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  • Keyword = Chemical Safety.
  (Sorted by Fiscal Year)
Records 1 to 25 of 3798

Addressing Data Bias in Machine Learning for Hepatotoxicity Predictions Using Targeted Transcriptomics
(PRESENTATION) [Presented : Oct 14, 2021]
Animal-based toxicity testing is both costly and time-consuming, making it difficult to keep up with the ever-increasing number of potentially harmful chemicals in the environment. Computational techniques that employ high-throughput experimental data can be used to analyze chemi...
Application of Cell Painting, an Imaging-Based High Throughput Phenotypic Profiling Assay for Bioactivity Screening of Environmental Chemicals (SOT 2021)
(PRESENTATION) [Presented : Mar 25, 2021]
Cell Painting is an imaging-based high throughput phenotypic profiling (HTPP) assay that uses fluorescent probes to label a variety of organelles (e.g., nucleus, endoplasmic reticulum, Golgi, mitochondria) and measures a large number of features at the cellular level (e.g., inten...
Role of water chemistry on stability, aggregation, and dissolution of uncoated and carbon-coated copper nanoparticles
(JOURNAL) [Published : Aug 01, 2020]
Intentional or accidental release of copper nanoparticles (Cu-NPs) from consumer products during manufacturing, use, and end-of-life management could pose health and ecological risks. This paper presents a detailed study on the role of water chemistry on the fate of uncoated and ...
Advancing the accuracy of open chemical information with CAS Common Chemistry
(PRESENTATION) [Presented : Apr 30, 2021]
Open resources from authoritative sources are a key driver of open data quality. The recentrelaunch of CAS Common Chemistry, which expands the resource to include nearly 500,000 substances fromCAS REGISTRY® and offers this content for community use under a Creative Commons At...
The US-EPA CompTox Chemicals Dashboard to Support Mass Spectrometry
(PRESENTATION) [Presented : Feb 05, 2021]
Chemical safety decisions and management can be hindered by the lack of ready-access to the ever-expanding array of data, tools, and models that are relevant to the analyses. Even though many chemical safety resources are available, it may not be clear how the various sources of ...
Predicting Molecular Initiating Events from High Throughput Transcriptomic Screening using Machine Learning
(PRESENTATION) [Presented : Apr 30, 2021]
Background The advent of high-throughput transcriptomic screening technologies has resulted in a wealth of gene expression signatures associated with chemical perturbagens. One resource is the Library of Integrated Network-Based Cellular Signatures (LINCS) spanning ~20k chemical ...
High Throughput In Vitro Assays for Chemical Safety Evaluation
(PRESENTATION) [Presented : Mar 19, 2021]
In the EPA Center for Computational Toxicology and Exposure's research, we need to screen thousands of chemicals for potency and mechanism of action. We can now do this with high-throughput phenotypic profiling (HTPP), high-throughput transcriptomics (HTTr), and high-throughput s...
High-Throughput Transcriptomics (HTTr) for Chemical Safety Screening (GEMS Meeting May 2021)
(PRESENTATION) [Presented : May 24, 2021]
CCTE has developed an automated in vitro screening workflow that allows the profiling of transcriptional responses to multiple chemicals in multiple cell lines.  A pilot project in MCF-7 cells was recently published, but data has already been generated for over a thousand ch...
Experimental Variability and Uncertainty in the Context of New Approach Methodologies for Potential Use in Chemical Safety Evaluation
(PRESENTATION) [Presented : Jun 25, 2020]
New approach methodologies (NAMs), such as quantitative structure activity relationship (QSAR) models based on chemical structure information, are commonly used to predict hazard in the absence of experimental data. QSAR models are developed and validated using experimental (i.e....
Characterization of Novel Human Immortalized Thyroid Follicular Epithelial Cell Lines
(JOURNAL) [Published : Jun 16, 2021]
Introduction: Investigation of normal human thyroid function using in vitro culture systems is dependent on cells that recapitulate physiology of differentiated thyrocytes. Primary thyrocytes retain features of the native organ but have limited life span in culture...
Thresholds Derived from Common Measures in Rat Studies are Predictive of Liver Tumorigenic Chemicals
(JOURNAL) [Published : Oct 01, 2020]
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES study, 75 chemicals were examined across chemical-dose-t...
Influence of polymer additives on gas-phase emissions from 3D printer filaments
(JOURNAL) [Published : Sep 01, 2021]
A collection of six commercially available, 3D printer filaments were analyzed with respect to their gas-phase emissions, specifically volatile organic compounds (VOCs), during simulated fused deposition modeling (FDM). Filaments were chosen because they were advertised to contai...
High Throughput Toxicokinetic (HTTK) Modeling of Inhalation Exposures
(PRESENTATION) [Presented : Aug 20, 2020]
The inhalation route of chemical exposure is important for both occupational and general population exposures. Unfortunately, in vivo data describing chemical toxicokinetics (that is, absorption, distribution, metabolism, and excretion) are typically unavailable for the chemicals...
Collaborative Evaluation of In Silico Predictions for High Throughput Toxicokinetics (QSAR)
(PRESENTATION) [Presented : Jun 09, 2021]
Chemical hazard, exposure, and the shape of the dose-response curve are typically evaluated to predict potential human health risk. The dose-response curve and estimates of internal exposure (dose) depend upon chemical-specific toxicokinetics – the absorption, distribution,...
Case Study: Comparison of approaches for the exposure assessment of triphenyl phosphate, a semi-volatile flame retardant, used in an upholstered chair
(PRESENTATION) [Presented : Sep 02, 2021]
Semi-volatile organic compounds (SVOCs), when compared to volatile organic compounds (VOCs), tend to emit more slowly and steadily, and to sorb to surfaces, suspended particulates and settled dust. Exposure assessments of SVOCs require both measured data and modeling approaches t...
COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals
(JOURNAL) [Published : Aug 01, 2021]
The COSMOS Database (DB) was originally established to provide reliable data for cosmetics-related chemicals within the COSMOS Project funded as part of the SEURAT-1 Research Initiative. The database has subsequently been maintained and developed further into COSMOS Next Generati...
Transformation and Release of Micronized Cu used as a Wood Preservative in Treated-Wood in Wetland Soil
(JOURNAL) [Published : Oct 15, 2021]
Micronized Cu (µ-Cu) is used as a wood preservative, replacing toxic chromated copper arsenate (CCA). Micronized Cu is malachite [Cu2CO3(OH)2] that has been milled to micron/submicron particles, many with diameters less than 100 nm, and then mixed with quat or azole biocide...
Perspectives on the Use of High Throughput Profiling Assays in Next Generation Risk Assessment
(PRESENTATION) [Presented : Sep 02, 2021]
Recently, numerous scientific and regulatory organizations in the U.S. and abroad have proposed the use of data from New Approach Methodologies (NAMs) for supplementing and increasing the pace of chemical safety assessments as well as reducing the number of laboratory animals use...
AOP-DB: A Database Resource for the Exploration of Adverse Outcome Pathways Through Integrated Association Networks
(JOURNAL) [Published : Mar 15, 2018]
The Adverse Outcome Pathway (AOP) framework describes the progression of a toxicity pathway from molecular perturbation to population-level outcome in a series of measurable, mechanistic responses. The controlled, computer-readable vocabulary that defines an AOP has the ability t...
Aop-Db Frontend: A User Interface for the Adverse Outcome Pathways Database (2017)
(PRESENTATION) [Presented : Nov 07, 2017]
The EPA Adverse Outcome Pathway Database (AOP-DB) is a database resource that aggregates association relationships between AOPs, genes, chemicals, diseases, pathways, species orthology information, ontologies. The AOP-DB frontend is a simple yet powerful user interface in the for...
Development of a prioritization method for chemical-mediated effects on steroidogenesis using an integrated statistical analysis of high-throughput H295R data
(JOURNAL) [Published : Dec 01, 2019]
Synthesis of 11 steroid hormones in human adrenocortical carcinoma cells (H295R) was measured in a high-throughput steroidogenesis assay (HT-H295R) for 656 chemicals in concentration-response as part of the US Environmental Protection Agency’s ToxCast program. This work ext...
Silver Nanoparticle Interactions with Surfactant-Based Household Surface Cleaners
(JOURNAL) [Published : Jun 11, 2021]
Silver nanoparticles (AgNPs) are the most widely used engineered nanomaterials in consumer products, primarily due to their antimicrobial properties. This widespread usage has resulted in concerns regarding potential adverse environmental impacts and increased probability of huma...