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There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field.

This talk is intended to update the progress of OECD method development for non-mammalian assays for endocrine-disrupting chemicals.

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field.

Knowledge of endocrine control of the complex larval developmental processes in insects (metamorphosis) has led to the introduction of insect hormones and their analogues as insecticides known as insect growth regulators (IGRs) with the largest group being juvenile hormone analog...

Japanese medaka (Oryzias latipes) have been developed as a model species to compare the effects of endocrine active chemicals at critical life-stage periods of hormonal sensitivity, specifically as reproductively active adults, during the developmental period of differentiation, ...

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

Many anthropogenic chemicals that are found in the environment act through estrogen receptors. Binding of xenobiotics to estrogen receptors could negatively impact an animal by disrupting the expression of gene products and proteins at critical times during development and reprod...

Adult female Lepidophthalmus louisianensis, Palaemonetes pugio, Rhithropanopeus harrisii, Mysidopsis bahia, and Uca panacea were collected from estuarine localities in Santa Rosa Sound, Gulf Breeze, FL during late spring and summer of 1999. Mature ovaries were dissected and homog...

There is no abstract available for this product. If further information is requested, please refer to the bibliographic citation and contact the person listed under Contact field.

The perspectives, information and conclusions conveyed in research project abstracts, progress reports, final reports, journal abstracts and journal publications convey the viewpoints of the principal investigator and may not represent the views and policies of ORD and EPA. Concl...

ORD's research program in Computational Toxicology (CompTox) will enable EPA Program Offices and other regulators to prioritize and reduce toxicity-testing requirements for potentially hazardous chemicals. The CompTox program defines the "toxicity process" as follows : 1) a stre...

The US Environmental Protection Agency&rsquo;s endocrine disruptor screening program (EDSP) is tasked with assessing thousands of chemicals for their potential to adversely impact human health and the environment through perturbation of endocrine pathways. Traditionally, chemical...

This is a short presentation for the US EPA / Japan Ministry of the Environment 14th Bilateral Meeting on Endocrine Disruption Test Methods Development June 2021.

As part of "Ongoing EDSP Directions & Activities" I will present CSS research on high throughput toxicokinetics, including in vitro data and models to allow rapid determination of the real world doses that may cause endocrine disruption.

A presentation at the U.S. Environmental Protection Agency – Japan Ministry of the Environment 16th Bilateral Meeting on Endocrine Disruption Test Methods Development. The topic covers EPA activities related to New Approach Methods for endocrine disruption hazard screening. 

Binding affinity between chemicals and the estrogen receptor (ER) serves as an indicator of the potential to cause endocrine disruption through this receptor-mediated endocrine pathway. Estimating ER binding affinity is, therefore, one strategic approach to reducing the costs of ...

poster presentation at a scientific meeeting

To better understand endocrine disruption, the US Environmental Protection Agency's (USEPA) Endocrine Disruptor&nbsp;Screening Program (EDSP) utilizes a two-tiered approach to investigate the potential of a chemical to interact with the estrogen, androgen, or thyroid systems. As&...

In order to detect environmental chemicals that pose a risk of endocrine disruption, high-throughput screening (HTS) tests capable of testing thousands of environmental chemicals are needed. Alteration of estrogen signaling has been implicated in a variety of adverse health effec...

The occurrence of endocrine disrupting chemicals (EDCs) in concentrated animal feed operation (CAFO) waste, and the potential effects of these chemicals on aquatic ecosystems have been of recent concern, especially in large agricultural regions. Currently, little is known concer...

Androgen receptor (AR) antagonism is a mechanism of endocrine disruption by environmental chemicals that is associated with a number of adverse effects including reproductive organ cancers and abnormalities. To identify chemicals that may act as AR antagonists, quantitative high-...

Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study we characterized a gene expression biomarker that was found to be an accurate predictor of ER&amp;alpha; modulation in chemically-treated human breas...

Per- and polyfluroalkyl substances (PFAS) are a large group of chemicals of concern based on their potential persistence, bioaccumulation, and toxicity. A tiered approach to screening and testing using new approach methodologies has been proposed as one of the few tractable appro...

Organohalogen compounds are global environmental pollutants. They are highly persistent, bioaccumulative, and cause adverse effects in humans and wildlife. Because of the widespread use of these organohalogens in household items and consumer products, indoor contamination may be ...

Screening technologies have been developed to identify xenobiotic chemicals that bind nuclear receptors and thus have potential for adverse health effects through disruption of endocrine function. However, the focus has been on human receptors despite environmental exposure to a ...