Science Inventory

Next >>

Understanding how sublethal impacts of toxicants affect population-relevant outcomes for organisms is challenging. We tested the hypotheses that the well-known sublethal impacts of methylmercury (MeHg) and a polychlorinated biphenyl (PCB126) would have meaningful impacts on cohor...

Despite structural and functional conservation across vertebrate species, the glucocorticoid receptor has been minimally studied in comparison to other biological targets for endocrine-disrupting compounds in aquatic systems. Because prolonged use of pharmaceutical glucocorticoid...

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous in both indoor and outdoor air, and there is increasing need to effectively screen this diverse class of chemicals for inhalation toxicity potential. Since PFAS have strong surface-active properties, we hypothesized they m...

Environmental pollutants capable of interfering with the thyroid hormone (TH) system increasingly raise concern for both human and environmental health. Recently, resorcinol has received attention as a compound of concern due to its endocrine disrupting properties. It is a known ...

The Adverse Outcome Pathway (AOP) framework contributes to understanding of how specific and measurable biological perturbations cause adverse effects on human and environmental health. Recognizing the value of AOPs to support regulatory decisions around the world, the Organisati...

Here we present an updated version of the database, which includes an increased number of adverse outcomes and corresponding key events derived from updated feeds from the AOP-Wiki (https://aopwiki.org/), updated chemical, gene, tissue, disease information, as well as population-...

There is a need for more efficient use of existing data to characterize human toxicological response data for environmental chemicals of interest to the US Environmental Protection Agency (EPA). The Adverse Outcome Pathway (AOP) framework helps to organize existing mechanistic in...

Presentation for the Environmental Health Language Collaborative (EHLC) Adverse Outcome Pathway (AOP) Standards workshop, held virtually on June 4-5, 2025. The workshop will center on ways to improve the computability of Adverse Outcomes Pathways (AOPs) through a range of approac...

In 2017 the Wisconsin DNR reported observation of a high incidence of fish with fin erosion in Newton Creek, which originates near the site of the local oil refinery and flows approximately 2 miles through the city of Superior before discharging at the Hog Island Inlet of the Sup...

An adverse outcome pathway (AOP) is an analytical framework used to organize biomechanistic information linking molecular-level exposure events to downstream adverse outcomes, important for regulatory decision-making. The AOP-Wiki is a globally accessible user interface for the A...

Proteomic and behavioral alterations following developmental emamectin benzoate exposure in rats – effects in development and adulthood Emily M. Pitzer1, Tracey E. Beasley1, Garyn L. Jung1, Kathy L. McDaniel1, William T. Padgett1, Witold M. Winnik1, David W. Herr1 1Neurolog...

Background and Purpose: Lung surfactant (LS) critically impacts respiration by creating an air-liquid interface that reaches near-zero surface tension (ST) during compression. Inhibition of LS function is a molecular initiating event in an adverse outcome pathway resulting in dec...

Original submitted abstract for Symposium: Male reproductive impairments, such as hypospadias, cryptorchidism and reduced sperm counts, are relatively common and have reportedly been increasing in prevalence over the last several decades. These effects can be induced in laborator...

An Adverse Outcome Pathway (AOP) is a framework for organizing knowledge about the etiology of an adverse phenotypic outcome. AOPs include a Molecular Initiating Event (MIE) and downstream Key Events (KEs) leading to an adverse outcome. Completion of the sequence depends on Key E...

There is a need to develop quick and sensitive chemical screening workflows such as utilization of in vitro new approach methods (NAMs) to reduce the number of animals used and increase efficiency to make informed decisions before proceeding to in vivo testing for neurotoxicity (...

Phthalic acid esters (phthalates) are male reproductive toxicants that exert their most potent toxicity during a window of sensitivity in fetal development. In the fetal rat, exposure to phthalates reduces testosterone biosynthesis, alters the development of seminiferous cords, a...

Though estrogenic and androgenic contaminants have received extensive attention as endocrine disrupting and modulating chemicals causing water quality concerns, glucocorticoid agonism has been receiving increasing attention in aquatic systems. Of particular interest are synthetic...

The ECOTOXicology Knowledgebase (ECOTOX) has been locating and curating ecologically-relevant toxicity data for over 30 years and is now a nationally and internationally recognized source of single-chemical toxicity test results for aquatic and terrestrial organisms. Through deca...

The global regulatory landscape surrounding chemical safety is shifting away from animal testing and moving toward greater reliance on New Approach Methodologies (NAMs) including a rapid growth in molecular data and computational methods to achieve human and environmental protect...

No abstract required for this meeting.

No abstract for this meeting

The global regulatory landscape surrounding chemical safety is shifting away from animal testing and moving toward greater reliance on New Approach Methodologies (NAMs) including a rapid growth in molecular data and computational methods to achieve human and environmental protect...

Regulatory decisions surrounding chemical safety are based primarily, although not exclusively, on human and environmental protection. Historically, there has been a reliance on animal toxicity testing to inform hazard and risk assessment. Typically, mammalian data drive human he...

Viral protein interactions with host proteins in humans and other organisms are important for the transmission of SARS-CoV2. Understanding each step of the process by which host proteins interact with the viral proteins in severe acute respiratory syndrome coronavirus 2 (SARS-CoV...

Apis bee health has gained significant attention due to the increases in colony death and failure. Chemical stressors, such as neonicotinoid insecticides, along with non-chemical stressors contribute to impact on colonies. In addition to the concern surrounding Apis bee populatio...