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Targeted and Non-targeted Analytical Methods for PFAS Detection and Quantification In Environmental Matrices (June 2023)
(PRESENTATION) [Presented : Jun 20, 2023]
(PRESENTATION) [Presented : Jun 20, 2023]
EPA has developed a suite of targeted analytical methods for measurement of PFAS in waters, soils, sediments and biosolids for regulatory and research applications. Quantification at sub part per trillion levels is possible with capable instrumentation, by selection of an appropr...
Screening Chemicals Using High-Throughput Phenotypic Profiling (HTPP) in Two Zebrafish Cell Lines
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Presentation to SOT Conference 2024: A New Approach Method (NAM) to Screen for the Impact of Endogenous Stress on Chemical Toxicity
A screening level risk assessment of metal and organic contaminants in the Everglades National Park, Biscayne National Park and Big Cypress National Preserve (South Florida, USA)
(PRESENTATION) [Presented : Mar 07, 2024]
(PRESENTATION) [Presented : Mar 07, 2024]
South Florida is a subtropical environment with diverse ecological and human communities that rely on a complex water system undergoing the costliest restoration in U.S. history. Pesticide and metal input to the aquatic systems of South Florida can impact the capabilities of main...
Connecting Stakeholder Priorities and Desired Environmental Attributes for Wetland Restoration Using Ecosystem Services and a Heat Map Analysis for Communications
(JOURNAL) [Published : Mar 27, 2024]
(JOURNAL) [Published : Mar 27, 2024]
Framing ecological restoration and monitoring goals from a human benefits perspective (i.e., ecosystem services) can help inform restoration planners, surrounding communities, and relevant stakeholders about the direct benefits they may obtain from a specific restoration project....
High-Throughput Phenotypic Profiling of 1470 ToxCast Chemicals in Five Biologically Diverse Human-Derived Cell Lines Using the Cell Painting Assay
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose:
High-throughput phenotypic profiling (HTPP) is a modified Cell Painting assay proposed as a first-tier bioactivity screening tool within a tiered in vitro hazard evaluation strategy using New Approach Methodologies (NAMs). HTPP combines high-content imagin...
Evaluating methods for computing points-of-departure with multi-omics data
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Describes timely work on the comparison of dose-response modeling methods for multiple types of omics data.
Development of a Functional Assay using Human Brain Organoids to Study Developmental Neurotoxicity
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose: Human in vitro models of the developing brain are important for studying neurodevelopment and the potential developmental neurotoxicity (DNT) of environmental and pharmacological compounds. Exposure to these compounds during neurodevelopment can cause adve...
Particulate Matter Research Study in the Guayama and Salinas area of Puerto Rico: Research Updates for January, 2024
(NEWSLETTER ARTICLE) [Published : Mar 27, 2024]
(NEWSLETTER ARTICLE) [Published : Mar 27, 2024]
Members of the Puente Jobos community in Puerto Rico shared with EPA concerns they have about particulate matter in their community and whether the location of the regulatory air monitoring site represents the community's exposure. EPA developed a research study design that invol...
Consumption-Based GHG Inventories for Northeast States: Interim Results
(PRESENTATION) [Presented : Feb 27, 2024]
(PRESENTATION) [Presented : Feb 27, 2024]
At this regular project meeting with the NEWMOA Materials and Climate group, we provide a quick overview of the original consumption-based emissions inventory approach and plan, and then provide some interim results for four states: CT, ME, NY, and VT.
Consumption-Based GHG Inventory for Maine Part 1 - Overview
(PRESENTATION) [Presented : Jan 26, 2024]
(PRESENTATION) [Presented : Jan 26, 2024]
An overview of the consumption-based emission inventory being performed for Maine and other northeast states, with some preliminary results for Maine. Many U.S. states are seeking quantitative information to inform the development of policies and plans to manage their green...
Formaldehyde Measurements in Support of Synergistic TEMPO Air Quality Science (STAQS), Summer 2023
(DATA/SOFTWARE) [Published : Mar 27, 2024]
(DATA/SOFTWARE) [Published : Mar 27, 2024]
This dataset includes continuous formaldehyde measurements made at three field sites in the Long Island Sound region during the summer of 2023. A Picarro G2307 formaldehyde and methane analyzer was run at Rutgers in New Brunswick, NJ and Aerodyne formaldehyde instruments were run...
Geographic Analysis of the Vulnerability of U.S. Lakes to Cyanobacterial Blooms under Future Climate
(JOURNAL) [Published : Jan 01, 2023]
(JOURNAL) [Published : Jan 01, 2023]
Cyanobacteria blooms are an increasing concern in U.S. freshwaters. Such blooms can produce nuisance conditions, deplete oxygen, and alter the food chain, and in some cases they may produce potent toxins, although many factors may modulate the relationships between biomass and to...
Patty's Toxicology: Reproductive and Developmental Toxicology
(BOOK CHAPTER) [Published : Jun 28, 2023]
(BOOK CHAPTER) [Published : Jun 28, 2023]
This chapter provides a practical overview of reproductive and developmental toxicology, with a focus on considerations for human health risk assessment. It provides a brief overview of normal reproduction and development, as well as examples of how toxic agents may impact these ...
Plastic Material Flow and Recycling Research
(PRESENTATION) [Presented : Jan 30, 2024]
(PRESENTATION) [Presented : Jan 30, 2024]
The Office of Research and Development is conducting research on plastic material flows and recycling. This effort represents a progress update, showing the research on the recycling system and the material flow analysis on one slide. The recycling system consists of ...
Sustainable Packaging and PET: U.S. Flows, Material Recovery Facilities, and Recycling Processes
(PRESENTATION) [Presented : Feb 12, 2024]
(PRESENTATION) [Presented : Feb 12, 2024]
Plastic flows through the economy have increased from approximately 2 Mt/year in the 1950’s to 368 Mt in 2019, with prospects for quadrupling further by 2050. A large amount of these plastics is made into packaging, so an emphasis on the sustainability of plastic pack...
Analytical methods for PFAS in environmental media (January 2023)
(PRESENTATION) [Presented : Jan 08, 2023]
(PRESENTATION) [Presented : Jan 08, 2023]
Presentation 01/08/2023 -International Conference on the Remediation and Management of Contaminated Sediments.
Topic: Analytical methods for PFAS in environmental media.
Types of analytical and standard methods.
Drinking Water Sample Methods
Method 537
Method 533
Non-Drinki...
Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers
(JOURNAL) [Published : Oct 23, 2021]
(JOURNAL) [Published : Oct 23, 2021]
Total mercury (THg) has been used as a proxy for methylmercury (MeHg) in whole blood; however, it is unclear if this results in exposure misclassification. We estimated blood MeHg from blood THg measurements using a representative sample of the United States population. National ...
Incorporating Metabolic Competence into High-Throughput Profiling Assays
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose:
The US EPA aims to incorporate non-traditional toxicity testing strategies, referred to as new approach methods (NAMs), into regulatory decision making. The first tier of this strategy is focused on using high-throughput profiling (HTP) assays such as Cel...
Essential and Toxic Elements in Infant Cereal in Brazil: Exposure Risk Assessment
(JOURNAL) [Published : Mar 22, 2024]
(JOURNAL) [Published : Mar 22, 2024]
Infant cereals, one of the first solid foods introduced to infants, have been reported to pose risks to human health because they contain toxic elements and an excess of essential elements. Rice cereal is particularly concerning because it is immensely popular and usually contain...
Engineering a Computable Epiblast for in silico Modeling of Developmental Toxicity (SOT 24)
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose: A virtual embryo may be conceptualized as a compendium of computational systems models that integrate biological systems information with chemical specific information to make predictions about developmental toxicity in a digital twin. A challenge to...
Technoeconomic Assessment of Recycling Routes for Chemicals: A Case Study of n-Hexane
(PRESENTATION) [Presented : Oct 11, 2023]
(PRESENTATION) [Presented : Oct 11, 2023]
The circular economy has become one of the most popular topics in worldwide sustainability research. The imperious necessity of reducing resource consumption and decreasing waste generation has led to the idea of reincorporating materials at the end-of-life (EoL) stage into the p...
Modelled zinc and sediment transport of the Spring River watershed: An evaluation of best management practices for remediation
(PRESENTATION) [Presented : Jun 21, 2023]
(PRESENTATION) [Presented : Jun 21, 2023]
These workshops will be platform to present recent research at EPA as it relates to best practices in site characterization, sample analysis, and suitable treatment technologies for mining, persistent organic pollutants, and microplastics. The first presentation will be expanding...
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms
(JOURNAL) [Published : Jul 08, 2021]
(JOURNAL) [Published : Jul 08, 2021]
Serum concentrations of cholesterol are positively correlated with exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in humans. The associated change in cholesterol is small across a broad range of exposure to PFOA and PFOS. Animal studies general...
Development and Optimization of a High-Throughput Assay for Quantifying Phagocytosis in a Human Neutrophil-Like Cell Line
(PRESENTATION) [Presented : Mar 14, 2024]
(PRESENTATION) [Presented : Mar 14, 2024]
Background and Purpose: Phagocytosis, a central effector function of neutrophils, is essential for proper innate immune defense. When exposed to immunosuppressive pharmaceutical and environmental chemicals, neutrophil phagocytosis may be inhibited, potentially increasing suscepti...
Online PFAS Measurements
(PRESENTATION) [Presented : Mar 13, 2024]
(PRESENTATION) [Presented : Mar 13, 2024]
The presentation reviews technologies using infrared and mass spectrometry. The lack of online techniques that are suitable for PFAS monitoring is shown to indicate that more research is needed in this area.