Science Inventory

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Records with

  • Keyword = adverse outcome pathway.
  (Sorted by Fiscal Year)
Records 1 to 25 of 477

2018
Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells (JOURNAL)
The large number of diverse chemicals in production or in the environment has motivated medium to high throughput in vitro or small animal approaches to efficiently profile chemical-biological interactions and to utilize this information to assess risks of chemical exposures on h...
.Network analytics for adverse outcome pathways (PRESENTATION)
Adverse Outcome Pathways (AOPs) organize toxicological knowledge from the molecular level up to the population level, providing evidence-based causal linkages at each step. The AOPWiki serves as a repository of AOPs. With the international adoption of the AOP framework, the AOPw...
3D-QSAR Study of Steroidal and Azaheterocyclic Human Aromatase Inhibitors using Quantitative Profile of Protein-Ligand Interactions (JOURNAL)
Aromatase is a member of the cytochrome P450 superfamily responsible for a key step in the biosynthesis of estrogens. As estrogens are involved in the control of important reproduction-related processes, including sexual differentiation and maturation, aromatase is a potential ta...
A Case Study Application of the Aggregate Exposure Pathway (AEP) and Adverse Outcome Pathway (AOP) Frameworks to Facilitate the Integration of Human Health and Ecological End Points for Cumulative Risk Assessment (CRA) (JOURNAL)
Cumulative risk assessment (CRA) methods promote the use of a conceptual site model (CSM) to apportion exposures and integrate risk from multiple stressors. While CSMs may encompass multiple species, evaluating end points across taxa can be challenging due to data availability an...
A Comprehensive Framework for Evaluation of Engineered Nanomaterials- NS2017 (PRESENTATION)
Engineered nanomaterials (ENM) are a fundamental and growing component of the global economy, and are projected to reach an annual economic impact in the hundreds of billions of dollars. Currently, their growing use far outpaces our ability to evaluate potential for adverse impac...
A Network of AOPs for reduced thyroid hormone synthesis derived from inhibition of Thyroperoxidase - A common Molecular Initiating Event Leading to Species-Specific Indices of Adversity. (EXTRAMURAL DOCUMENT)
This collection of 3 AOPs describe varying outcomes of adversity dependent upon species in response to inhibition of thyroperoxidase (TPO) during development. Chemical inhibition of TPO, the molecular-initiating event (MIE), results in decreased thyroid hormone (TH) synthesis, a...
A Quantitative Adverse Outcome Pathway for Ecotoxicity: Modeling Reproductive Adversity in Fathead Minnows (PRESENTATION)
A quantitative adverse outcome pathway (qAOP) consists of interrelated computational models that together describe the mechanistic biology linking a toxicant-induced, molecular-level initiating event (MIE) with an adverse outcome at the level of individuals or populations. A qAOP...
A case study to illustrate the utility of the Aggregate Exposure Pathway and Adverse Outcome Pathway frameworks for integrating human health and ecological data into cumulative risk assessment (PRESENTATION)
Cumulative risk assessment (CRA) methods, which evaluate the risk of multiple adverse outcomes (AOs) from multiple chemicals, promote the use of a conceptual site model (CSM) to integrate risk from relevant stressors. The Adverse Outcome Pathway (AOP) framework can inform these r...
A conceptual framework to advance exposure science research and complement the Adverse Outcome Pathway framework (PRESENTATION)
A tremendous amount of data on environmental stressors has been accumulated in exposure science, epidemiology, and toxicology, yet most of these data reside in different silos. The Adverse Outcome Pathway (AOP) framework was developed as an organizing principle for toxicological ...
A glucocorticoid signaling-related adverse outcome pathway network links inhaled pollutants with multiple adverse outcomes (PRESENTATION)
The Adverse Outcome Pathway (AOP) framework represents an ideal tool for integrating diverse data relating chemical exposures to adverse outcomes. Glucocorticoid signaling is tightly controlled and numerous adverse health outcomes have been associated with either elevation or sup...
A mechanistic framework for integrating chemical structure and high-throughput screening results to improve toxicity predictions (JOURNAL)
Adverse Outcome Pathways (AOPs) establish a connection between a molecular initiating event (MIE) and an adverse outcome. Detailed understanding of the MIE provides the ideal data for determining chemical properties required to elicit the MIE. This study utilized high-throughput ...
A method for CRISPR/Cas9 mutation of genes in fathead minnow (PRESENTATION)
Product Description: CRISPR/Cas9 is a system that can be used to disrupt a gene of interest in any animal. It allows us to study each gene’s role by observing changes in the animal when the gene isn’t functional. We worked out a method to use this technology in the f...
A novel in silico model for systematic prediction of developmental toxicity. (PRESENTATION)
Animal-based methods are the standard approach to assess developmental toxicity. Mechanism-based in vitro assays and in silico predictive tools are desired alternatives. We used 4 elements to develop a novel in silico predictive model: 1. Mouse Genome Informatics database to comp...
A reduced transcriptome approach to assess environmental toxicants using zebrafish embryo tests (JOURNAL)
This paper reports on the pilot testing of a new bioassay platform that monitors expression of 1600 genes in zebrafish embryos exposed to either single chemicals or complex water samples. The method provides a more cost effective, high throughput means to broadly evaluate the pot...
AOP Extended Ontology: A new approach to categorise AOP Key Events (PRESENTATION)
The Adverse Outcome Pathway Knowledge Base (AOP- KB, http://aop-kb.org) is a crowdsourcing multi-module platform aimed to support the collaborative development, sharing, and dissemination of AOP-related knowledge. The AOP- KB Wiki module provides a user-friendly interface for AOP...
AOP Wiki Version 2.0 (DATA)
Version 2.0 of the AOP-Wiki was released on December 4, 2016. This was a major upgrade and should provide a better user experience. It fixes a number of bugs with the previous version, provides a more streamlined user interface, and sets the stage for providing more programmatic...
AOP-DB Frontend: A user interface for the Adverse Outcome Pathways Database (PRESENTATION)
The EPA Adverse Outcome Pathway Database (AOP-DB) is a database resource that aggregates association relationships between AOPs, genes, chemicals, diseases, pathways, species orthology information, ontologies. The AOP-DB frontend is a simple yet powerful user interface in the for...
AOP-DB Frontend: A user interface for the Adverse Outcome Pathways Database. (PRESENTATION)
The EPA Adverse Outcome Pathway Database (AOP-DB) is a database resource that aggregates association relationships between AOPs, genes, chemicals, diseases, pathways, species orthology information, ontologies. The AOP-DB frontend is a simple yet powerful AOP-DB user interface in...
AOP-DB: A database resource for the exploration of Adverse Outcome Pathways through integrated association networks. (JOURNAL)
The Adverse Outcome Pathway (AOP) framework describes the progression of a toxicity pathway from molecular perturbation to population-level outcome in a series of measurable, mechanistic responses. The controlled, computer-readable vocabulary that defines an AOP has the ability t...
AOP-driven Predictive Models for Carcinogenicity: an exercise in interoperable data application. (PRESENTATION)
Traditional methods and data sources for risk assessment are resource-intensive, retrospective, and not a feasible approach to address the tremendous regulatory burden of unclassified chemicals. As a result, the adverse outcome pathway (AOP) concept was developed to facilitate a ...
AOP-informed assessment of endocrine disruption in freshwater crustaceans (PRESENTATION)
To date, most research focused on developing more efficient and cost effective methods to predict toxicity have focused on human biology. However, there is also a need for effective high throughput tools to predict toxicity to other species that perform critical ecosystem functio...
Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources (JOURNAL)
The adverse outcome pathway (AOP) concept links molecular perturbations with organism and population-level outcomes to support high-throughput toxicity testing. International efforts are underway to define AOPs and store the information supporting these AOPs in a central knowledg...
Acute and Subchronic Toxicity of Inhaled Toluene in Male Long-Evans Rats: Oxidative Stress Markers in Brain (JOURNAL)
The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute an...
Addressing species diversity in biotransformation: Variability in expressed transcripts of Phase I and II hepatic enzymes among fishes (PRESENTATION)
The ability of an organism to metabolize a pollutant is critical to understanding the risk the chemical poses to the organism. In the environment, fish are uniquely exposed to pollutants found in agricultural runoff and discharges from industry and wastewater treatment plants. M...
Advancing the Adverse Outcome Pathway Framework – An International Horizon Scanning Approach (PRESENTATION)
In 2007, the U.S. National Research Council laid out a vision and strategy for toxicity testing in the 21st century, which aspired to transform current testing approaches by making greater use of recent scientific advances in cell-based and computational methods. The adverse outc...