Science Inventory

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User Guide to describe the complete functionality of the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Version 3.0 online tool. The US Environmental Protection Agency Sequence Alignment to Predict Across Species Susceptibility tool (SeqAPASS; https://seqa...

This document represents an internationally reviewed and endorsed &ldquo;how to&rdquo; guide for the development of adverse outcome pathways (AOPs) and evaluation of their weight of evidence. Adverse outcome pathway descriptions are used to capture and organize the biological und...

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) Strategy Document on Toxicokinetics (TK) outlines strategies to enable prediction of systemic toxicity by applying new approach methodologies (NAM). The central feature of the strategy focuses...

A methodology for developing remediation goals for sites with contaminated sediments is provided. The remediation goals are based upon the concentrations of chemicals in the sediment interstitial water measured using the passive sampling technique. The passive sampling technique ...

New technologies that utilize capillary-based immunoassays promise faster and more quantitative protein assessment compared to traditional immunoassays. However, similar to other antibody-based protein assays, optimization of capillary-based immunoassay parameters, such as protei...

The Markov chain nest productivity model, or MCnest, is a set of algorithms for integrating the results of avian toxicity tests with reproductive life-history data to project the relative magnitude of chemical effects on avian reproduction. The mathematical foundation of MCnest i...

The post-remediation scenario selected by USEPA was constructed in the LTFATE modeling system that was used to perform this modeling study as follows: a) The bathymetry in the NBH portion of the model domain was updated using the latest bathymetric survey provided by EPA; b) In t...

StatCharrms is a graphical user front-end for ease of use in analyzing data generated from OCSPP 890.2200, Medaka Extended One Generation Reproduction Test (MEOGRT) and OCSPP 890.2300, Larval Amphibian Gonad Development Assay (LAGDA). The analyses StatCharrms is capable of perfor...

As a NAFTA-inspired multi-governmental initiative, experts from the US EPA (Office of Research and Development, Office of Pesticide Program, or OPP) and the PMRA (Pest Management Regulatory Agency) of Health Canada formed a working group to create a document that would serve as a...

EPA’s Sustainable and Healthy Communities (SHC) Research Program is developing methodologies, resources, and tools to assist community members and local decision makers in implementing policy choices that facilitate sustainable approaches in managing their resources affecting the...

RSCABS[3] (Rao-Scott adjusted Cochran-Armitage trend test By Slices) is a modification to the Rao-Scott[5] adjusted Cochran-Armitage trend test[1, 2] that allows for testing at each individual severity score often seen in histopathological data. The test was originally developed ...

Objectives of the water quality data analyses presented here are to examine the extent to which water quality could be sampled across US wetlands, to evaluate the various measurement endpoints obtained (e.g., variability, repeatability, information content), to present broad patt...

The measurement and characterization of nanomaterials in biological tissues is complicated by a number of factors including: the sensitivity of the assay to small sized particles or low concentrations of materials; the ability to distinguish different forms and transformations of...

No abstract nor impact statement - per Kelly-because we are not overall authors, but contributors to highly edited/joint pieces.

No abstract-per Kelly-because we are not overall authors, but contributors to highly edited/joint pieces.

A Regional Applied Research Effort project with EPA Region 10, ORD and USGS was initiated as a result of a baseline ecological risk assessment (BERA) problem formulation for the Upper Columbia River (UCR) site in northwest Washington. The UCR site is a 165-mile stretch of the Col...

This adverse outcome pathway (AOP) leverages existing knowledge in the open literature to describe the linkage between inhibition of acetylcholinesterase (AChE) and the subsequent mortality resulting from impacts at cholinergic receptors. The AOP takes a chemical category approa...

This Integrated Summary Report (ISR) summarizes, in a single document, the results from an international multi-laboratory validation study conducted for two in vitro estrogen receptor (ER) binding assays. These assays both use human recombinant estrogen receptor, alpha subtype (h...

SeqAPASS is a software application facilitates rapid and streamlined, yet transparent, comparisons of the similarity of toxicologically-significant molecular targets across species. The present application facilitates analysis of primary amino acid sequence similarity (including ...

This adverse outcome pathway details the linkage between binding and activation of androgen receptor as a nuclear transcription factor in females and the adverse effect of reduced cumulative fecundity in repeat-spawning fish species. Cumulative fecundity is the most apical endpoi...

This adverse outcome pathway details the linkage between inhibition of gonadal aromatase activity in females and the adverse effect of reduced cumulative fecundity in repeat-spawning fish species. Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Sh...

The Agency&rsquo;s Endocrine Disruptor Screening Program (EDSP) consists of two tiers. The first tier provides information regarding whether a chemical may have endocrine disruption properties. Tier 2 tests provide confirmation of ED effects and dose-response information to be us...

The Markov Chain nest productivity model, or MCnest, quantitatively estimates the effects of pesticides or other toxic chemicals on annual reproductive success of avian species (Bennett and Etterson 2013, Etterson and Bennett 2013). The Basic Version of MCnest was developed as a...

EPA recognizes the importance of nutrient criteria in protecting designated uses from eutrophication effects associated with elevated phosphorus and nitrogen in streams and has worked with states over the past 12 years to assist them in developing nutrient criteria. Towards that ...

The Markov Chain Nest Productivity Model (or MCnest) integrates existing toxicity information from three standardized avian toxicity tests with information on species life history and the timing of pesticide applications relative to the timing of avian breeding seasons to quantit...