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Records 26 to 50 of 1480 JOURNALs about 'CCTE' published after 10/28/2010

Effects of multi-walled carbon nanotubes on message and Micro-RNA in human lung BEAS-2B cells
(JOURNAL) [Published : Feb 01, 2024]
Multi-walled carbon nanotubes (MWCNTs) lack sufficient quality cytotoxicity, toxicity, genotoxicity and genomic data on which to make environmental and regulatory decisions. Therefore, we did a multidisciplinary in vitro study of 3 MWCNTs in human lung cells (BEAS-2B) w...
Establishing performance metrics for quantitative non-targeted analysis: a demonstration using per- and polyfluoroalkyl substances
(JOURNAL) [Published : Feb 01, 2024]
Non-targeted analysis (NTA) is an increasingly popular technique for characterizing undefined chemical analytes. Generating quantitative NTA (qNTA) concentration estimates requires the use of training data from calibration “surrogates,” which can yield diminished pred...
Effects of Age and Exposure Duration on the Sensitivity of Early Life Stage Fathead Minnow (Pimephales promelas) to Waterborne Propranolol Exposure
(JOURNAL) [Published : Jan 31, 2024]
Propranolol is a heavily prescribed, nonspecific beta-adrenoceptor (bAR) antagonist frequently found in wastewater effluents, prompting concern over its potential to adversely affect exposed organisms. In the present study, the transcriptional responses of 4, 5, and 6 days postfe...
Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data
(JOURNAL) [Published : Jan 30, 2024]
Background:  Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring...
High-Throughput Transcriptomics of Water Extracts Detects Reductions in Biological Activity with Water Treatment Processes
(JOURNAL) [Published : Jan 30, 2024]
The presence of numerous chemical contaminants from industrial, agricultural, and pharmaceutical sources in water supplies poses a potential risk to human and ecological health. Current chemical analyses suffer from limitations, including chemical coverage and high cost, and broa...
Suspect Screening Analysis of Pooled Human Serum Samples Using GC × GC/TOF-MS
(JOURNAL) [Published : Jan 30, 2024]
Humans interact with thousands of chemicals. This study aims to identify substances of emerging concern and in need of human health risk evaluations. Sixteen pooled human serum samples were constructed from 25 individual samples each from the National Institute of Environmental H...
Systematic update to the mammalian relative potency estimate database and development of best estimate toxic equivalency factors for dioxin-like compounds
(JOURNAL) [Published : Jan 25, 2024]
The World Health Organization (WHO) assesses potential health risks of dioxin-like compounds using Toxic Equivalency Factors (TEFs). This study systematically updated the relative potency (REP) database underlying the 2005 WHO TEFs and applied advanced methods for quantitative in...
Sublethal Toxicity of 17 Per- and Polyfluoroalkyl Substances with Diverse Structures to Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus
(JOURNAL) [Published : Jan 24, 2024]
Seven-day sublethal toxicity tests were performed with the freshwater invertebrates Ceriodaphnia dubia, Hyalella azteca, and Chironomus dilutus to determine the effects of per- or polyfluorinated alkyl substances (PFAS) of varying chain length within four clas...
High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions
(JOURNAL) [Published : Jan 23, 2024]
Traditionally, chemical toxicity is determined by in vivo animal studies, which are low throughput, expensive, and sometimes fail to predict compound toxicity in humans. Due to the increasing number of chemicals in use and the high rate of drug candidate failure due to toxicity, ...
Exploring the Effects of Experimental Parameters and Data Modeling Approaches on In Vitro Transcriptomic Point-of-Departure Estimates
(JOURNAL) [Published : Jan 01, 2024]
This sub-product is a journal article that compares a variety of computational approaches for calculating transcriptomic points of departure (tPODs) from in vitro high-throughput transcriptomics (HTTr) screening data.  The manuscript uses a data set of 44 chemicals tested in...
Screening for drinking water contaminants of concern using an automated exposure-focused workflow
(JOURNAL) [Published : Jan 01, 2024]
Background: The number of chemicals present in the environment exceeds the capacity of government bodies to characterize risk. Therefore, data-informed and reproducible processes are needed for identifying chemicals for further assessment. The Minnesota Department of Health (MDH)...
In vitro screening of per- and polyfluorinated substances (PFAS) for interference with seven thyroid hormone system targets across nine assays
(JOURNAL) [Published : Dec 27, 2023]
The US Environmental Protection Agency is evaluating the ecological and toxicological effects of per- and polyfluorinated chemicals. A number of perfluorinated chemicals have been shown to impact the thyroid axis in vivo suggesting that the thyroid hormone system i...
Survival, Growth, and Reproduction Responses in a Three-Generation Exposure of the Zebrafish (Danio rerio) to Perfluorooctane Sulfonate
(JOURNAL) [Published : Dec 26, 2023]
A prior multigenerational perfluorooctane sulfonic acid (PFOS) exposure investigation in zebrafish reported adverse effects at 0.734 µg/L, among the lowest aquatic effect levels for PFOS reported to date. The present three-generation PFOS exposure quantified survival, growt...
Models Used to Predict Chemical Bioaccumulation in Fish from in Vitro Biotransformation Rates Require Accurate Estimates of Blood–Water Partitioning and Chemical Volume of Distribution
(JOURNAL) [Published : Dec 23, 2023]
Methods for extrapolating measured in vitro intrinsic clearance to a whole-body biotransformation rate constant (kB) have been developed to support modeled bioaccumulation assessments for fish. The inclusion of extrapolated kB values into existing bioaccumulation models improves ...
A compartment model to predict in vitro finite dose absorption of chemicals by human skin
(JOURNAL) [Published : Dec 01, 2023]
Dermal uptake is an important and complex exposure route for a wide range of chemicals. Dermal exposure can occur due to occupational settings, pharmaceutical applications, environmental contamination, or consumer product use. The large range of both chemicals and scenarios of in...
Microglial Dynamics, Blood-Brain Barrier Morphogenesis, and Developmental Toxicity: a brief review and computational model
(JOURNAL) [Published : Dec 01, 2023]
Morphogenesis of the blood-brain barrier (BBB) is a complex process linked to neovascularization of the embryonic neural tube. This selective transport interface forms between vascular-neural compartments during organogenesis and dysregulation has be...
Quantitative Structure Use Relationships: Highlights from a technical summit meeting
(JOURNAL) [Published : Dec 01, 2023]
The Quantitative Structure Use Relationship (QSUR) Summit, held on November 2–4, 2022, focused on advancing the development, refinement, and use of QSURs to support chemical substance prioritization and risk assessment and mitigation. QSURs utilize chemical structures to pr...
Wetland water quality patterns and anthropogenic pressure associations across the continental USA
(JOURNAL) [Published : Dec 01, 2023]
Anthropogenic impacts on lake and stream water quality are well established but have been much less studied in wetlands.  Here we use data from the 2016 National Wetland Condition Assessment to characterize water quality and its relationship to anthropogenic pressure for inl...
Combination of computational new approach methodologies for enhancing evidence of biological pathway conservation across species
(JOURNAL) [Published : Nov 30, 2023]
The ability to predict which chemicals are of concern for environmental safety is dependent, in part, on the ability to extrapolate chemical effects across many species. This work investigated the complementary use of two computational new approach methodologies to support cross-...
Cross species extrapolation of the disruption of thyroid hormone synthesis by oxyfluorfen using in vitro data, physiologically based pharmacokinetic (PBPK), and thyroid hormone kinetics models
(JOURNAL) [Published : Nov 28, 2023]
Thyroid hormones play key roles in physiological processes such as regulation of the metabolic and cardiac systems as well as the development of the brain and surrounding sympathetic nervous system. Recent efforts to screen environmental chemicals for their ability to alter thyro...
Hepatic Transcriptome Comparative In Silico Analysis Reveals Similar Pathways and Targets Altered by Legacy and Alternative Per- and Polyfluoroalkyl Substances in Mice
(JOURNAL) [Published : Nov 28, 2023]
Per- and poly-fluoroalkyl substances (PFAS) are a large class of fluorinated carbon chains that include legacy PFAS, such as perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS). These compounds indu...
Dose Response, Dosimetric, and Metabolic Evaluations of Replacement PFAS Perfluoro-(2,5,8-trimethyl-3,6,9-trioxadodecanoic) Acid (HFPO-TeA)
(JOURNAL) [Published : Nov 23, 2023]
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicokinetics of a longer-chain PFECA...
Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application
(JOURNAL) [Published : Nov 21, 2023]
Assessing the ecological risk of contaminants in the field typically involves consideration of a complex mixture of compounds which may or may not be detected via instrumental analyses. Further, there are insufficient data to predict the potential biological effects of many detec...
Increased Endocrine Activity of Xenobiotic Chemicals as Mediated by Metabolic Activation.
(JOURNAL) [Published : Nov 21, 2023]
The US Environmental Protection Agency (USEPA) is faced with long lists of chemicals that require hazard assessment. The present study is part of a larger effort to develop in vitro assays and quantitative structure-activity relationships applicable to untested chemicals on USEPA...
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
(JOURNAL) [Published : Nov 21, 2023]
In October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF ...