Science Inventory

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This presentation summarizes some of our findings from a multi-stage project characterizing the effects of wildland fire exposure on children’s health. Specifically, the effects of preconception exposure to smoke were studied, and the proper reproductive development of the ...

Environmental pollutants capable of interfering with the thyroid hormone (TH) system increasingly raise concern for both human and environmental health. Recently, resorcinol has received attention as a compound of concern due to its endocrine disrupting properties. It is a known ...

Rapid, human relevant assays are needed to assess potential hazards of the many chemicals in commerce. An assay of thyroid peroxidase (TPO) inhibition, using the substrate Amplex Ultra Red, was recently adapted for human TPO (AUR-hTPO). We tested a large number (788) of chemicals...

Original submitted abstract for Symposium: Male reproductive impairments, such as hypospadias, cryptorchidism and reduced sperm counts, are relatively common and have reportedly been increasing in prevalence over the last several decades. These effects can be induced in laborator...

Bioinformatics is the combination of information science, mathematics, and biology to answer biological questions, typically pertaining to the exploration of large volumes of DNA and/or amino acid sequence data. The major advantages of such approaches are that complex data can be...

Chemical hazard characterization for ecological species within OCSPP's Endocrine Disruptor Screening Program (EDSP) currently consists of a battery of standardized in vivo and in vitro assays. The current battery makes use of a tiered approach with Tier 1 consisting of a group of...

Bioinformatics is the combination of information science, mathematics, and biology to answer biological questions, typically pertaining to the exploration of large volumes of DNA and/or amino acid sequence data. The major advantages of such approaches are that complex data can be...

No abstract for this meeting

Background and Purpose The EPA initiated the Endocrine Disruption Screening Program (EDSP) to identify chemicals interfering with the estrogen, androgen, and thyroid pathways in humans and wildlife. To modernize testing under the EDSP, EPA scientists devised computational models ...

Presentation to the Twin Ports Freshwater Folk Poster Session June 2023  

High-throughput screening (HTS) assays allow for rapidly testing many chemicals for bioactivity at specific molecular targets. One goal of HTS is to reduce the time and cost of generating data to support evaluation of chemicals for potential endocrine disruption. Data from these ...

Screening and testing of potential endocrine-disrupting chemicals for ecological effects can directly benefit through use of adverse outcome pathways (AOPs) to establish linkages between alterations in endocrine function measured using new approach methodologies and whole organis...

No abstract

Brominated flame retardants (BFRs) and per- and polyfluoroalkyl substances (PFASs) belong to a class of chemicals known as organo-halogens or halogenated organic chemicals (HOCs). These chemicals have benefited society in multiple capacities, including their life-saving anti-flam...

Presentation to the SETAC North America Annual Meeting November 2022. The adverse outcome pathway (AOP) framework and AOP-Wiki are designed to capture and disseminate synthesized knowledge and evidence concerning causal relationships between stressor-induced perturbation of ...

Background and Purpose The identification of chemicals with the potential to disrupt estrogen signaling is a key component of the EPA’s Endocrine Disruption Screening Program (EDSP). EPA researchers have worked to devise in vitro assays and computational models to serve as ...

Quantitative adverse outcome pathways (qAOPs) have been broadly defined as adverse outcome pathways (AOPs) for which the quantitative understanding of the key event relationships is sufficient to allow for estimation of the probability or severity of the adverse outcome occurring...

Although wastewater treatment facilities have dramatically improved water quality nationwide, wastewater effluents continue to be a significant source of anthropogenic contaminants to many aquatic ecosystems. The South Platte River near Denver, Colorado is representative of urban...

In previous studies, male fathead minnows (Pimephales promelas) were exposed to four PFAS that were shown to have estrogenic activity in vitro.  Based on results from these 4 d  in vivo tests, 1H,1H,10H,10H-Perfluorodecane-1,10-diol (FC10-diol) (DTXID50369896) was found...

Climate change has been associated with increased incidence and severity of wildland fires. With firefighters at greatest risk and in an occupation dominated by males of reproductive age, it is important to understand not only cardiopulmonary risks but reproductive health as well...

Background and Purpose: Quantifying endocrine disruption using in vitro high-throughput screening assays is a critical component of new approach method (NAM)-based chemical hazard identification and evaluation in regulatory decision-making. A commonly cited limitation of in vitro...

Exposures to chemicals in the environment are nearly always to complex mixtures. However, complex mixtures are not readily assessed through chemical monitoring and single chemical-based toxicity testing. Thus there is a need for effect-based monitoring approaches that can provide...

The development of innovative technologies and approaches is required to assess the thousands of previously untested chemicals for environmental or human health hazards. A central goal of the U.S. Environmental Protection Agency (EPA) Chemical Safety for Sustainability (CSS) rese...

Background and Purpose The 2016 Frank R. Lautenberg Chemical Safety for the 21st Century Act is an amendment to the Toxic Substances Control Act that directs the development and application of new approach methods (NAMs) to identify chemical hazards while reducing the use of vert...

High-throughput screening (HTS) assays allow for rapidly testing many chemicals for bioactivity at specific molecular targets. One goal of HTS is to reduce the time and cost of generating data to support evaluation of chemicals for potential endocrine disruption. Data from HTS as...