Science Inventory

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Quantitative data on product chemical composition is necessary for characterizing consumer exposure to chemicals. EPA's Office of Research and Development (ORD) has built rapid models, including the High-Throughput Stochastic Human Exposure and Dose Simulation model (SHEDS-HT), t...

Chemical risk assessment requires information on hazard, exposure, and toxicokinetics (TK) relevant to the scenario, for example, consumer, ambient, or occupational exposure. Most non-pharmaceutical chemicals - for example, flame retardants, plasticizers, pesticides, solvents - d...

This meeting brings together an interagency community of stakeholders around exploring the link between military exposures and cancer.&nbsp;

High(er) throughput toxicokinetics (HTTK) encompasses in vitro measures of key determinants of chemical toxicokinetics and reverse dosimetry approaches for in vitro-in vivo extrapolation (IVIVE). With HTTK, the bioactivity identified by any in vitro assay can be converted to huma...

Chemical risk assessment requires information on hazard, exposure, and toxicokinetics (TK) relevant to the scenario, for example, consumer, ambient, or occupational exposure. Most non-pharmaceutical chemicals - for example, flame retardants, plasticizers, pesticides, solvents - d...

This study proposes methods to improve data mining workflows for modeling chemical manufacturing life cycle inventory. Secondary data sources can provide valuable information about environmental releases during chemical manufacturing. However, the often facility‐level nature of t...

For decades, targeted gas chromatography-mass spectrometry (GC-MS) methods have been used to carefully acquire measurement data in support of risk-based assessments of volatile and semi-volatile chemicals. While targeted measurements of known chemicals have supported most exposur...

This presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Also, this presentation...

Recent empirical evidence suggests that human occupants indoors influence the dynamics of SVOCs and associated human exposures. To better understand these dynamics, a transient multimedia human exposure model (ABICAM) was developed, which parameterizes mass-balance equations as f...

The presentation entitled &quot;High-Throughput Toxicokinetic Models and In Vitro-In Vivo Extrapolation (IVIVE)&quot; will describe efforts conducted in the strategic research area broadly entitled &quot;Rapid Exposure Modeling and Dosimetry.&quot; In this output, in vitro toxico...

This presentation will describe the latest NTA research in the CSS national research program (CSS 2.7)

The number of chemicals present in the human environment far exceeds the capacity of government bodies to fully characterize their risk. Therefore, scientifically sound processes are needed for screening chemicals and prioritizing them for further assessment. The Minnesota Depart...

Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their emergence, only a handful of mode...

Chemical evaluations require information to estimate exposure via a variety of high-priority pathways, including scenario-specific data and models particular to consumer products and materials in the indoor environment, as well as occupational, ambient and ecological pathways. Th...

This work provides an overview of efforts to predict exposure to workers in various occupations. We describe adaptations of existing occupational models for use in high-throughput situations. In addition, we also describe efforts to collect and assemble publicly-available measure...

This paper describes a modular mechanistic framework for predicting chemical emission from indoor sources, partitioning among indoor compartments and exposure to humans present in the indoor environment focusing on semi-volatile organic compounds (SVOCs). Important assumptions an...

When toxicokinetic (TK) variability occurs across different populations or lifestages, identical external chemical exposures may yield differing systemic concentrations, and may subsequently result in differing health impacts. In vitro -in vivo extrapolation (IVIVE) modeling that...

Time courses of compound concentrations in plasma are used in chemical safety analysis to evaluate the relationship between external administered doses and internal tissue exposures. This type of experimental data is rarely available for the thousands of non-pharmaceutical chemic...

We must consider exposure to identify chemical risk &ndash; for example, windows of developmental susceptibility and occupational exposure. In the U.S. both the toxic potency (hazard) and the magnitude of the exposure is needed to calculate risk. There are thousands of chemicals ...

Generic Scenarios were initially developed by the US Environmental Protection Agency (USEPA) as a part of the chemical risk assessments process required under the Toxic Substances Control Act (TSCA) used by the USEPA to evaluate the hazards associated with the modeled chemical. F...

This is the first part of a four-presentation continuing education course titled &quot;Applying Exposure New Approach Methodologies to Chemical Risk Evaluation&quot;, which will be presented at the ISES 2020 virtual meeting. This slide deck contains some introductory course slide...

Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the potential to accelerate the pace of human health safety evaluation by informing screening level assessments. The primary objective of this work was to compare PODs based on high-throug...

Background: High-throughput and computational tools provide a new opportunity to calculate cumulative bioactivity of exposure to diverse chemicals acting through a common mechanism. Objective: We used high throughput bioactivity data and exposure predictions from the U.S. EPA&rsq...

When toxicokinetic (TK) variability occurs across different populations or lifestages, identical external chemical exposures may yield differing systemic concentrations, and may subsequently result in differing health impacts. In vitro -in vivo extrapolation (IVIVE) modeling that...

Thousands of chemicals are present in the air we breathe, water we drink, food we eat, and materials we encounter. Routine environmental and biological monitoring has been performed on &lt;1% of these known compounds, owing to the exclusive use of targeted analytical methods, par...