Science Inventory

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The EPA Transcriptomic Assessment Product (ETAP) is a human health assessment that utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. The reference value represents the dai...

Current estimates of the size of worldwide and domestic chemical inventories are substantial, with increasing trends in future chemical production and release. Relatively few of the chemicals in commerce, as well as those found in the environment, various waste streams, and the h...

The transcriptomic-based reference values (TRV) is defined as an estimate of a daily oral dose that is likely to be without appreciable risk of adverse effects following chronic exposure.  The TRV is meant to protect both the exposed individual and population from effects other t...

ICCVAM described recommended criteria and processes for validation and regulatory acceptance of toxicological test methods in a 1997 document titled 'Validation and Regulatory Acceptance of Toxicological Test Methods'. Advancements in technologies and tools available for toxicity...

A notable transformation is occurring across the US, Canada, and the globe, reframing “ecosystem restoration” as more than technical actions that improve the environment, but also as collective actions that explicitly acknowledge and include the human and social syste...

This report highlights the salient findings from SHC products contributed by a team of ORD investigators from PHITD and CPAD of CPHEA, CCED of CCTE, and ORISE. The SHC research focused on the influences of maternal exposure to chemical and non-chemical stressors, and their intera...

FY22 User Guide: Periodical updates are required for the ECOTOX end user documentation. This User Guide provides documentation on utilizing and searching for information in the ECOTOX Knowledgebase to help users easily retrieve information from the electronic database through the...

This AOP describes the sequence of events leading from deiodinase inhibition to increased mortality via reduced posterior swim bladder inflation. Disruption of the thyroid hormone system is increasingly being recognized as an important toxicity pathway that can cause ma...

This AOP describes the sequence of events leading from deiodinase inhibition to increased mortality via reduced anterior swim bladder inflation. Disruption of the thyroid hormone system is increasingly being recognized as an important toxicity pathway that can cause man...

This AOP describes the sequence of events leading from deiodinase inhibition to increased mortality via reduced posterior swim bladder inflation. Thyroid hormones (THs) are critical during embryonic development and disruption of the TH system can interfere with normal d...

This AOP describes the sequence of events leading from deiodinase inhibition to increased mortality via reduced anterior swim bladder inflation. Thyroid hormones (THs) are critical during development and disruption of the TH system can interfere with normal development....

This AOP describes the sequence of events leading from thyroperoxidase inhibition to increased mortality via reduced anterior swim bladder inflation. The enzyme thyroperoxidase (TPO) is essential for the synthesis of thyroxine (T4) and triiodothyronine (T3) in the thyro...

Standardized aquatic toxicity test guidelines provide defensible data for use in ecological risk assessments. However, constraints imposed by these assay designs limit the number of tests that can be conducted and inefficiently consume test chemical. To increase throughput and im...

To supplement or replace the existing toxicity tests used to support pesticide registration, EPA’s OPP is actively engaged in numerous activities with respect to reducing laboratory animal use and implementing new approach methodologies (NAMs). NAM is a broad term referring...

Appendix E provides an overview of a five year ORD research effort, aimed at developing approaches and tools that can be used to predict or detect biological activities associated with contaminants of emerging concern in the Great Lakes Basin, provide insights into their sources,...

Under Action Plan II (2015-2019) of the Great Lakes Restoration Initiative (GLRI), Federal and Academicpartners continued an investigation that began under Action Plan I (2010-2014) into the presence anddistribution of contaminants of emerging concern (CECs) in the Great Lakes, a...

In January 2018, ICCVAM published A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States. The roadmap described how ICCVAM agencies will encourage development of new technologies for, support utilizatio...

Reducing the use of mammals and other laboratory animals for toxicity testing is a priority for the U.S. Environmental Protection Agency (EPA) and, as such, the Agency is working on the development and application of New Approach Methodologies (NAMs).  NAMs are defined as an...

Short user manual to guide an user on how to operate GenRA Version 3

A Proof-of-Concept Case Study Integrating Publicly Available Information to Screen Candidates for Chemical Prioritization under TSCA

Shipping of goods and commodities is one of the dominant uses of the Great Lakes. Navigation channels in rivers and harbors must be routinely dredged to mandated depths to facilitate this shipping. In practice, there has been a long-term use of open lake disposal or placement in ...

The ECOTOX Knowledgebase is a comprehensive, publicly available application providing chemical environmental toxicity data on aquatic life, terrestrial plants and wildlife. ECOTOX data has been compiled over more than 30 years and currently includes over 51,000 references coverin...

The fish-community objective is to prevent the introduction of any non-indigenous aquatic species that is not currently established in Lake Superior, prevent or delay the spread of non-indigenous aquatic species, where feasible, and eliminate or reduce populations of nonindigenou...

The Lake Superior ecosystem, while near-pristine in comparison to the other Laurentian Great Lakes, has seen significant biological changes over the past two decades. Starting in the mid-2000s, pelagic prey fish biomass has been declining in both nearshore and offshore waters (Vi...

The Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Standard Operating Procedure (SOP) has been developed to test all current functionality of SeqAPASS tool. It can be used at any time during development, however it is most critical when testing the code up...