Science Inventory

<< Previous

Next >>

Background: Chemicals in consumer products are a major contributor to human chemical coexposures. Consumers purchase and use a wide variety of products containing potentially thousands of chemicals. There is a need to identify potential real-world chemical coexposures to prioriti...

The US EPA is responsible for evaluating thousands of chemicals for the potential risks they may pose to humans and ecosystems, which necessitates information on hazard and exposure potential for each chemical. To support chemical decision-making, EPA's Office of Research and Dev...

There are a myriad of public free access chemistry databases now accessible to the community to source various types of data to support, for example, drug discovery, environmental chemistry and materials research. The US EPA CompTox Chemicals Dashboard is a web-based application ...

Understanding the metabolic fate of a chemical substance is important for evaluating its toxicity. Changes in the regulatory landscape of chemical safety assessment provide opportunities to use in silico tools for metabolism prediction. In this study, a set of 37 structurally div...

Quantitatively evaluating QSAR models is becoming more important and more challenging as the number of predictive models grows. The impact of experimental uncertainty on model evaluation has been recognized in the field, but a frequently held assumption is repeated throughout the...

N/A

Current environmental, social, and economic challenges have raised consciousness and led to incorporating the concept of sustainability and sustainable development into process design and optimization, such as pollution prevention and control, sustainable process design, sustaina...

Quantitative data on product chemical composition is necessary for characterizing consumer exposure to chemicals. EPA's Office of Research and Development (ORD) has built rapid models, including the High-Throughput Stochastic Human Exposure and Dose Simulation model (SHEDS-HT), t...

Chemical risk assessment requires information on hazard, exposure, and toxicokinetics (TK) relevant to the scenario, for example, consumer, ambient, or occupational exposure. Most non-pharmaceutical chemicals - for example, flame retardants, plasticizers, pesticides, solvents - d...

This meeting brings together an interagency community of stakeholders around exploring the link between military exposures and cancer.&nbsp;

High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry approaches for in vitro-in vivo extrapolation (IVIVE). With HTTK, the bioactivity identified by any in vitro assay can be converted to huma...

Chemical risk assessment requires information on hazard, exposure, and toxicokinetics (TK) relevant to the scenario, for example, consumer, ambient, or occupational exposure. Most non-pharmaceutical chemicals - for example, flame retardants, plasticizers, pesticides, solvents - d...

This study proposes methods to improve data mining workflows for modeling chemical manufacturing life cycle inventory. Secondary data sources can provide valuable information about environmental releases during chemical manufacturing. However, the often facility‐level nature of t...

For decades, targeted gas chromatography-mass spectrometry (GC-MS) methods have been used to carefully acquire measurement data in support of risk-based assessments of volatile and semi-volatile chemicals. While targeted measurements of known chemicals have supported most exposur...

This presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Also, this presentation...

Recent empirical evidence suggests that human occupants indoors influence the dynamics of SVOCs and associated human exposures. To better understand these dynamics, a transient multimedia human exposure model (ABICAM) was developed, which parameterizes mass-balance equations as f...

The presentation entitled &quot;High-Throughput Toxicokinetic Models and In Vitro-In Vivo Extrapolation (IVIVE)&quot; will describe efforts conducted in the strategic research area broadly entitled &quot;Rapid Exposure Modeling and Dosimetry.&quot; In this output, in vitro toxico...

This presentation will describe the latest NTA research in the CSS national research program (CSS 2.7)

The number of chemicals present in the human environment far exceeds the capacity of government bodies to fully characterize their risk. Therefore, scientifically sound processes are needed for screening chemicals and prioritizing them for further assessment. The Minnesota Depart...

Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their emergence, only a handful of mode...

Chemical evaluations require information to estimate exposure via a variety of high-priority pathways, including scenario-specific data and models particular to consumer products and materials in the indoor environment, as well as occupational, ambient and ecological pathways. Th...

This work provides an overview of efforts to predict exposure to workers in various occupations. We describe adaptations of existing occupational models for use in high-throughput situations. In addition, we also describe efforts to collect and assemble publicly-available measure...

This paper describes a modular mechanistic framework for predicting chemical emission from indoor sources, partitioning among indoor compartments and exposure to humans present in the indoor environment focusing on semi-volatile organic compounds (SVOCs). Important assumptions an...

When toxicokinetic (TK) variability occurs across different populations or lifestages, identical external chemical exposures may yield differing systemic concentrations, and may subsequently result in differing health impacts. In vitro -in vivo extrapolation (IVIVE) modeling that...

Time courses of compound concentrations in plasma are used in chemical safety analysis to evaluate the relationship between external administered doses and internal tissue exposures. This type of experimental data is rarely available for the thousands of non-pharmaceutical chemic...