flammability of materials commonly used and also due to their bacte...
CH 21: Toxic Responses of the Reproductive System (BOOK CHAPTER)
Any evaluation of toxicity to reproduction will have as an important consideration that events may not only be on the adults having impact on their likelihood to have children, but also impact the viability and quality of life of their potential offspring and feasibly even affect...
Changes in CpG-methylation of Vitellogenin 1 in Adult Male Zebrafish After Exposure to 17α-ethynylestradiol (EE2) (PRESENTATION)
An increasing number of pharmaceutical and industrial chemicals are being classified as endocrine disrupting compounds (EDCs). These chemicals can interfere with hormonal homeostasis and lead to developmental disorders, cancer and other pathologies. One such EDC is 17α-ethy...
Computational Model of the Fathead Minnow Hypothalamic-Pituitary-Gonadal Axis: Incorporating Protein Synthesis in Improving Predictability of Responses to Endocrine Active Chemicals (JOURNAL)
There is international concern about chemicals that alter endocrine system function in humans and/or wildlife and subsequently cause adverse effects. We previously developed a mechanistic computational model of the hypothalamic-pituitary-gonadal (HPG) axis in female fathead minno...
Continuing Development of Alternative High-Throughput Screens to Determine Endocrine Disruption, Focusing on Androgen Receptor, Steroidogenesis, and Thyroid Pathways (ASSESSMENT DOCUMENT)
The focus of this meeting is the SAP's review and comment on the Agency's proposed high-throughput computational model of androgen receptor pathway activity as an alternative to the current Tier 1 androgen receptor assay (OCSPP 890.1150: Androgen Receptor Binding Rat Prostate Cyt...
Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances (JOURNAL)
In this paper existing regulatory frameworks and test systems for assessing potential endocrine-active chemicals are described, and associated challenges discussed, along with proposed approaches to address these challenges. Regulatory frameworks vary somewhat across organizatio...
Describing the Quantitative Relationships between the MIEs, Key events and Adverse Outcomes in the Androgen AOP Network? (PRESENTATION)
none, this is a slide presenation
Development and Validation of a Computational Model for Androgen Receptor Activity (JOURNAL)
Testing thousands of chemicals to identify potential androgen receptor (AR) agonists or antagonists would cost millions of dollars and take decades to complete using current validated methods. High-throughput in vitro screening (HTS) and computational toxicology approaches can mo...
Development of a Human 3D Prostate Microtissue Assay for Anti-androgen Screening (PRESENTATION)
Altered androgen hormone biosynthesis and metabolism can modulate androgen levels, contributing to endocrine disruption that may result in impaired reproductive and sexual development. Steroid 5α-reductase isozymes are expressed in key peripheral tissues and catalyze the conversi...
Ecdysone receptor agonism leading to lethal molting disruption in arthropods: Review and adverse outcome pathway development (JOURNAL)
Molting is a key biological process in growth, development, reproduction and survival in arthropods. Complex neuroendocrine pathways are involved in the regulation of molting and may potentially become targets of environmental endocrine disrupting compounds (EDCs). For example, s...
Effects of the antimicrobial contaminant triclocarban and co-exposure with the androgen 17â-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas) (JOURNAL)
Triclocarban (TCC) is a widely used antimicrobial agent that is routinely detected in surface waters. The present study was designed to examine TCC’s efficacy and mode of action as a reproductive toxicant in fish. Reproductively mature Pimephales promelas were continuously expose...
Epigenetic Mechanism Mediating the Regulation of the Estrogen Exposure Biomarker Vitellogenin in Zebrafish (PRESENTATION)
An increasing number of pharmaceuticals and industrial chemicals are being classified as endocrine disrupting compounds (EDCs). These chemicals can interfere with hormonal homeostasis and lead to developmental disorders, cancer and other pathologies. One such EDC is 17α-et...
Evaluating iodide recycling inhibition as a novel molecular initiating event for thyroid axis disruption (PRESENTATION)
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces available iodide for thyroid hormone synthesis, which leads to hormone insufficiency...
Evolution of the Medaka Extended One Generation Reproduction Test (MEOGRT) (PRESENTATION)
In response to various legislative mandates, the United States Environmental Protection Agency (USEPA) formed its Endocrine Disruptor Screening Program (EDSP), which in turn, implemented a tiered testing strategy to determine the potential of pesticides, commercial chemicals, and...
Extrapolation of mammalian-based ToxCast assay results to non-mammalian species to evaluate endocrine disruption (PRESENTATION)
In vitro high-throughput screening (HTS) and in silico technologies have emerged as 21st century tools for chemical hazard identification. In 2007 the U.S. Environmental Protection Agency (EPA) launched the ToxCast Program, which has screened thousands of chemicals in hundreds of...
From High-Throughput Toxicity Testing to Building Better Models to Predict Endocrine Disruption: Thyroperoxidase Case Study (PRESENTATION)
Presentation given at North Carolina State University Oct 31, 2017
Gene transcription ontogeny of hypothalamic-pituitary-thyroid-axis development in early-life stage fathead minnow and zebrafish (PRESENTATION)
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...
Gene transcription ontogeny of thyroid-axis development in early-life stage fathead minnows (Pimephales promelas) (PRESENTATION)
Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...
Generalized concentration addition mixtures model predicts glucocorticoid receptor activation by environmental full and partial agonist mixtures (PRESENTATION)
This abstract will be submitted for the consideration of either a poster or platform presentation at the 2018 Annual Carolinas Society of Environmental Toxicology and Chemistry held in Research Triangle Park, NC April 25-27th.
Genomic effects of androstenedione and sex-specific liver cancer susceptibility in mice (JOURNAL)
Current strategies for predicting carcinogenic mode of action for nongenotoxic chemicals are based on identification of early key events in toxicity pathways. The goal of this study was to evaluate short-term key event indicators resulting from exposure to androstenedione (A4), a...