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  • Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.
  (Sorted by Fiscal Year)
Records 51 to 75 of 7397

2024
In Vitro-In Vivo Extrapolation of Thyroid-Related Endpoints with Higher Throughput Pregnancy PBPK Modeling
(PRESENTATION) [Presented : May 01, 2024]
To cause developmental toxicity, chemical exposures must cause bioactive concentrations in key tissues during susceptible lifestages, including during early fetal development. Next generation chemical risk assessment (NGRA) aims to replace and enhance traditional toxicity testing...
Quantifying Multipollutant Health Impacts Using the Environmental Benefits Mapping and Analysis Program–Community Edition (BenMAP-CE): A Case Study in Atlanta, Georgia
(JOURNAL) [Published : Mar 06, 2024]
Background: Air pollution risk assessments do not generally quantify health impacts using multipollutant risk estimates, but instead use results from single-pollutant or copollutant models. Multipollutant epidemiological models account for pollutant interactions and joint effects...
A New Approach Methodology for the Prediction of Tumorigenesis (NCSOT 23)
(PRESENTATION) [Presented : Sep 14, 2023]
Current methods for cancer risk assessment are resource-intensive and not practical for thousands of untested chemicals in the environment. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression biomarkers and associat...
Analysis of the Developmental Toxicity Profile of Per- and Polyfluoroalkyl Substances (PFAS) Using a Larval Zebrafish Assay
(PRESENTATION) [Presented : Apr 16, 2024]
Per- and polyfluoroalkyl substances (PFAS) are compounds found in many consumer and industrial products with ubiquitous spread in environmental matrices. While there is evidence that some PFAS, notably perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), cause d...
Q&A: Particulate matter pollution and cardiovascular health
(JOURNAL) [Published : Oct 09, 2023]
Invited Question and Answer article for Nature Cardiovascular Research on Particulate Matter.Recent air-quality alerts in major cities due to the wildfires in Canada, Hawaii and Greece have put fine particulate matter (PM) pollution and consequent health issues into the spotlight...
Biological Interpretation Model for Developmental Neurotoxicity
(PRESENTATION) [Presented : Apr 10, 2024]
New approach methodologies (NAMs) are being evaluated for their utility to inform developmental neurotoxicity (DNT) hazard instead of using animals. This work compares predictive models for DNT using DNT NAMs data. The dataset comprised 200 chemicals screened in 17 DNT assays wit...
Comparison of a high-density microelectrode array (MEA) assay for neurotoxicity screening using a 3D human iPSC-derived brain organoid model versus a 2D rat cortical cell model
(PRESENTATION) [Presented : Apr 10, 2024]
The relationship between environmental chemical exposure and a spectrum of neurological diseases is well-established. However, unraveling the underlying mechanism between human exposure and toxic outcomes presents significant challenges. Evaluation of neurotoxicity potential usin...
OECD DNT expert group: mathematical models
(PRESENTATION) [Presented : Apr 11, 2024]
The meeting aims to 1) discuss progress towards updating the Initial Recommendations to an OECD guidance, 2) discuss the regulatory implementation of the current DNT-IVB and strategy to include/exclude additional assays, and 3) discuss complementary aspects of the guidance that a...
Characterization of signaling pathways in in vitro developmental neurotoxicity battery (TSfN)
(PRESENTATION) [Presented : Apr 26, 2024]
Neurite outgrowth is an important precursor to synapse formation and assays for neurite outgrowth are part of an in vitro battery (IVB) of assays for developmental neurotoxicity screening (DNT). This battery of assays evaluates chemical effects on key neurodevelopmental processes...
Evaluating two analysis methods for the microelectrode array network formation assay (TSfN)
(PRESENTATION) [Presented : Apr 26, 2024]
Background: In vitro new approach methods (NAMs) have been developed for evaluating developmental neurotoxicity (DNT) potential. One such DNT NAM, the Network Formation Assay (NFA), uses a twelve-day exposure model to measure neuronal network activity changes in primary rat corti...
Examples of How Data from in vitro Developmental Neurotoxicity Assays Are Being Used to Make Decisions About Chemicals
(PRESENTATION) [Presented : Sep 02, 2021]
Over the past decade, a concerted effort has been made to develop in vitro and alternative assays that detect compounds with the potential to cause developmental neurotoxicity. As a result, a battery of assays has been developed that is believed to be useful for decision-making r...
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data
(JOURNAL) [Published : Jan 30, 2024]
Background:  Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...
A Comparison of In Vitro Points of Departure with Human Blood Levels for Per- and Polyfluoroalkyl Substances (PFAS) (Toxics)
(JOURNAL) [Published : Apr 05, 2024]
Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, cancer, and other adverse healt...
Summary of Research on Airborne Tire Wear including 6PPD/6PPD-quinone- Tyre Emissions and Sustainability Conference: April 2024
(PRESENTATION) [Presented : Apr 25, 2024]
With the declining tailpipe emissions from the US and worldwide motor vehicle fleet, impacts of tire and brake wear are an increasingly important area of interest.  Recent research has shown the compound 6PPD used in tires as an anti-degradation chemical reacts with ozone to...
SOT_Developmental toxicity across a suite of structurally diverse per- and polyfluoroalkyl substances (PFAS) in mummichog (Atlantic killifish)
(PRESENTATION) [Presented : Mar 14, 2024]
Per- and polyfluoroalkyl substances (PFAS) are increasingly at the forefront of environmental concern. Despite their frequent detection in environmental media, the highly persistent nature of many PFAS, and growing evidence demonstrating adverse health effects in a variety of spe...
New approach methods for developmental neurotoxicity: a per- and polyfluoroalkyl substances (PFAS) case study
(PRESENTATION) [Presented : Mar 21, 2024]
Presentation presented to the 1st International Electronic Conference on Toxics (IECTO)Session E. Novel Methods in Toxicology Research
By-degree Health and Economic Impacts of Lyme Disease, Eastern and Midwestern United States
(JOURNAL) [Published : Mar 13, 2024]
Journal article submitted to EcoHealth - (Abstract) - Lyme disease (LD) is the most common vector-borne disease in the United States (U.S.). This paper assesses how climate change may influence LD incidence in the eastern and upper midwestern U.S., and the associated economic bur...
Methods to Identify Hazards in Produced Water
(PRESENTATION) [Presented : Apr 05, 2024]
This is a lecture to the Colorado Produced Water Consortium to review methods that are used by EPA to evaluate chemicals and mixtures.
Trimethylbenzenes - Encyclopedia of Toxicology chapter
(BOOK CHAPTER) [Published : Apr 14, 2014]
Trimethylbenzene (TMB; CAS 25551-13-7) is a commercially available mixture of three individual isomers: 1,2,4-, 1,2,3-, and 1,3,5-TMB. TMB isomers are produced during petroleum refining. TMB exposure in humans occurs primarily through inhalation, although ingestion of TMB isomers...
In vitro mobilization of polychlorinated biphenyls and pesticides sorbed to ingested soils and house dusts
(PRESENTATION) [Presented : Mar 14, 2024]
Background and PurposeSoil and dust are effective sorbents for many organic chemicals and are known to concentrate lipophilic, less volatile, environmental pollutants. For children’s risk assessment, this is important, primarily because children consume relatively large qua...
Career Day
(PRESENTATION) [Presented : Apr 12, 2024]
Career Day at East Cary Magnet Middle School
Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (Syngenta SOT 24)
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose:   Limitations to the in vivo developmental neurotoxicity (DNT) test includes high variability, low reproducibility, and unknown human relevance. Moreover, neuropathological assessments in the DNT guideline are challenging due to methodology, lack of mecha...
US experience for NAM Implementation for DNT
(PRESENTATION) [Presented : Apr 10, 2024]
Presentation to the 5th International Conference on Developmental Neurotoxicity Testing (DNT5) April 2024
Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways using Omics Approaches
(PRESENTATION) [Presented : Apr 10, 2024]
Development of in vitro new approach methodologies (NAMs) has been driven by the need for developmental neurotoxicity (DNT) hazard data on thousands of chemicals. The network formation assay (NFA) characterizes DNT hazard based on changes in network formation but provides no mech...
Identification of training set chemicals to demonstrate the transferability of the developmental neurotoxicity in vitro battery
(PRESENTATION) [Presented : Apr 10, 2024]
The developmental neurotoxicity (DNT) in vitro battery (IVB) is a group of new approach methods for evaluation of potential compound effects on fundamental neurodevelopmental processes. These assays were developed to enhance efficiency of chemical screening and prioritization rel...