Science Inventory

<< Previous

Next >>

EPA Releases new CompTox Chemicals Dashoard &ndash;&nbsp;The result of a two-year project to update the online tool's information technology architecture. New release maintains the established navigation users are accustomed to and&nbsp;enhances the user experience by implementin...

This invited keynote presentation provides compressive definitions regarding sustainable development, sustainability assessment and design, life cycle analysis, and their application in manufacturing more environmentally friendly chemicals with less occupational exposure. Similar...

Characterization of exposure risk for chemicals found in the environment is a task that often exceeds the capacity of government agencies due to the sheer number of chemicals found in the environment. Often, a manual screening process is performed using scientifically sound appro...

In this presenation we are presenting on the development and use Quantitative Stucture-Use Relationship Models for data relevant to exposure assessments and Aggregated Exposure Pathways as a tool to organize data and aid scientist performing exposure assessments.&nbsp;

Industrial producers and users of per- and polyfluorinated alkyl substances (PFAS) are a major source of chemical contamination to nearby communities due to historical releases of legacy PFAS. Following the general phase-out of legacy PFAS such as PFOA/PFOS, industrial usage has ...

&ldquo;The dose makes the poison&rdquo; &ndash; in other words, risk is a function of both hazard and exposure. New approach methodologies (NAMs) for hazards, such as&nbsp;in vitro&nbsp;high-throughput screening assays, can rapidly estimate hazards for thousands of chemicals. But...

Exposure to chemicals is influenced by associations between the individual&rsquo;s location and activities as well as demographic and physiological characteristics. Currently, many exposure models simulate individuals by drawing distributions from population-level data or use exp...

This work provides an overview of efforts to predict exposure to workers in various occupations. We describe adaptations of existing occupational models for use in high-throughput situations. In addition, we also describe efforts to collect and assemble publicly-available measure...

Per- and polyfluoroalkyl substances have been documented at all spatial scales with concerns of adverse ecological and human health effects. Human exposures and relative pathway contributions depend on the specific population, their exposure scenarios, and pathways of local sourc...

With the passing of the Frank R. Lautenberg Chemical Safety for the 21st Century Act, the Toxic Substances Control Act (TSCA) was amended to require risk assessors to consider susceptible or highly exposed subpopulations when prioritizing compounds for risk assessment. While high...

This general audience presentation discusses EPA data and research related to chemicals in cleaning products and introduces the concepts hazard, exposure, and risk.&nbsp;

This presenation is meant to educate scientists interesting in alternative assessments on the current efforts of ORD scientist to collect data related to exposure science, and how those data are made available to the public using EPA's CompTox Chemicals Dashboard.

This presentation will describe an application of NTA on drinking water filter data obtained via gas chromatography- high-resolution mass spectrometry. The application of semi-quantitative methods to estimate and statistically bound concentrations of known standard contaminants i...

Characterization of exposure risk for chemicals found in the environment is a task that often exceeds the capacity of government agencies due to the sheer number of chemicals found in the environment. Often, a manual screening process is performed using scientifically sound appro...

This presentation of the EPA ORD vision for exposure modeling describes a conceptual framework for computational exposure science and provides some illustrative examples of research being conducted using chemical ingredients of consumer products as an example.

There is a need to rapidly prioritize large numbers of chemicals according to potential risk. Risk is a function of both hazard and exposure, so we need to rapidly predict potential exposures. The US EPA ExpoCast project develops exposure NAMs (new approach methodologies) that 1)...

The inhalation route of chemical exposure is important for both occupational and general population exposures. Unfortunately, in vivo data describing chemical toxicokinetics (that is, absorption, distribution, metabolism, and excretion) are typically unavailable for the chemicals...

Recycled materials are found in many consumer products as part of a circular economy; however, the chemical content of recycled products is generally uncharacterized. A suspect screening analysis using two-dimensional gas chromatography time-of-flight mass spectrometry (GC &times...

High resolution mass spectrometry (HRMS) and non-targeted analysis (NTA) are utilized to identify emerging contaminants and chemical signatures of interest detected in various media. At the US Environmental Protection Agency the CompTox Chemicals Dashboard (https://comptox.epa.go...

Background: Chemicals in consumer products are a major contributor to human chemical coexposures. Consumers purchase and use a wide variety of products containing potentially thousands of chemicals. There is a need to identify potential real-world chemical coexposures to prioriti...

The US EPA is responsible for evaluating thousands of chemicals for the potential risks they may pose to humans and ecosystems, which necessitates information on hazard and exposure potential for each chemical. To support chemical decision-making, EPA's Office of Research and Dev...

There are a myriad of public free access chemistry databases now accessible to the community to source various types of data to support, for example, drug discovery, environmental chemistry and materials research. The US EPA CompTox Chemicals Dashboard is a web-based application ...

Understanding the metabolic fate of a chemical substance is important for evaluating its toxicity. Changes in the regulatory landscape of chemical safety assessment provide opportunities to use in silico tools for metabolism prediction. In this study, a set of 37 structurally div...

Quantitatively evaluating QSAR models is becoming more important and more challenging as the number of predictive models grows. The impact of experimental uncertainty on model evaluation has been recognized in the field, but a frequently held assumption is repeated throughout the...

N/A