Science Inventory

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Limitations to the in vivo developmental neurotoxicity (DNT) test includes high variability, low reproducibility, and unknown human relevance. Moreover, neuropathological assessments in the DNT guideline are challenging due to methodology, lack of mechanistic understanding, and t...

Identifying reliable negative control compounds is integral to determining the sensitivity and specificity of chemical exposure assays. This abstract describes the steps taken to identify negative controls to assess chemicals for developmental neurotoxicity potential using screen...

Biomonitoring data can provide important information about exposure to chemicals in the environment aggregated across all pathways. Depending on the study design, biomonitoring surveys can elucidate population-specific risks, exposure patterns over time, and relationships between...

Scientific and practical needs exist for a different way to predict human developmental toxicity with less reliance on animal testing. The term New Approach Methods (NAMs) refers to any technology, methodology, approach, or combination thereof that can be used to provide informat...

Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop  

Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop

Presentation to The Joint Institute for Food Safety and Applied Nutrition (JIFSAN): State of the Science on Assessing Developmental Neurotoxicity (DNT) Using New Approach Methods (NAMs) Workshop

Analytical methods can vary in nature from detailed regulatory methods to more summary in nature. Instrument vendors also provide access to many hundreds of application notes which can be considered as summary methods. The US-EPA has developed a cheminformatically enabled databas...

Embryogenesis progresses from the fusion of the egg and sperm through many critical processes to establish the embryo proper. This lecture will describe and discuss those processes. Fusion of the sperm and egg establishes the one cell zygote. Continued cellular division, initiati...

This work estimates benchmarks for new approach method (NAM) performance in predicting organ-level effects in repeat dose studies of adult animals based on variability in replicate animal studies. Treatment-related effect values from the Toxicity Reference dat...

The Clean Water Act requires Office of Water (OW) to evaluate chemicals that occur in biosolids for harm to human health and the environment. OW developed a screening tool (BST) to evaluate risk for these chemicals. A prioritization process is needed to help determine which chemi...

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Targeted methods have long been the gold standard in chemical monitoring for exposure assessment. However, with the increased need to identify emerging contaminants, monitoring studies have shifted towards approaches like non-targeted analysis (NTA) utilizing high-resolution mass...

Per- and polyfluoroalkyl substances (PFAS) are a diverse array of more than 10,000 chemicals that are widely used in manufacturing and consumer products due to beneficial properties such as strong C-F bonds and resistance to water, oil, and grease. The environmental distribution ...

The success of any effort to model environmental chemistry outcomes, be they fate, transport, transformation, or bioactivity, relies upon suitable cognition and representation of the underlying and causative chemistry. The way in which chemistry is encoded, which can include trad...

Presentation to EPA STAR grantees on opportunities for collaboration.

Non-targeted analysis (NTA) studies of environmental systems generate a wealth of data that can be used to identify unexpected and/or unknown compounds that may affect human and ecological health. Though abundant environmental data ultimately enables a more complete assessment of...

Exposure and risk assessments generally focus on chemicals in their manufactured form, but most organic chemicals transform when they react with water, sunlight, heat and other environmental conditions or are metabolized. These transformation products can have very different phys...

Presentation to the New Approach Methodology (NAM) Use for Regulatory Application (NURA): AI Use for Regulatory Application: Using machine learning to reduce animal use in toxicology webinar October 2023

Presentation to the EPA Executive Board of Scientific Counselors (BOSC) Committee Meeting October 2023

Value-of-information (VOI) is a method for quantifying the expected gain in economic terms of reducing uncertainty through the collection of additional data. The VOI framework provides a basis for objectively evaluating trade-offs between timeliness, uncertainty, and cost in toxi...

New Approach Methodologies (NAMs) promise to offer a unique opportunity to enable human-relevant safety decisions to be made without the need for animal testing. The aim of this continuing education course is to bring to life the use and application of NAMs in safety decision-mak...

The NIH is conducting planning activities to inform a potential Common Fund research program called Complement Animal Research In Experimentation (Complement-ARIE) aimed at development, standardization, validation, and use of new methods and approaches that will more accurately m...

The term ‘New Approach Methods’ (NAMs) has multiple definitions depending on the organization, but it is generally a broadly descriptive reference to non-animal methods that can be used in chemical hazard assessment. Many of the underlying drivers in the development o...