Science Inventory

<< Previous

Next >>

Adverse neurodevelopmental consequences remain a primary concern when evaluating the effects of thyroid disrupting chemicals (TDC). The inherent complexity of the thyroid system allows for a variety of potential target sites for chemical interference and disruption of the system....

Omics approaches incorporated into standard toxicity tests can provide valuable information that can be used to inform the ecological risk assessment process. Specifically, the field of toxicogenomics, and its subdisciplines of transcriptomics, proteomics and metabolomics, can be...

Quantitative adverse outcome pathways (qAOPs) describe quantitative response-response relationships linking the molecular initiating event (MIE) and adverse outcome (AO) to enable quantitative prediction of the probability of occurrence or severity of an AO for a given magnitude ...

The Computational Toxicology Program within the U.S. Environmental Protection Agency (EPA) integrates advances in biology, chemistry, and computer science to help prioritize chemicals for further research based on potential human and environmental health risks. A key component o...

The evaluation of potential alternatives for chemicals of concern (CoC) requires an understanding of their potential human health and environmental impacts during the manufacture, use, recycle and disposal life stages. During the manufacturing phase, the processes used to produce...

Screening technologies have been developed to identify xenobiotic chemicals that bind nuclear receptors and thus have potential for adverse health effects through disruption of endocrine function. However, the focus has been on human receptors despite environmental exposure to a ...

The prostate is an androgen-dependent tissue that is an important site of disease in human males as well as an important indicator of androgen status in animals. The rat prostate is used for studying antiandrogenic drugs as well as for evaluation of endocrine disruption (e.g., He...

Major elements of the debate over endocrine disruption have revolved around dose-response behaviors for endocrine-mediated effects. Several modeling projects are underway or planned as part of this effort. Near-term efforts are based upon modeling existing scientific literature,...

The Agency frequently encounters situations where it must make decisions about the potential health and environmental effects of chemicals when all of the relevant data is not available. One rational approach to this problem is to estimate the relevant missing information by ext...

Over the past decade there has been a focused international effort to identify possible adverse effects of EDCs on humans and wildlife. Effects on reproduction and development mediated through alterations in the HPG axis have been of particular concern (USEPA 1998). There is co...

A Java-based web service was developed within the US EPA&rsquo;s Chemistry Dashboard to provide real time estimates of toxicity values and physical properties. WebTEST can generate toxicity predictions directly from a simple URL which includes the endpoint, QSAR method, and SMILE...

Synthesis of 11 steroid hormones in the human adrenocortical carcinoma cell line, H295R, was measured in a high-throughput steroidogenesis assay (HT-H295R) as part of the US Environmental Protection Agency’s ToxCast program for 656 chemicals in multi-concentration response. This ...

Understanding the estrogenic potential of phenones and hydroxy benzophenones, which are widely used as UV radiation filters, and in the manufacturing of insecticides and pharmaceuticals, is of interest to the US and other international environmental organizations. The estrogenic ...

Abstract describing value of specific water quality monitoring approach and overall conclusions after multiple years of application of tools to several case studies. Summary will be presented in platform format to attendees of the 2018 National Water Quality Monitoring Council Me...

Disruption of thyroid hormone signaling is a form of endocrine disruption that is of concern to both human health and ecosystems. Research is being conducted to define the biological targets chemicals may interact with to disrupt thyroid hormone signaling and the stages in develo...

Chemicals in the environment can prevent proper reproduction in fish. However, it was unknown whether models developed using data collected from the commonly studied fathead minnow could accurately predict adverse effects to other fish species. Results of our study suggest that t...

Since the 1940s, effluent toxicity testing has been used to assess potential ecological impacts of effluents and help determine necessary treatment options for environmental protection prior to release. Strategic combinations of toxicity tests, analytical tools, and biological mo...

The evaluation of potential alternatives for chemicals of concern requires understanding the implications of the chemical of concern during the manufacture, use, and disposal phases of its life cycle. Identifying potential reaction pathways and synthesis routes is an important co...

In vitro/alternative and computational approaches are valuable for chemical prioritization, especially where we understand the targets and toxicity pathways. Nuclear receptors are an inherently important target of environmental chemicals. Endocrine disruption is one important mod...

Abstract describing study design, results and conclusions will be presented in poster or platform format to attendees of the 2018 Society of Environmental Toxicology and Chemistry annual meeting pending acquisition of travel funds. Abstract: Endocrine disrupting compounds are pe...

Chemicals in the environment can prevent proper reproduction in fish. However, it was unknown whether models developed using data collected from the commonly studied fathead minnow could accurately predict adverse effects to other fish species. Results of our study suggest that t...

The Medaka Extended One Generation Reproduction Test (MEOGRT) is part of the U.S. Environmental Protection Agency&rsquo;s (USEPA) Endocrine Disruptor Screening Program (EDSP) designed to characterize the potential adverse effects to fish of a chemical through endocrine disruption...

High-throughput transcriptomic (HTTr) technologies are increasingly being used to screen environmental chemicals in vitro to provide mechanistic context for regulatory testing. The development of gene expression biomarkers that accurately predict molecular and toxicological effec...

Identification of chemicals that affect hormone-regulated systems will help to predict endocrine disruption. In our previous study we characterized a gene expression biomarker that was found to be an accurate predictor of ER&amp;alpha; modulation in chemically-treated human breas...

An alternatives assessment facilitates a comparison of potential alternatives to a chemical of concern. Alternatives assessment should include life-cycle considerations to account for releases and exposures that occur during the extraction, manufacturing, use, and disposal phases...