Science Inventory

Next >>

Metabolomics is an emerging tool to predict changes in an organism’s pathophysiological state prior to the onset of overt toxicity.  Although useful for providing insight into biochemical changes in ecological toxicity studies, the use of metabolomics data in the regul...

An in vitro method (OECD TG 249) using rainbow trout (Oncorhynchus mykiss) gill cells (RTgill-W1) in a plate-reader based viability assay (CV-PR) has been developed as a potential alternative to acute fish toxicity tests. We miniaturized this existing New Approach Method (NAM) fr...

The ECOTOXicology Knowledgebase (ECOTOX) is a comprehensive, publicly available resource providing single chemical environmental toxicity data on aquatic life, terrestrial plants, and wildlife. The database is updated quarterly, and to identify relevant references and extract per...

Cyanobacteria associated with Harmful Algal Blooms (HABs) can release highly potent toxins, known as cyanotoxins, which can be deadly to humans, pets, and livestock. Acute and chronic effects are not well characterized across the diversity of cyanotoxins or the potentially expose...

The ECOTOXicology Knowledgebase (ECOTOX) is a nationally and internationally recognized source of curated, single-chemical toxicity data for aquatic and terrestrial organisms. ECOTOX has been locating and curating ecotoxicity data using systematic and transparent literature revie...

Concentrations at which global gene expression profiles in cells or animals exposed to a test substance start to differ significantly from those of controls have been proposed as an alternative point of departure for use in screening level hazard assessment. The present study des...

FY22 Quick Guide: Periodical updates are required for the ECOTOX end user documentation. This ECOTOX Quick User Guide provides a simple, two-page reference document on the methods and features available for querying information in the ECOTOX Knowledgebase. This brief summary of t...

FY22 User Guide: Periodical updates are required for the ECOTOX end user documentation. This User Guide provides documentation on utilizing and searching for information in the ECOTOX Knowledgebase to help users easily retrieve information from the electronic database through the...

Endangered Species Act (ESA) consultations are required when a proposed federal action overlaps a listed species range or designated critical habitat. As part of its ESA consultations, the U.S. Environmental Protection Agency develops species-specific toxicity analyses for each c...

Cyanotoxins associated with Harmful Algal Blooms (HABs) can be deadly to humans, pets, and livestock. Impacts of cyanotoxins on other organisms (e.g., microbes, plants, and wildlife) are not well characterized. Our goal was to comprehensively and systematically assemble available...

Large repositories of new approach methodology (NAM)-based data, such as the high-throughput, mammalian-centric in vitro bioactivity data in the EPA’s Toxicity Forecaster (ToxCast), provide a wealth of publicly accessible toxicity information for thousands of chemicals. The...

No one tool or methodology can provide all necessary information regarding the impacts of a chemical to a species, let alone to the diversity of species. Transparent, scientifically supported development of tools that strategically connect to one another to fulfill data and knowl...

This product will be comprised of updates each quarter in FY22 to the public-facing ECOTOX Knowledgebase website (data uploaded and changes to software/user interface).

The ECOTOX Knowledgebase is a comprehensive web-based database compiled and maintained by ORD-Duluth to provide information of the effects of chemicals on ecologically-relevant aquatic and terrestrial organisms (www.epa.gov/ecotox/). The data in ECOTOX are extracted from peer-rev...

This product will be comprised of updates of PFAS data each quarter in FY22 to the public-facing ECOTOX Knowledgebase website.

Toxicity test results from ECOTOX are used in multiple applications and assessments. For these, the data analysis, synthesis, and interpretation of toxicity results are application- or assessment-specific, and thus conducted outside of the ECOTOX. ECOTOX data extraction includes ...

This product will be comprised of updates each quarter in FY21 to the public-facing ECOTOX Knowledgebase website (data uploaded and changes to software/user interface).

This product will be comprised of updates each quarter in FY21 to the public-facing ECOTOX Knowledgebase website.

In a study of 44 diverse sampling sites across 16 Great Lakes tributaries, 110 pharmaceuticals were detected of 257 monitored. The present study evaluated the ecological relevance of detected chemicals and identified heavily impacted areas to help inform resource managers and gui...

Each year, as the sheer amount of chemicals readily available to the market increases, so does the need for short-term and cost effective high-throughput assays that can be used to evaluate chemical potency and infer potential hazards to human health and/or ecosystems. Over the p...

To keep pace with the introduction of new chemicals to the marketplace, it is important to develop rapid, cost-effective, and efficient assays to evaluate the hazard(s) those chemicals may pose to ecosystems and human health. While an abundance of high throughput assays for evalu...

In a study of 44 sampling sites within 16 Great Lakes tributaries, 113 pharmaceuticals and personal care products (PPCPs) were detected of 261 monitored. Sampling sites were selected to represent a gradient of land uses and wastewater treatment plant (WWTP) influence. In some cas...

As part of the Great Lakes Restoration Initiative, extensive contaminant monitoring, including 830 unique compounds, was conducted in Great Lakes tributaries over the course of eight years.  The goal was to support the aim of identifying significant sources and impacts of ne...

The ECOTOXicology Knowledgebase (ECOTOX, www.epa.gov/ecotox) is the world’s largest compilation of ecological toxicity data that has been curated over 30 years to support chemical assessments and research. Over the last three years, the well-established ECOTOX systematic an...

Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS), is a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species. For some species, such as humans, mice, rats, and zebrafish, the EPA has a large amo...