EPA Science Inventory

Search Criteria:

Records with

  • Keyword = adverse outcome pathway.
  (Sorted by Fiscal Year)
Records 1 to 25 of 334

2017
Identification of vascular disruptor compounds by a tiered analysis in ebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
21st century tools to prioritize contaminants for monitoring and management (PRESENTATION)
The webinar focused on ways that ToxCast high throughput screening data and the adverse outcome pathway framework, under development in the CSS program, can be used to prioritize environmental contaminants for monitoring and management.
A catalog of putative adverse outcome pathways (AOPs) that will enhance the utility of ToxCast high throughput screening data for hazard identification, delivered via a putative AOP knowledgebase and a ToxCast assay annotation file that can be linked with the iCSS dashboard. (EXTRAMURAL DOCUMENT)
A number of putative AOPs for several distinct MIEs of thyroid disruption have been formulated for amphibian metamorphosis and fish swim bladder inflation. These have been entered into the AOP knowledgebase on the OECD WIKI.
A conceptual framework to support exposure science research and complete the source-to-outcome continuum for risk assessment (PRESENTATION)
While knowledge of exposure is fundamental to assessing and mitigating risks, exposure information has been costly and difficult to generate. Driven by major scientific advances in analytical methods, biomonitoring, computational tools, and a newly articulated vision for a great...
A tiered approach for integrating exposure and dosimetry with in vitro dose-response data in the modern risk assessment paradigm (PRESENTATION)
High-throughput (HT) risk screening approaches apply in vitro dose-response data to estimate potential health risks that arise from exposure to chemicals. However, much uncertainty is inherent in relating bioactivities observed in an in vitro system to the perturbations of biolog...
A tiered approach to evaluate an iodine recycling inhibition adverse outcome pathway (AOP) in amphibians (PRESENTATION)
The enzyme iodotyrosine deiodinase (dehalogenase, IYD) catalyzes iodide recycling and promotes iodide retention in thyroid follicular cells. Loss of function or chemical inhibition of IYD reduces thyroid hormone synthesis, which leads to insufficiency in tissues and subsequent ne...
Advancing the Adverse Outcome Pathway Framework - an International Horizon Scanning Approach (JOURNAL)
The ability of scientists to conduct whole organism toxicity tests to understand chemical safety has been significantly outpaced by the rapid synthesis of new chemicals. Therefore, to increase efficiencies in chemical risk assessment, scientists are turning to mechanistic-based ...
Advancing the adverse outcome pathway framework and its applications through a global horizon scanning exercise (PRESENTATION)
Regulatory agencies worldwide are confronted with the challenging task of assessing the risks of thousands of chemicals to protect both human health and the environment. Traditional toxicity testing largely relies on apical endpoints from whole animal studies, which, in addition...
Adverse Outcome Pathway (AOP) framework for embryonic vascular disruption and developmental defects (SOT) (PRESENTATION)
Vascular development commences with de novo assembly of a primary capillary plexus (vasculogenesis) followed by its expansion (angiogenesis) and maturation (angio-adaptation) into a hierarchical system of arteries and veins. These processes are tightly regulated by genetic signal...
Adverse Outcome Pathways – Organizing Toxicological Information to Improve Decision Making (JOURNAL)
The number of chemicals for which environmental regulatory decisions are required far exceeds the current capacity for toxicity testing. High throughput screening (HTS) commonly used for drug discovery has the potential to increase this capacity. The adverse outcome pathway (AOP)...
Adverse outcome pathways (AOPs) to enhance EDC screening and testing: Overview of recent activities and future efforts (PRESENTATION)
Screening and testing for endocrine active chemicals was mandated under 1996 amendments to the Safe Drinking Water Act and Food Quality Protection Act. Efficiencies can be gained in the endocrine disruptor screening program by using available biological and toxicological knowledg...
An "EAR" on environmental surveillance and monitoring: A case study on the use of exposure-activity ratios to prioritize sites, chemicals, and bioactivities of concern in Great Lakes waters (JOURNAL)
Current environmental monitoring approaches focus primarily on chemical occurrence. However, based on chemical concentration alone, it can be difficult to identify which compounds may be of toxicological concern for prioritization for further monitoring or management. This can be...
An Integrative data mining approach to identifying Adverse Outcome Pathway (AOP) Signatures (JOURNAL)
The Adverse Outcome Pathway (AOP) framework is a tool for making biological connections and summarizing key information across different levels of biological organization to connect biological perturbations at the molecular level to adverse outcomes for an individual or populatio...
Application of Adverse Outcome Pathways (AOPs) in Human Health and Ecotoxicology Capturing Divergent Consequences of Conserved Molecular Initiating Events via AOP Networks (Presentation) (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Application of High-Throughput In Vitro Assays for Risk-Based Chemical Safety Decisions of Environmental and Industrial Chemicals (SOT presentation) (PRESENTATION)
Multiple drivers shape the types of human-health assessments performed on chemicals by U.S. EPA resulting in chemical assessments are “fit-for-purpose” ranging from prioritization for further testing to full risk assessments. Layered on top of the diverse assessment needs are the...
Application of IATA - A case study in evaluating the global and local performance of a Bayesian Network model for Skin Sensitization (JOURNAL)
Since the publication of the Adverse Outcome Pathway (AOP) for skin sensitization, there have been many efforts to develop systematic approaches to integrate the information generated from different key events for decision making. The types of information characterizing key event...
Application of ToxCast to evaluate potential biological effects from organic contaminants in Great Lakes tributaries (PRESENTATION)
With the development of “high throughput” in-vitro biological assays, screening-level information on potential adverse biological effects is available for a rapidly increasing number of chemicals. The U.S. EPA ToxCast program has now evaluated several thousand chemica...
Application of adverse outcome pathway-based tools to ambient water quality criteria development (PRESENTATION)
Increasing numbers and diversity of chemical contaminants are being detected in ambient surface waters. States, regions, and communities across the US are faced with the issue of understanding which chemicals may warrant concern and at what concentrations. Integrating new scienti...
Application of adverse outcome pathways (AOPs) in human health and ecotoxicology capturing divergent consequences of conserved molecular initiating events via AOP networks (PRESENTATION)
The adverse outcome pathway (AOP) framework was developed to help organize and disseminate existing knowledge concerning the means through which specific perturbations of biological pathways can lead to adverse outcomes considered relevant to risk-based regulatory decision-making...
Application of the Attagene FACTORIAL™ assay to characterization of surface waters from a nationwide assessment of streams (PRESENTATION)
Bioassays can be used to evaluate the integrated effects of complex mixtures from both known and unidentified contaminants present in environmental samples. However, such bio-monitoring approaches have typically focused only on one or a few pathways (e.g. estrogen receptor, andro...
Applications of AOPs to ecotoxicology (PRESENTATION)
Toxicologists conducting safety assessments for either human or ecological health are responsible for generating data for possible adverse effects of a rapidly increasing number of substances. For example, the Registration, Evaluation, Authorisation and Restriction of Chemicals (...
Applying 21st century tools to watersheds of the western US: Sites, bioactivities, and chemicals of concern (PRESENTATION)
The webinar focused on ways that ToxCast high throughput screening data and the adverse outcome pathway framework, under development in the CSS program, can be used to prioritize environmental contaminants for monitoring and management.
Applying Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks to link toxicity testing data to exposure-relevant and biologically-relevant responses (PRESENTATION)
Hazard assessment for nanomaterials often involves applying in vitro dose-response data to estimate potential health risks that arise from exposure to products that contain nanomaterials. However, much uncertainty is inherent in relating bioactivities observed in an in vitro syst...
Bioaccumulation and toxicity of the flame retardant TBPH or the polychlorinated biphenyl PCB153 during dietary exposure in mummichog (Fundulus heteroclitus) (PRESENTATION)
The use of polybrominated diphenyl ethers as flame retardants in consumer products has been scrutinized increasingly due to their environmental persistence and potential toxicity; however, alternative replacement flame retardants may have similar drawbacks. The alternative bromin...
Bringing the fathead minnow (Pimephales promelas) into the genomic era (PRESENTATION)
The fathead minnow (Pimephales promelas) is a well-established ecotoxicological model organism that has been widely used for regulatory ecotoxicity testing and research for over a half century. Throughout this time, a lot of knowledge has been gained about the fathead minnow&rsqu...