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EPA has finalized the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts. This assessment addresses the potential cancer and noncancer human health effects from exposure to PFDA and related salts. EPA’s program and regional offices may use this assessmen...

In July 2024, EPA finalized the IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts. The Toxicological Review was reviewed internally by EPA and by other federal agencies and White House Offices after public release in April 2023. Consistent with the May ...

The National Nanotechnology Initiative organized a Nanoinformatics Conference in the 2023 Biden-Harris Administration’s Year of Open Science, which included interested U.S. and EU stakeholders, and preceded the U.S.-EU COR meeting on November 15th, 2023 in Washington, D.C. Progre...

Concerns about the safety of manufacturing and using engineered nanomaterials (ENMs) have been increasing as the technology continues to expand. Efforts have been underway to investigate the potentially harmful effects of ENMs without carrying out the challenging empirical studie...

Background: The U.S. Federal Government has supported the generation of extensive amounts of nanomaterials and related nano Environmental Health and Safety (nanoEHS) data, there is a need to make these data available to stakeholders. With recent efforts, a need for improved inter...

Terrestrial organisms and ecosystems are being exposed to new and rapidly changing combinations of solar UV radiation and other environmental factors because of ongoing changes in stratospheric ozone and climate. In this Quadrennial Assessment, we examine the interactive effects ...

Metals and metalloids are widely used in producing plastic materials as fillers and pigments, which can be used to track the environmental fate of real-life nanoplastics in environmental and biological systems. Therefore, this study investigated the metal and metalloids concentra...

Microplastic contamination raises concerns in drinking water quality due to difficulties in removing them during treatment and potential for contaminant leaching. EPA’s Office of Research and Development is interested in developing sampling and analytical methods for microp...

Agricultural soils are increasingly undergoing inadvertent and purposeful exposures to engineered CeO2 nanoparticles (NPs), which can impact crops and root-associated microbial communities. However, interactions between NP concentration and exposure duration on plant-mediate...

In April 2023, the IRIS Program released the draft IRIS Toxicological Review of Perfluorodecanoic Acid (PFDA) and Related Salts for public comment and external peer review. The IRIS assessment of PFDA will undergo an independent external scientific peer review managed by ERG, a c...

Plastic particles are now found ubiquitously in the environment. As the abundance of plastic increases in marine systems, the magnitude of adverse biological and ecological effects of plastics of various size classes (macro-, micro-, nano-) need to be evaluated for potential risk...

Per- and polyfluoroalkyl substances (PFAS) are a group of man-made chemicals that have been in use since the 1940s in a wide array of consumer products. PFAS are persistent in the environment and bioaccumulate. Thermal treatment methods are currently applied to a variety of mater...

The use and production of engineered nanomaterials have grown rapidly over the past few decades due to their unique properties and versatility.  However, the full extent of nanomaterials’ impact on the environment is currently unknown.  In this study, we use the W...

With the advancement of nanotechnology, nanoparticles are widely used in many different industrial processes and consumer products. Copper nanoparticles (Cu NPs) are among the most toxic nanomaterials. We investigated Cu NPs toxicity in Human Hepatocellular carcinoma (HepG2) cell...

Persistent organic pollutants (POPs) such as Polychlorinated biphenyls (PCBs) are notorious for their widespread prevalence in aquatic and sedimentary ecosystems, recalcitrance, and carcinogenicity. Dredging and land-filling are still commonly used for treating PCB contaminated m...

Plastic particles are found ubiquitously in the environment, and as plastic abundance increases in marine systems, the adverse biological and ecological effects of plastics of various size classes (macro-, micro-, nano-) needs to be evaluated for potential risks. Marine sediments...

The objective of this research was to perform a genomics study of five cerium oxide particles, 4 nano and one micrometer-sized particles which have been studied previously by our group with respect to cytotoxicity, biochemistry and metabolomics. Human liver carcinoma HepG2 c...

There is an increasing volume of nano-enabled materials in the market. Once composites containing nano-additives are disposed of, weathering could deteriorate their structures, releasing nanoparticles and risking exposure of humans and aquatic organisms. Composite degradation due...

In order to understand toxicity of nano silver, human hepatocellular carcinoma (HepG2) cells were treated either with silver nitrate (AgNO¿) or with nano silver capped with glutathione (Ag-S) at various concentration. Differentially expressed genelists for mRNA and microRN...

Complex interactions of chemical and physical properties with environmental and biological factors greatly affect the behavior including fate and transport of Engineered Nanomaterials, ENMs.  The increasing number of consumer products containing nanomaterials are exponential...

Polylactic acid (PLA) filaments are widely used in fused filament fabrication (FFF) processes (3D printing). Filament additives such as metallic particles incorporated into PLA to modify functional and aesthetic features of print objects are becoming increasingly popular. However...

Presentation on method and monitoring development that involves the detection, speciation, and identification of emerging contaminants, including nanomaterials and micro/nanoplastics, in various media. Discussion will focus on current work analyzing micro and nanoplastics which i...

Although a considerable knowledge base exists for environmental contamination from nanoscale and colloidal particles, significant knowledge gaps exist regarding the sources, transport, distribution, and effects of microplastic pollution (plastic particles < 5 mm)...

Presentation focuses on current challenges and strategies for evidence integration in risk assessment, including comprehensive source to outcome characterization and using AEP and AOP frameworks to create a conceptual mechanistic scaffold by which to evaluate and integrate NAMs i...

Biochar is one of the promising adsorbents for phosphorus remediation, as well as heavy metal removal from contaminated water. It is a solid material, prepared from biomass, like wood waste, by low temperature (< 700¿C) pyrolysis under a limited supply of oxygen. In this study, b...