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Records 1 to 25 of 3367 records about 'CCTE' published after 07/01/2017

Utility of Developmental Neurotoxicity In Vitro Battery to Address Regulatory Challenges (SOT of Canada)
(PRESENTATION) [To be presented : Dec 05, 2023]
Limitations to the in vivo developmental neurotoxicity (DNT) test includes high variability, low reproducibility, and unknown human relevance. Moreover, neuropathological assessments in the DNT guideline are challenging due to methodology, lack of mechanistic understanding, and t...
Improving Sensitivity and Specificity of Larval Zebrafish Behavior Assays through Identification of Negative Control Chemicals
(PRESENTATION) [Presented : Nov 16, 2023]
Identifying reliable negative control compounds is integral to determining the sensitivity and specificity of chemical exposure assays. This abstract describes the steps taken to identify negative controls to assess chemicals for developmental neurotoxicity potential using screen...
Navigating the Complex Landscape of Human Biomonitoring Data for Chemistry and Exposure Assessment
(PRESENTATION) [Presented : Nov 16, 2023]
Biomonitoring data can provide important information about exposure to chemicals in the environment aggregated across all pathways. Depending on the study design, biomonitoring surveys can elucidate population-specific risks, exposure patterns over time, and relationships between...
Computational Embryology and Predictive Toxicology ACT Nov 2023)
(PRESENTATION) [Presented : Nov 15, 2023]
Scientific and practical needs exist for a different way to predict human developmental toxicity with less reliance on animal testing. The term New Approach Methods (NAMs) refers to any technology, methodology, approach, or combination thereof that can be used to provide informat...
Computational approaches to evaluating developmental neurotoxicity (DNT) new approach methods (NAMs)
(PRESENTATION) [Presented : Nov 15, 2023]
Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop  
Establishing Confidence in DNT-NAMs for Regulatory Use
(PRESENTATION) [Presented : Nov 15, 2023]
Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop
Progress in Linking DNT In Vitro Battery Endpoints to Adverse Outcome Pathways
(PRESENTATION) [Presented : Nov 15, 2023]
Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop
Using Cheminformatics Approaches to Develop a Structure Searchable Database of Analytical Methods (SCIEX 2023)
(PRESENTATION) [Presented : Nov 15, 2023]
Analytical methods can vary in nature from detailed regulatory methods to more summary in nature. Instrument vendors also provide access to many hundreds of application notes which can be considered as summary methods. The US-EPA has developed a cheminformatically enabled databas...
Embryology: From Fertilization to Neural Tube and Somite Formation
(PRESENTATION) [Presented : Nov 04, 2023]
Embryogenesis progresses from the fusion of the egg and sperm through many critical processes to establish the embryo proper. This lecture will describe and discuss those processes. Fusion of the sperm and egg establishes the one cell zygote. Continued cellular division, initiati...
Reproducibility of organ-level effects in repeat dose animal studies
(JOURNAL) [Published : Nov 01, 2023]
This work estimates benchmarks for new approach method (NAM) performance in predicting organ-level effects in repeat dose studies of adult animals based on variability in replicate animal studies. Treatment-related effect values from the Toxicity Reference dat...
Biosolids Pollutant Prioritization (PFAS Science call for State and Tribal partners)
(PRESENTATION) [Presented : Oct 30, 2023]
The Clean Water Act requires Office of Water (OW) to evaluate chemicals that occur in biosolids for harm to human health and the environment. OW developed a screening tool (BST) to evaluate risk for these chemicals. A prioritization process is needed to help determine which chemi...
Characterizing Metabolic similarity within GenRA: MetGraph
(PRESENTATION) [Presented : Oct 28, 2023]
EPA’s non-targeted analysis webapp: aligning web-based software tools with best practices for NTA
(PRESENTATION) [Presented : Oct 28, 2023]
Targeted methods have long been the gold standard in chemical monitoring for exposure assessment. However, with the increased need to identify emerging contaminants, monitoring studies have shifted towards approaches like non-targeted analysis (NTA) utilizing high-resolution mass...
Internal dose and in-life results after short-term exposure of rats to short-chain PFAS
(PRESENTATION) [Presented : Oct 28, 2023]
Per- and polyfluoroalkyl substances (PFAS) are a diverse array of more than 10,000 chemicals that are widely used in manufacturing and consumer products due to beneficial properties such as strong C-F bonds and resistance to water, oil, and grease. The environmental distribution ...
Molecular Representations to Improve Chemical Modeling and Ontology in Relation to Environmental Chemistry Properties & Outcomes
(PRESENTATION) [Presented : Oct 28, 2023]
The success of any effort to model environmental chemistry outcomes, be they fate, transport, transformation, or bioactivity, relies upon suitable cognition and representation of the underlying and causative chemistry. The way in which chemistry is encoded, which can include trad...
Opportunities for Collaboration and Action beyond the Award Period
(PRESENTATION) [Presented : Oct 28, 2023]
Presentation to EPA STAR grantees on opportunities for collaboration.
Quality assurance and quality control workflow for the non-targeted analysis of de facto water reuse
(PRESENTATION) [Presented : Oct 28, 2023]
Non-targeted analysis (NTA) studies of environmental systems generate a wealth of data that can be used to identify unexpected and/or unknown compounds that may affect human and ecological health. Though abundant environmental data ultimately enables a more complete assessment of...
The US-EPA Chemical Transformations Database (CHET): A novel web application for storage, presentation, and comparative analysis of chemical transformations
(PRESENTATION) [Presented : Oct 28, 2023]
Exposure and risk assessments generally focus on chemicals in their manufactured form, but most organic chemicals transform when they react with water, sunlight, heat and other environmental conditions or are metabolized. These transformation products can have very different phys...
A Binary Classification Approach to Predicting Molecular Initiating Events from High Throughput Transcriptomics Data (NURA 2023)
(PRESENTATION) [Presented : Oct 27, 2023]
Presentation to the New Approach Methodology (NAM) Use for Regulatory Application (NURA): AI Use for Regulatory Application: Using machine learning to reduce animal use in toxicology webinar October 2023
Briefing on the Draft EPA Transcriptomic Assessment Product (ETAP)
(PRESENTATION) [Presented : Oct 26, 2023]
Presentation to the EPA Executive Board of Scientific Counselors (BOSC) Committee Meeting October 2023
Value of Information Case Study
(PRESENTATION) [Presented : Oct 26, 2023]
Value-of-information (VOI) is a method for quantifying the expected gain in economic terms of reducing uncertainty through the collection of additional data. The VOI framework provides a basis for objectively evaluating trade-offs between timeliness, uncertainty, and cost in toxi...
In Vitro New Approach Methods (NAMs) for Chemical Bioactivity Screening and Applications to Risk Assessment
(PRESENTATION) [Presented : Oct 25, 2023]
New Approach Methodologies (NAMs) promise to offer a unique opportunity to enable human-relevant safety decisions to be made without the need for animal testing. The aim of this continuing education course is to bring to life the use and application of NAMs in safety decision-mak...
EPA Research: Lessons from Toxicology NAMs
(PRESENTATION) [Presented : Oct 20, 2023]
The NIH is conducting planning activities to inform a potential Common Fund research program called Complement Animal Research In Experimentation (Complement-ARIE) aimed at development, standardization, validation, and use of new methods and approaches that will more accurately m...
NAMs 101: The Basics and the EPA NAM Work Plan
(PRESENTATION) [Presented : Oct 18, 2023]
The term ‘New Approach Methods’ (NAMs) has multiple definitions depending on the organization, but it is generally a broadly descriptive reference to non-animal methods that can be used in chemical hazard assessment. Many of the underlying drivers in the development o...