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Per- and polyfluoroalkyl substances (PFAS) are long-lasting environmental contaminants with known adverse impacts on fish and other taxa. However, understanding of their impacts on coastal environments, including the effect of chemical structure on toxicity in estuarine and marin...

This is a presentation abstract for proposed session, ID 141, Advances in New Approach Methods for Thyroid Toxicity Testing, for the SOT 2024 Annual Meeting.  Abstract: There is significant regulatory need to evaluate chemicals that may disrupt the thyroid endocrine system. ...

Background and Purpose: A virtual embryo may be conceptualized as a compendium of computational systems models that integrate biological systems information with chemical specific information to make predictions about developmental toxicity in a digital twin.  A challenge to...

Differentiated primary human bronchial epithelial cell (dpHBEC) cultures grown under air-liquid interface (ALI) conditions exhibit key features of the human respiratory tract and are thus critical for respiratory research as well as efficacy and toxicity testing of...

Presentation to Symposium in honor of Aldert Piersma’s Retirement RIVM Nov 2023

Scientific and practical needs exist for a different way to predict human developmental toxicity with less reliance on animal testing. The term New Approach Methods (NAMs) refers to any technology, methodology, approach, or combination thereof that can be used to provide informat...

Embryogenesis progresses from the fusion of the egg and sperm through many critical processes to establish the embryo proper. This lecture will describe and discuss those processes. Fusion of the sperm and egg establishes the one cell zygote. Continued cellular division, initiati...

Background:  Tissue fusion is a mechanism involved in the development of the heart, iris, genital tubercle, neural tube, and palate during embryogenesis. Failed fusion of the palatal shelves could result in cleft palate (CP), a common birth defect. Organotypic models co...

A presentation at the U.S. Environmental Protection Agency – Japan Ministry of the Environment 16th Bilateral Meeting on Endocrine Disruption Test Methods Development. The topic covers EPA activities related to New Approach Methods for endocrine disruption hazard screening. 

Human in vitro models of the developing brain are important for studying neurodevelopment and the potential developmental neurotoxicity (DNT) of environmental and pharmacological compounds. Exposure to these compounds during neurodevelopment can potentially cause adverse effects ...

Developmental hazard evaluation is an important part of assessing chemical risks during pregnancy. While New Approach Methods (NAM) based on in vitro chemical effects data offer alternatives to pregnant animal testing, adverse fetal outcomes in vivo result from complex interactio...

Cellular agent-based models (ABMs) are a novel approach to: (i) visualize cellular trajectories; (ii) map toxicodynamics; and (iii) predict adverse phenotype (cybermorphs). In silico reconstitution of a self-organizing embryo from in vitro data (eg, embryogeny) remains a challeng...

Thyroid hormone system disruption (THSD) negatively affects multiple developmental processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in)activating thyroid hormones (THs), leads to impaired swim bladder inflation. Until now, the underlying me...

Palatogenesis is the multistage process by which the oral palate is formed. The final event, fusion of the palatal shelves and disintegration of the epithelial seam, is of particular interest as a point of failure which leads to cleft palate. Key limitations of animal models for ...

This presentation will convey the importance of three domains of knowledge, education and computational intelligence as applied to birth defects. It is an Awards lecture that honors the legacy of Narsingh Agnish who initiated the annual CE course for the Society for Birth Defects...

Per- and polyfluoroalkyl substances (PFAS) are a ubiquitously detected chemical class that poses significant environmental health concerns. Perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS) are persistent in the environment and associated with adverse...

Altered maternal thyroid hormones present an increased risk for child neurodevelopmental impairment, thus evaluating the potential impact of chemical exposures on thyroid hormone imbalance is of key regulatory concern. Thyroid new approach methods (NAMs) are being developed and a...

New Approach Methods (NAMs) refers to 21st-C testing strategies that rely on in vitro data and in silico models to predict human toxicity with less reliance on animal testing. Complex NAMs that accurately predict the potential for human developmental toxicity are needed to succee...

Per- and polyfluoroalkyl substances (PFAS) are a ubiquitously detected chemical class that poses significant environmental health concerns. Perfluorohexane sulfonic acid (PFHxS) and perfluorooctane sulfonic acid (PFOS) are highly persistent in the environment and are associated w...

Previous screening of the ToxCast chemical library in a pluripotent H9 human stem cell (hPSC) assay predicted developmental toxicity with a balanced accuracy 78-84% for well-curated reference compounds [Zurlinden et al. 2020]. Since the molecular biology of hPSCs in culture most ...

There is significant regulatory need to identify and evaluate chemicals that may disrupt the thyroid endocrine system. Thyroid new approach methods (NAMs) are being developed and applied to increase data coverage across the ToxCast/Tox21 chemical inventories using a tiered testin...

The Frank R. Lautenberg Chemical Safety for the 21st Century Act mandates the US EPA develop new approach methods to detect chemical risks to susceptible populations, including pregnant women, that reduce reliance on the use of vertebrate animals in chemical testing. The DevTox-G...

Wood smoke particulate (WSP) exposure causes respiratory disease including asthma, COPD, infections, and cancer.  The number of individuals exposed to WSP is increasing due to climate change and increased development at wildland urban interfaces, yet our knowledge of the cel...

There is significant regulatory need to identify and evaluate chemicals that may disrupt the thyroid endocrine system. Thyroid new approach methods (NAMs) are being developed and applied to increase data coverage across the ToxCast/Tox21 chemical inventories using a tiered testin...

The last two decades have seen a marked increase in concern over the effects of PFAS on humans and wildlife.  PFAS, or polyfluoralkyl substances, often called “the forever chemicals,” are persistent contaminants that enter the environment from a variety of source...