Science Inventory

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The Regional Monitoring Program for Water Quality in San Francisco Bay (RMP) uses a multi-faceted strategy for cost-effective emerging contaminant identification and monitoring prioritization to support management efforts. As part of this strategy, the RMP is adopting use of nove...

Aquatic organisms are exposed to mixtures of chemicals throughout their life cycle. Understanding the immediate and longer-term effects of mixture exposures is complicated. This is further complicated by the potential for mixture exposures to alter the epigenomes of exposed organ...

The global regulatory landscape surrounding chemical safety is shifting away from animal testing and moving toward greater reliance on New Approach Methodologies (NAMs) including a rapid growth in molecular data and computational methods to achieve human and environmental protect...

Presentation of the status of GLTED's eco-HTP research with PFAS.  Given as part of a meeting/informational exchange with representatives from MN MDH, DNR, and MPCA.

 Background and Purpose Disinfection byproducts (DBPs) are chemical compounds that form when disinfectants like chlorine, chloramine, or ozone react with organic and inorganic materials present in water. While disinfection is critical for protecting public health by eliminat...

Background and Purpose The EPA initiated the Endocrine Disruption Screening Program (EDSP) to identify chemicals interfering with the estrogen, androgen, and thyroid pathways in humans and wildlife. To modernize testing under the EDSP, EPA scientists devised computational models ...

Presentation to the American Society for Cellular and Computational Toxicology (ASCCT) Webinar on HTTr Technologies May 16, 2025  

The global regulatory landscape surrounding chemical safety is shifting away from animal testing and moving toward greater reliance on New Approach Methodologies (NAMs) including a rapid growth in molecular data and computational methods to achieve human and environmental protect...

Modernization of chemical safety evaluations with more efficient and rapid, yet scientifically sound, approaches to protect human and ecological health are necessary to keep pace with the development of new chemicals. Historically and with the advent of high-throughput approaches...

Background: With thousands of chemicals in commerce and the environment, rapid identification of potential hazards is a critical need. Combining broad molecular profiling with targeted in vitro assays, such as high-throughput transcriptomics (HTTr) and receptor scr...

Each year, as the sheer amount of chemicals readily available to the market increases, so does the need for short-term and cost effective high-throughput assays that can be used to evaluate chemical potency and infer potential hazards to human health and/or ecosystems. Over the p...

6PPD-quinone (N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone), a transformation product of the antiozonant 6PPD (N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine) is a likely causative agent of coho salmon (Oncorhynchus kisutch) pre-spawn mortality. Stormwater runof...

6PPD-quinone, a degradation product of the rubber antiozonant 6PPD that is frequently added to tires, has previously been identified as a causative agent of urban runoff mortality syndrome in salmonids. Previous high-throughput phenotypic profiling (HTPP) studies using the Cell P...

The US Environmental Protection Agency is evaluating the ecological and toxicological effects of per- and polyfluoroalkyl substances (PFAS). A number of PFAS have been shown to impact the thyroid axis in vivo suggesting that the thyroid system is a target of these chemicals. The ...

High-throughput screening (HTS) assays allow for rapidly testing many chemicals for bioactivity at specific molecular targets. One goal of HTS is to reduce the time and cost of generating data to support evaluation of chemicals for potential endocrine disruption. Data from these ...

Contaminants of emerging concern (CECs) have been detected in surface waters around the globe, including within the Great Lakes (USA) basin, exposing aquatic biota to a diversity of anthropogenic chemical mixtures. Prioritization of CECs for monitoring and management depend on av...

Multiple in vitro high-throughput screening (HTS) assays have been developed to screen large chemical libraries. The extent to which these HTS assays are indicative of an in vivo impact is unknown. An evaluation was done to determine whether data from currently available thyroid ...

Sample processing is still a serious bottleneck in rapid and timely analysis of a large number of samples resulting in the delayed decision-making during a response to a wide-area biothreat incident. Sponge-Stick is the most commonly used and most preferred surface sampling tool ...

Poster presented to the Society of Toxicology (SOT) 62nd Annual Meeting March 2023. The US Environmental Protection Agency is evaluating the ecological and toxicological effects of per- and polyfluoroalkyl substances (PFAS).  A number of PFAS have been shown to impact t...

Presentation to the SETAC North America meeting November 2022. Application of powerful computational methods used in drug design and development to inform chemical safety decisions relevant to ecotoxicology would have seemed relatively far-fetched 60 years ago. With advances in s...

Poster presented to SETAC North America meeting November 2022. Per- and polyfluoroalkyl substances (PFAS) are ubiquitously detected in the environment. However, with the exception of a few well studied PFAS, hazard data required to evaluate risks that various PFAS pose to aquatic...

Many chemicals found in the environment and commerce have been characterized using in vitro screening for potential hazards. This screening identifies in vitro concentrations resulting in bioactivity that can provide an indicator of hazard for chemicals lacking in vivo toxicologi...

Translation of in vitro points of departure (PODs) to more traditional risk assessment concepts requires quantitative in vitro-in vivo extrapolation (QIVIVE) based upon toxicokinetics (TK). Single chemical methods for QIVIVE have been thoroughly developed by the pharmaceutical in...

Background and Purpose The identification of chemicals with the potential to disrupt estrogen signaling is a key component of the EPA’s Endocrine Disruption Screening Program (EDSP). EPA researchers have worked to devise in vitro assays and computational models to serve as ...

Background and Purpose: Physiological features relevant to toxicokinetics (TK) vary between individuals, but also within a single individual over time. As such, a single measurement of an individual's physiology is not representative of their entire life. In order to more accurat...