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Keyword = children's health or children's environmental health or adolescence or adolescent or child or childhood or children or developmental or daycare or early life or epigenetic or fetal or in utero or infant or maternal or paternal or perinatal or postnatal or pregnancy or pregnant or prenatal or school or young adult.

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2024

The Urgency for Optimization and Harmonization of Thyroid Hormone Analyses and Their Interpretation in Developmental and Reproductive Toxicology Studies
(JOURNAL) [Published : Sep 04, 2018]

In recent years several OECD test guidelines have been updated and some will be updated shortly with the requirement to measure thyroid hormone levels in the blood of mammalian laboratory species. There is, however, an imperative need for clarification and guidance regarding the ...

Chapter Eight: Neurotoxicity of poly- and perfluoroalkyl substances (PFAS): Epidemiological and rodent studies of behavioral outcomes
(BOOK CHAPTER) [Published : Oct 27, 2023]

Poly- and perfluoroalkyl substances (PFAS) are a large class of halogenated organic compounds (HOCs, also called organohalogens) utilized in a variety of industrial applications. Despite their widespread use in bulk quantities, significant concerns have been raised regarding thei...

Chapter One: Perspective on Halogenated Organic Compounds
(BOOK CHAPTER) [Published : Oct 27, 2023]

During the past century, a vast number of organic chemicals have been manufactured and used in industrial, agricultural, public health, consumer products, and other applications. The widespread use in bulk quantities of halogenated organic chemicals (HOCs; also called as Organoha...

Chapter Seven: Neurochemical effects of Halogenated Organic Compounds: Possible adverse outcome pathways and structure-activity relationships
(BOOK CHAPTER) [Published : Oct 27, 2023]

Halogenated organic compounds (HOCs) are long-lived toxic compounds and are of major concern for ecosystem and health. The use and manufacture of several HOCs is banned or phased out in most countries, but some HOCs are still being used in several countries. The levels of certain...

Innovative Approaches to Assessing Thyroid Disruption: The 3D Human Thyroid Microtissue Model
(PRESENTATION) [Presented : May 09, 2024]

In this LifeNet Health webinar, Dr. Deisenroth introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. He will discuss the US EPA Endocrine Disruptor Screening Program’...

OPFR Prioritization Using the Developmental Neurotoxicity In Vitro Test Battery: An Update to OECD IATA Case Study
(PRESENTATION) [Presented : Mar 14, 2024]

Background and Purpose Organophosphorus flame retardants (OPFRs) are abundant and persistent in the environment due to their extensive use in industrial processes and products. In vivo and in vitro studies suggest that OPFRs may cause adverse health effects. Additionally, their s...

Reproductive and developmental toxicity of solvents and gases
(BOOK CHAPTER) [Published : Feb 18, 2022]

This chapter is focused on the reproductive and developmental toxicity of selected environmentally relevant volatile solvents and gasses to which inhalation is a primary route of exposure in humans. Limited data are available regarding the human reproductive and developmental tox...

Peer Review of Report Modeling the Relationship Between Lead in Drinking Water and Blood Lead Levels in Children
(ASSESSMENT DOCUMENT) [Published : Oct 25, 2017]

EPA is peer reviewing the Agency’s report modeling the relationship between lead in drinking water and blood lead levels in children utilizing the Integrated Exposure Uptake Biokinetic (IEUBK) model. The report being peer reviewed may be used to inform the derivation of a concent...

Thyroid Hormone System Adverse Outcome Pathways and Developmental Neurotoxicity
(PRESENTATION) [Presented : Mar 13, 2024]

The Adverse Outcome Pathway (AOP) framework has been adopted as means to assemble, organize, and integrate all available biological information to support sound regulatory decision making. Environmental chemicals can interfere with the thyroid system at numerous sites, and these ...

Investigating effects and mechanistic pathways of perfluoroalkyl substance (PFAS) toxicity in developing mummichog (Atlantic killifish) using multi-omics
(PRESENTATION) [Presented : May 29, 2024]

Per- and polyfluoroalkyl substances (PFAS) are widespread, persistent chemicals associated with adverse health effects. However, mechanistic pathways underlying toxicity and hazards to wildlife, particularly estuarine and marine fish, are not fully characterized. We investigated ...

Extracellular MicroRNAs as Putative Biomarkers of Air Pollution Exposure
(BOOK CHAPTER) [Published : May 04, 2022]

Air pollution is a global environmental and public health issue. Exposure to air pollution is associated with elevated risk of morbidity and mortality from respiratory, cardiovascular, and neurological diseases. Following exposure to air pollution, the lung and other organ system...

Cyanobacterial blooms, iron, and environmental pollutants
(JOURNAL) [Published : Nov 01, 2023]

Iron determines the abundance and diversity of life and controls primary production in numerous aqueous environments. Over the past decades, the availability of this metal in natural waters has decreased. Iron deficiency can apply a selective pressure on microbial aquatic communi...

(Non)targeted Chemical Analysis and Risk Assessment of Organic Contaminants in Darkibor Kale Grown at Rural and Urban Farms
(JOURNAL) [Published : Feb 27, 2024]

This study investigated the presence and human hazards associated with pesticides and other anthropogenic chemicals identified in kale grown in urban and rural environments. Pesticides and related compounds (i.e., surfactants and metabolites) in kale samples were evaluated using ...

A systematic analysis of read-across within REACH registration dossiers
(JOURNAL) [Published : Mar 08, 2024]

Read-across is a well-established data-gap filling technique used within analogue or category approaches. Acceptance remains an issue, mainly due to the difficulties of addressing residual uncertainties associated with a read-across prediction and because assessments are expert-d...

In vivo laboratory studies of PFAS mixture effects on maternal, fetal, and neonatal health - Georgetown CPAC
(PRESENTATION) [Presented : Mar 08, 2024]

This Subproduct is a slide deck for an invited presentation at the Georgetown University Center for PFAS and Cancer (CPAC) Joint Virtual Symposium.  Slide deck presents the results of our group's PFAS developmental toxicity mixture studies.  This work demonstrates the d...

Traditional vs. Novel: Using Alternative Analysis Methods to Identify Negative Control Chemicals in Larval Zebrafish Behavior Assays (CSETAC 2024)
(PRESENTATION) [Presented : Apr 16, 2024]

Identifying reliable positive and negative control compounds is integral to determining the sensitivity and specificity of chemical assays. Our laboratory screens chemicals for developmental neurotoxicity potential using assays that assess larval zebrafish locomotor behavior in r...

TSCA Work Plan Chemical Risk Assessment: 1-Bromopropane
(ASSESSMENT DOCUMENT)

1-Bromopropane (CASRN 106-94-5): or 1-BP is a volatile organic chemical that is considered moderately persistent in the environment but does not have the potential to bioaccumulate in fish or other animals. The majority of the 1-BP production volume (~ 47%) is used as a vapor deg...

Effects-based tools to support water reuse in protein processing facilities
(PRESENTATION) [Presented : May 15, 2024]

Protein processing operations utilize large volumes of water for hair/hide/feather removal, carcass washing, chilling, trimming and cutting, cooking, cleaning and sanitation, etc. The generated wastewater is typically treated onsite and discharged to municipal wastewater treatmen...

The Impact of Biomass Smoke Exposure during Sperm Maturation on the Health of the Father and Their Offspring
(PRESENTATION) [Presented : May 22, 2024]

Presentation for PIC 2024 meeting 74% of U.S. firefighters are reproductive age (20 – 49 y.o.; 2019) • 92% of U.S. firefighters are male (2019) • A decrease from 99% in the 1980s (Perroni et al. 2021, PLoS One) • Male reproductive tract may be particularly se...

Detection of anatoxins in human urine by liquid chromatography triple quadrupole mass spectrometry and ELISA
(JOURNAL) [Published : Mar 01, 2024]

Harmful cyanobacterial blooms are becoming more common and persistent around the world. When in bloom, various cyanobacterial strains can produce anatoxins in high concentrations, which, unlike other cyanobacterial toxins, may be present in clear water. Potential human and animal...

Peer Review for EPA’s Proposed Approaches to Inform the Derivation of a Maximum Contaminant Level Goal for Perchlorate in Drinking Water
(PUBLISHED REPORT) [Published : Mar 29, 2018]

EPA is developing approaches to inform the derivation of a Maximum Contaminant Level Goal (MCLG) for perchlorate in drinking water under the Safe Drinking Water Act. EPA previously conducted an independent, external, scientific peer review of the draft biologically-based dose-res...

Peer Review for EPA’s Biologically Based Dose-Response (BBDR) Model for Perchlorate
(CRITERIA DOCUMENT) [Published : Mar 29, 2017]

EPA is developing a regulation for perchlorate in drinking water. As part the regulatory process EPA must develop a Maximum Contaminant Level Goal (MCLG). FDA and EPA scientists developed a biologically based dose-response (BBDR) model to assist in deriving the MCLG. This mode...

Screening Pesticides for Estrogenic and (anti)Androgenic Activity in Support of Endocrine Disruptor Screening Program (EDSP) Revival
(PRESENTATION) [Presented : Apr 15, 2024]

EPA’s Endocrine Disruptor Screening Program (EDSP) was established in 1998 to identify chemicals that disrupt human endocrine system signaling. EDSP has the potential to support the regulation of pesticides under FIFRA, the Federal Insecticide, Fungicide, and Rodenticide Ac...

An improved multicellular human organoid model for the study of chemical effects on palatal fusion
(JOURNAL) [Published : Oct 01, 2023]

Background:  Tissue fusion is a mechanism involved in the development of the heart, iris, genital tubercle, neural tube, and palate during embryogenesis. Failed fusion of the palatal shelves could result in cleft palate (CP), a common birth defect. Organotypic models co...

Gut metabolic changes during pregnancy reveal the importance of gastrointestinal region in sample collection
(JOURNAL) [Published : Mar 09, 2024]

Introduction: Studies of gastrointestinal physiology and the gut microbiome often consider the influence of intestinal region on experimental endpoints. However, this same consideration is not often applied to the gut metabolome. Understanding the contribution of gut regionality...