Science Inventory

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This subproduct is a presentation presented at the June 14, 2023 EPA/American Cleaning Institute Workshop

This presentation show the work of EPA researchers which allows risk assessors or fellow scientist to predict the use of a chemical substance simply from that chemical's structure. An evaluation of these models against EPA-reported data is shown. This presenation will be made to ...

The rapid characterization of risk to humans and ecosystems from exogenous chemicals requires information on both hazard and exposure. The U.S. Environmental Protection Agency's ToxCast program and the interagency Tox21 initiative have screened thousands of chemicals in various h...

Material extrusion 3D printing has been widely used in industrial, educational and residential environments, while its exposure health impacts have not been well understood. High levels of ultrafine particles are found being emitted from 3D printing and could pose a hazard when i...

Evidence suggests that human exposure to airborne particles and associated contaminants, including respiratory pathogens, can persist beyond a single microenvironment. By accumulating such contaminants from air, clothing may function as a transport vector and source of “secondary...

There are 92 thyroid-relevant assay endpoints from the ToxCast/Tox21 project that can be mapped to molecular initiating events (MIEs) within the thyroid adverse outcome pathway (AOP) network. However, a synthesis and interpretation of the data across MIEs and at the tissue level ...

The US EPA is responsible for evaluating thousands of chemicals for the potential risks to humans and ecosystems, which necessitates information on hazard and exposure potential for each chemical. To support chemical decision-making, EPA's Office of Research and Development (ORD)...

Per- and polyfluoroalkyl substances (PFAS) are a diverse class of long-lasting, man-made chemicals that have been used for a variety of industrial and consumer purposes. Long-term exposure to PFAS has been linked to a range of adverse health effects, including immunosuppression a...

Proper selection of analogs for applicability domain (AD) calculations or read across predictions is a subject of intense debate. For example, one can define similarity using a complete set of descriptors (i.e. unsupervised learning) or by using descriptors that appear in a model...

US EPA, under its ExpoCast program, is developing high-throughput (HT) near-field modeling methods to estimate human chemical exposure and to provide real-world context to HT screening hazard data. These novel modeling methods include reverse methods to infer parent chemical expo...

New non-targeted analysis (NTA) technologies and supporting data analysis platforms have proven increasingly effective at identifying emerging contaminants in environmental and biological samples. Once contaminants are identified, effective mitigation strategies rely on the abili...

We categorized 64,413 chemical substances by broad pathways of exposure: consumer, industrial, pesticide, food, pharmaceuticals, and other pathways.&nbsp; These pathway categorizations can be used as a training set for automated read-across of chemical exposure pathways to better...

Human health chemical risk assessment involves consideration of potentially susceptible subpopulations, including pregnant women and developing fetuses. It is estimated that humans and other organisms encounter thousands of artificial chemicals in their environments, few of which...

The rapid characterization of risk to humans and ecosystems from commercial chemicals requires information on both hazard and exposure. The U.S. Environmental Protection Agency&rsquo;s ToxCast program and the interagency Tox21 initiative have screened thousands of chemicals in va...

New approach methodologies (NAM) for assessing chemical hazard are now established, and are being evaluated for inclusion in regulatory decision-making strategies. However, to implement true risk-based decision-making, analogous methods for assessing exposure potential are needed...

Industrial producers and users of per- and polyfluorinated alkyl substances (PFAS) have been a major source of chemical contamination to nearby communities due to historical releases of legacy PFAS. Following the general phase-out of legacy PFAS such as PFOA/PFOS, industrial usag...

Industrial producers and users of per- and polyfluorinated alkyl substances (PFAS) are a major source of chemical contamination to nearby communities due to historical releases of legacy PFAS. Following the general phase-out of legacy PFAS such as PFOA/PFOS, industrial usage has ...

Industrial producers and users of per- and polyfluorinated alkyl substances (PFAS) are a major source of chemical contamination to nearby communities due to historical releases of legacy PFAS. Following the general phase-out of legacy PFAS such as PFOA/PFOS, industrial usage has ...

Non-targeted analysis (NTA) using high-resolution mass spectrometry allows scientists to detect and identify a broad range of compounds in diverse matrices for monitoring exposure and toxicological evaluation without a priori chemical knowledge. NTA methods present an opportunity...

In the real world, individuals are exposed to chemicals from sources that vary over space and time. However, traditional risk assessments based on in vivo animal studies typically use a chemical-by-chemical approach and apical disease endpoints. New approach methodologies (NAMs) ...

Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard and exposure data, called margin...

Background Knowing which environmental chemicals contribute to metabolites observed in humans is necessary for meaningful estimates of exposure and risk from biomonitoring data. Objective Employ a modeling approach that combines biomonitoring data with chemical metabolism informa...

The Air Pollutants Exposure Model (APEX) is a stochastic population-based inhalation exposure model which (along with its earlier version called pNEM) has been used by the U.S. Environmental Protection Agency (EPA) for over 30 years for assessment of human exposure to airborne po...

The rapid characterization of risk to humans and ecosystems from exogenous chemicals requires information on both hazard and exposure. The U.S. Environmental Protection Agency&rsquo;s ToxCast program and the interagency Tox21 initiative have screened thousands of chemicals in var...

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