Science Inventory

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The focus of this meeting is the SAP's review and comment on the Agency's proposed high-throughput computational model of androgen receptor pathway activity as an alternative to the current Tier 1 androgen receptor assay (OCSPP 890.1150: Androgen Receptor Binding Rat Prostate Cyt...

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors, leading to fetal skeleton malformations. Here, a data-driven model was constructed to identify chemicals associated with both ATR...

Predictive, mechanism-based approaches to assessing the toxicity of contaminant mixtures have been largely limited to chemicals that exert effects through the same biological target/molecular initiating event (MIE). However, through understanding specific pathways through which c...

There is no abstract asociated with this presentation. However, this work provides a high level overview of: &middot;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; The Value of Harnessing Artificial Intelligence (machine learning, natural language processing, and automated data extraction)...

The workshop titled &ldquo;Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks&rdquo; was co-organized by the Evidence-based Toxicology Collaboration and the European Food Safety Authority (EFSA), and hosted by EFSA at its headquarte...

The workshop &ldquo;Application of evidence-based methods to construct mechanistic frameworks for the development and use of non-animal toxicity tests&rdquo; was organized by the Evidence-based Toxicology Collaboration and hosted by the Grading of Recommendations Assessment, Deve...

Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical activity toward DIOs is being...

In a century where toxicology and chemical risk assessment are embracing alternative methods to animal testing, there is an opportunity to understand the causal factors of neurodevelopmental disorders such as learning and memory disabilities in children, as a foundation to predic...

The US EPA Endocrine Disruptor Screening Program has identified several molecular thyroid targets relevant to hormone synthesis dynamics that have been adapted to high-throughput screening assays to rapidly evaluate the ToxCast/Tox21 chemical inventories for potential thyroid dis...

This presentation will provide a high-level overview of the application of toxicogenomics at the US EPA, including 1) Evolution in the application of toxicogenomics at EPA, 2) More recent frameworks for applying toxicogenomics, 3) Examples of ongoing EPA research for toxicogenomi...

The uterine artery undergoes significant remodeling during pregnancy including alterations in length, diameter, and contractility. In line with these changes to the uterine vascular system, is a reduction in vascular resistance, permitting increased blood flow to the fetoplacenta...

The adverse outcome pathway (AOP) framework provides a practical means for organizing scientific knowledge that can be used to infer cause-effect relationships between stressor events and toxicity outcomes in intact organisms. It has reached wide acceptance as a tool to aid chemi...

The adverse outcome pathway (AOP) is a conceptual construct that facilitates organisation and interpretation of mechanistic data representing multiple biological levels and deriving from a range of methodological approaches including&nbsp;in silico,&nbsp;in vitro&nbsp;and&nbsp;in...

Laboratory experiments have established that exposure to certain endocrine-active substances prior to and/or during the period of sexual differentiation can lead to skewed sex ratios in fish. However, the potential long-term population impact of a biased sex ratio depends on mult...

Adequate supplies of iodine are essential for production of the iodinated hormones of the thyroid gland. A number of environmental contaminants have been identified that interfere with the transport of iodine into the thyroid gland with the potential to reduce thyroid hormone (TH...

Humans are exceedingly exposed to various chemicals over a lifetime, of which more than 100,0000 require testing for potential adverse effects. The National Academy of Science has suggested utilizing advances in molecular biology to identifying adverse outcome pathways (AOPs) for...

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors, leading to fetal skeleton malformations. Here, a data-driven model was constructed to identify chemicals associated with both ATR...

Organisms are exposed to ever-changing complex mixtures of chemicals over the course of their lifetime. The need to more comprehensively describe this exposure and relate it to adverse health effects has led to formulation of the exposome concept in human toxicology. Whether this...

All-trans retinoic acid (ATRA) gradients determine skeletal patterning morphogenesis and can be disrupted by diverse genetic or environmental factors, leading to fetal skeleton malformations. Adverse Outcome Pathway (AOP) frameworks for ATRA metabolism, signaling, and homeostasis...

Despite over 50 years of research on the use of population models in chemical risk assessment, their practical utility has remained elusive. A novel application and interpretation of ecotoxicological models, Endogenous Lifecycle Models (ELM), is proposed that offers some of the b...

There is a need for more efficient use of existing data to characterize human toxicological response data for environmental chemicals in the US and Europe. The Adverse Outcome Pathway (AOP) framework helps to organize existing mechanistic information, where AOP knowledge and data...

Despite over 50 years of research on the use of population models in chemical risk assessment, their practical utility has remained elusive. A novel application and interpretation of ecotoxicological models, Endogenous Lifecycle Models (ELM), is proposed that offers some of the b...

Adverse outcome pathways (AOPs) are used to encode structured toxicological knowledge.&nbsp; User-contributed online knowledgebases, such as the AOPWiki, contain AOPs that span diverse biological and toxicological domains.&nbsp; When AOPs are shared publicly, contributors are doi...

The ECOTOXicology Knowledgebase (ECOTOX) has been locating and curating ecologically-relevant toxicity data for over 30 years and is now a nationally and internationally recognized source of single-chemical toxicity test results for aquatic and terrestrial organisms. Through deca...

The adverse outcome pathway (AOP) framework captures and organizes existing biological pathway knowledge from the literature to direct research efforts and aid in risk assessment. This existing knowledge along with continuously expanding sequence data may also be used to define t...