Science Inventory

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This release of SHEDS-HT (v0.1.10) updates the model to include input data developed from EPA's Chemicals and Products Database (CPDat) Version 3. Other changes include:   - Updated function documentation- Updated functionality with regard to SHEDS-HH home location set-up- A...

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Evidence suggests that clothing can influence human exposure to semi-volatile organic compounds (SVOCs) through transdermal uptake and inhalation. Accordingly, a computational modeling framework (ABICAM) was expanded and applied to assess the dynamics of human exposure to gas-pha...

Background: The number of chemicals present in the environment exceeds the capacity of government bodies to characterize risk. Therefore, data-informed and reproducible processes are needed for identifying chemicals for further assessment. The Minnesota Department of Health (MDH)...

Background and Purpose An ongoing and primary research endeavor of the US EPA includes the evaluation of chemical risk to environmental and human health as well as modes of traversal from commercial sources and industrial processes to environmental and ecological media (including...

Abstract for invited SOT 2024 session "Practical applications of machine learning for gaining mechanistic insights in toxicology" Monitoring of chemical occurrence in various environmental media is gold-standard information for characterizing the mechanisms by which hum...

Under the Toxic Substances Control Act (TSCA), the US Environmental Protection Agency (US EPA) is required to determine whether a chemical substance poses an unreasonable risk before the chemical is manufactured in or imported into the United States. This presentation provides an...

Under the Toxic Substances Control Act (TSCA), the US Environmental Protection Agency (US EPA) is required to determine whether a chemical substance poses an unreasonable risk before the chemical is manufactured in or imported into the United States. This presentation will provid...

The national-scale assessment of air toxics risks is a modeling assessment which combines emission inventory development, atmospheric fate and transport modeling, exposure modeling, and risk assessment to characterize the risk associated with inhaling air toxics from outdoor sour...

There is growing interest in promoting the treatment and beneficial re-use of production water from onshore oil & gas operations. A significant challenge to re-use strategies is the variable and complex chemical composition of produced waters. Produced waters (PW) may come from m...

Under the Toxic Substances Control Act (TSCA), the United States Environmental Protection Agency (USEPA) is required to determine whether a new chemical substance poses an unreasonable risk to human health or the environment before the chemical is manufactured in or imported into...

We present a Northern European case study from the SETAC Pellston workshop in June 2022 on integration of global climate change (GCC) modeling into ecological risk assessment. In Northern Europe, GCC is expected to result in increased temperatures and precipitation. The changes i...

This is a training presentation to the EPA Tools and Resources Webinar. The ChemExpo Knowledgebase is a new ORD tool for disseminating information on how chemicals are used in commerce, including in consumer products.

Exposure to fine particulate matter (PM2.5) from wildfire smoke is an important and growing risk to public health. Reducing personal exposure from public health actions can minimize adverse health effects associated with PM2.5 from wildfire smoke. To motivate individuals to modif...

This talk provides a high-level overview of the work going on in EPA's ExpoCast research program, including the development of NAMs for exposure and statistical frameworks for building consensus models.

Chemicals in consumer products are a major contributor to human chemical coexposures. Consumers purchase and use a wide variety of products containing potentially thousands of chemicals. There is a need to identify potential real-world chemical coexposures to prioritize in v...

Epidemiologic studies of ambient fine particulate matter (PM2.5) and ozone (O3) often use outdoor concentrations as exposure surrogates, which can induce measurement error. We developed an exposure model called TracMyAir, which is an iPhone application that determines eight tiers...

This indicator describes trends in dietary exposures (food alone) to two classes of pesticides: N-methyl carbamates (NMC) and organophosphates (OP). The indicator considers exposure from multiple foods and determines a combined toxicity-weighted exposure to these pesticides which...

Regulatory changes in chemical safety assessment have sought to supplant animal testing with high-throughput screening and in silico modeling. In conjunction with these regulatory changes, metabolism prediction software have seen significant growth in recent years and can support...

With the passing of the Frank R. Lautenberg Chemical Safety for the 21st Century Act, the Toxic Substances Control Act (TSCA) was amended to require risk assessors to consider susceptible subpopulations when prioritizing compounds for risk assessment. While high-throughput consum...

Human exposure to volatile organic compounds (VOCs) from indoor sources including consumer products is a public health concern that is understudied. In the context of a 10-day nine-person pilot study designed to test and demonstrate methods for monitoring personal VOC exposures, ...

This subproduct is an invited talk for the 2023 EPA FSTRAC meeting, describing the collaboration between EPA and Minnesota Department of Health to develop a rapid exposure screening workflow for emerging contaminants of concern in drinking water.

The U.S. Environmental Protection Agency’s (EPA) Exposure Forecasting (ExpoCast) project has developed high-throughput (HT) models for estimating population exposures to thousands of chemicals for use in chemical prioritization. Within the ExpoCast Systematic Empirical Eval...

We categorized more than 60,000 chemical substances by broad pathways of exposure: consumer, industrial, pesticide, food, pharmaceuticals, and other pathways.  These pathway categorizations can be used as a training set for automated read-across of chemical exposure pathways...