Office of Research and Development Publications

<< Previous

Next >>

N/A

N/A

N/A

Identifying reliable positive and negative control compounds is integral to determining the sensitivity and specificity of chemical assays. Our laboratory screens chemicals for developmental neurotoxicity potential using assays that assess larval zebrafish locomotor behavior in r...

The Road From Animal Models to New Approach Methods for Protecting Human and Animal Health &nbsp; Barbara L. F. Kaplan1, Alan M. Hoberman2, William Slikker Jr3, Mary Alice Smith4, Emanuela Corsini5, Thomas B. Knudsen6, M. Sue Marty7, Sonya K. Sobrian8, Suzanne C. Fitzpatrick9, Ma...

The Gulf of Mexico receives inputs from numerous tributaries that discharge natural organic matter (NOM) and other natural photosensitizers to its coastal beaches. Much of this NOM is colored dissolved organic matter (CDOM) which affects photoreactions of contaminants by light at...

The OECD Omics Reporting Framework (OORF) was developed to facilitate the regulatory use of omics data from laboratory-based toxicology studies, which is achieved by means of (i) increasing transparency and reproducibility, and (ii) supporting standardization and harmonization. T...

The US EPA uses exposure and toxicity information and risk assessments to protect human health and the environment from known hazards. However, some of the chemicals we are exposed to are unknown, undetected, and unregulated. Discovering the identity of unknown chemicals with mas...

N/A

Terrestrial organisms and ecosystems are being exposed to new and rapidly changing combinations of solar UV radiation and other environmental factors because of ongoing changes in stratospheric ozone and climate. In this Quadrennial Assessment, we examine the interactive effects ...

N/A

This is a lecture presentation to public health students in the Gilling School of Public Pealth at University of North Carolina at Chapel Hill.

N/A

On September 1, 2020, EPA published the final regulation, Use of Lead Free Pipes, Fittings, Fixtures, Solder, and Flux for Drinking Water. EPA made&nbsp; the conforming changes to existing regulations based on the Reduction&nbsp; of Lead in Drinking Water Act of 2011 and the Comm...

Lead can enter drinking water when service pipes that contain lead corrode, especially where the water has high acidity or low mineral content that corrodes pipes and fixtures. Homes may also have internal plumbing materials containing lead. To reduce exposure to lead in drinking...

Histone deacetylase inhibitors (HDACi) are epigenotoxicants that disrupt gene expression by modulating histone acetylation. We developed a transcriptomic biomarker of HDACi in human TK6 cells to address the limitations in tools available for identifying HDACi in chemical screenin...

Lead service lines (LSL) represent the greatest source of lead (Pb) in drinking water. Identifying LSLs can be challenging, and recent service line (SL) material surveys in Michigan, Illinois, Wisconsin and Indiana found that an average 16% of SLs in these states are unknown and ...

Poly- and perfluoroalkyl substances (PFAS) are oxidatively recalcitrant organic synthetic compounds. PFAS are an exceptional group of chemicals that have significant physical characteristics due to the presence of electronegative fluorine. PFAS persists in the environment, bioacc...

Background and Purpose: Time series data for environmentally relevant chemicals in body fluids and tissues after an exposure is rarely made available despite their importance for risk assessment. Further, access to in vivo data is crucial for chemical safety evaluation estimate...

The U.S. Environmental Protection Agency and Sandia National Laboratories have developed the Water Network Tool for Resilience (WNTR) to quantify resilience of drinking water distribution systems. WNTR is a Python package designed to simulate disaster scenarios and analyze impact...

Legionella pneumophila (Lp) is an opportunistic pathogen that causes respiratory infections primarily through inhalation of contaminated aerosols. Lp can colonize premise plumbing systems due to favorable growth conditions found within those environments (e.g. lower disinfectant ...

A key part of the problem formulation phase of environmental assessment is the development of conceptual model diagrams. These diagrams, which explicitly illustrate hypothesized pathways between sources, stressors, and responses relevant to the focal issue, are used in scoping an...

N/A

N/A

N/A