Science Inventory

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The in vivo functions of the bronchial epithelium can be recapitulated in vitro through the differentiation of primary human bronchial epithelial cells (pHBEC) under air-liquid interface (ALI) culture conditions.&nbsp; pHBEC ALI models have rapidly gained popularity for in vitro ...

From the paper: Endoderm gives rise to the gut tube in the early embryo. We di&iquest;erentiated human induced pluripotent stem cells (hiPSCs) to embryonic endoderm to identify a &ldquo;tipping point&rdquo; at which the developing system did not recover from perturbations caused ...

The fundamental unit in developmental biology is &lsquo;the cell&rsquo;, each with its own unique history (lineage) and environment (microphysiology). NexGen sequencing (RNA-seq) averages the transcriptome across a composite system but scRNAseq can now map individual cell lineage...

Assessing developmental toxicity during pregnancy has a critical role in setting health and environmental policy. In vitro assays and in silico models that reflect key aspects of embryo-fetal development will be indispensable for NAM-based detection of developmental hazard potent...

Introduction:&nbsp;Investigation of normal human thyroid function using&nbsp;in vitro&nbsp;culture systems is dependent on cells that recapitulate physiology of differentiated thyrocytes. Primary thyrocytes retain features of the native organ but have limited life span in culture...

No formal abstract; however, the topic will cover: (i) what synthetic models of human development (both computational and organoids) bring to future of DART testing; (ii) how smart must these models be (A.I.) to support decision making in the animal free (3Rs) zone; (iii) best pr...

High-throughput in vitro assays offer a promising alternative to pregnant animal studies for assessing developmental toxicity of chemicals. Varying cells used in high-throughput screening assays have unique properties of self-renewal, pluripotency, and self-organization which hel...

Global efforts are underway to transition toxicological risk assessment away from vertebrate animal models, as exemplified by the announcement from the U.S. EPA administrator announcing their intent to virtually eliminate use or funding of vertebrate animal research within 15 yea...

Focus of this lecture is on the predictive power of computational models and computer simulation for human relevant pathways underlying prenatal developmental toxicity, with an eye toward future goals of reduction-refinement-replacement of animal testing.