Office of Research and Development Publications

Search Criteria:

Records with

  • Organization = ORD,
  • Record Type = Publications.
Records 1 to 25 of 75672

Next >>
THREAT ENSEMBLE VULNERABILITY ASSESSMENT- SENSOR PLACEMENT OPTIMIZATION TOOL (TEVA-SPOT) GRAPHICAL USER INTERFACE (PUBLISHED REPORT)
software and manual
THE INFLUENCE OF IODINATED CONTRAST MEDIA ON DISINFECTION BYPRODUCT (DBP) SPECIATION AND MUTAGENICITY (PRESENTATION)
Chlorine remains the most frequently used drinking water disinfectant in the U.S. DBPs (more than 700 identified) are formed when oxidizing disinfectants react with natural organic matter and bromide/iodide in water. Some DBPs are known mutagens, genotoxicants, cytotoxicants, r...
Optimization of metabolic parameters using physiologically based pharmacokinetic (PBPK) modeling and chloroform (CHCl3) vapor-uptake inhalation data in F344 rats (PRESENTATION)
PBPK models are well established frameworks used to describe administration, distribution, metabolism, and excretion (ADME) of xenobiotics. To quantify metabolism, a PBPK model for a volatile compound can be calibrated with closed chamber (i.e., vapor uptake) inhalation data. He...
2,4,6-Tribromophenol disposition and kinetics: effects of dose, route, sex, and species (PRESENTATION)
2,4,6-tribromophenol (TBP, CAS No. 118-79-6) is a naturally-occurring bromophenol that is widely used as a brominated flame retardant and wood antifungal. TBP is found in soil, dust, wild-caught seafood, and humans. TBP in vivo studies of oral and dermal disposition were conducte...
Relative Toxicity to Fish Embryos of Polar and Non-Polar Fractions of Weathered Oil (PRESENTATION)
Many studies on the toxicity of oil spilled into the marine environment focus on the well-known adverse biological effects of non-polar polycyclic aromatic hydrocarbons (PAHs). Increasing evidence suggests that besides PAHs, polar heteroatom-containing (e.g., heterocylic and oxyP...
Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice# (JOURNAL)
The health effects of individual criteria air pollutants have been well investigated. However, little is known about the health effects of air pollutant mixtures that more realistically represent environmental exposures. The present study was designed to evaluate the cardiac eff...
Use of high-throughput enzyme-based assay with xenobiotic metabolic capability to evaluate the inhibition of acetylcholinesterase activity by organophosphorous pesticides (JOURNAL)
The inhibition of acetylcholinesterase (AChE) has pharmaceutical applications as well as neurotoxic effects. The metabolites of some chemicals including organophosphorus compounds become more potent AChE inhibitors compared to their parental compounds. In order to identify the AC...
Effect of particle size on the cytotoxicity of zinc oxide nanoparticles in rat and human intestinal cell models (PRESENTATION)
Zinc oxide nanoparticles (NPs) have several commercial applications ranging from catalysts to semiconductors. ZnO NPs are toxic to bacteria, aquatic organisms and human cells. There is a potential for human oral exposure to ZnO NPs following accidental or intentional ingestion, h...
Whole-Genome Sequencing of Four Campylobacter strains Isolated from Gull Excreta collected from Hobie Beach (Oxnard, CA, USA) (JOURNAL)
Campylobacter spp. are commensal organisms in avian species and are recognized as the leading cause of bacterial foodborne diarrheal disease worldwide. We report the draft genome of two Campylobacter volucris strains, and single isolates of C. lari, and C. jejuni isolated from C...
Assessing the Developmental Toxicity and Developmental Neurotoxicity of 26 Organophosphorus Pesticides Using a Zebrafish (Danio rerio) Larval Assay (PRESENTATION)
The U.S. Environmental Protection Agency is evaluating methods to screen and prioritize organophosphorus (OP) pesticides for developmental toxicity and developmental neurotoxicity (DNT). One of those methods uses larval zebrafish. Developmental toxicity in zebrafish embryos/larva...
In vitro intestinal toxicity of multi-walled carbon nanotubes (PRESENTATION)
Multi-walled carbon nanotubes (MWCNTs) are emerging nanomaterials that are widely used in industrial, engineering, biological and medicinal applications due to their unique physiochemical, optical and electrical properties. The release of these nanomaterials into the environment ...
Computational Modeling of an In Vitro Neural Network – Microelectrode Assay for Neurotoxicity Screening (PRESENTATION)
Computational modeling of structural features of an in vitro assay can provide mechanistic insights into assay data. Here we describe computational modeling of an assay where primary rat cortical cells are grown over a microelectrode array for up to 12 days in vitro (DIV). As the...
Identification of Differentially Expressed Genes (DEGs) and Networks Related to Hepatic Lipid Dysfunction (PRESENTATION)
The Adverse Outcome Pathway (AOP) is a conceptual framework that links a molecular initiating event, through a series of biological level key events, to an adverse outcome relevant to risk assessment. To identify key events related to hepatic lipid dysfunction we identified diffe...
EPANET Multi-Species Extension Software and User’s Manual (DATA)
Software and User's Manual
From remediation to restoration and revitalization: The St. Louis River story (BOOK CHAPTER)
Ongoing contaminated sediment remediation and habitat restoration in Great Lakes Areas of Concerns (AOCs) is guided by goals that are defined by the status of Beneficial Use Impairments (BUI), which conceptually are analogous to ecosystem services (i.e., benefits from nature). Th...
Post-hoc Development of a Quantitative Adverse Outcome Pathway Prediction Model for Lung Cancer (PRESENTATION)
Traditional methods for carcinogenicity testing are resource-intensive and time consuming. The continuous backlog of unexamined compounds has generated interest in the adverse outcome pathway (AOP) concept as a chemical-agnostic tool to prospectively evaluate chemical safety in a...
Impact of Scaling Factor Variation on Pharmacokinetic Outcomes in Pediatric Populations: a Case Study Using Bromodichloromethane (BDCM) (PRESENTATION)
In human PBPK models, extrapolating biotransformation rates from in vitro data requires use of scaling factors, including microsomal content (mg of microsomal protein/g liver, MPPGL), enzyme specific content, and liver mass as a fraction of body weight (FVL). We hypothesized tha...
Identification of Differentially Expressed Genes (DEGs) and Networks Related to Hepatic Lipid Homeostatic Dysfunction Using a Gene Expression Approach (PRESENTATION)
DrugMatrix is a database that contains standardized rodent chemical exposure data from 637 chemicals (mostly drugs), along with differential gene expression data and corresponding associated pathological changes. Using this database, we identified 13 chemical exposure treatments ...
In vitro intestinal toxicity of copper nanoparticles in rat and human cell models (PRESENTATION)
Human oral exposure to copper oxide nanoparticles (NPs) may occur following ingestion, hand-to-mouth activity, or mucociliary transport following inhalation. This study assessed the cytotoxicity of CuO and Cu2O-polyvinylpyrrolidone (PVP) coated NPs and Cu2+ ions in rat (IEC-6) a...
In vitro intestinal toxicity of copper oxide nanoparticles in rat and human cell models (JOURNAL)
Human oral exposure to copper oxide nanoparticles (NPs) may occur following ingestion, hand-to-mouth activity, or mucociliary transport following inhalation. This study assessed the cytotoxicity of CuO and Cu2O-polyvinylpyrrolidone (PVP) coated NPs and Cu2+ ions in rat (IEC-6) a...
THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM) (JOURNAL)
Biotransformation rates extrapolated from in vitro data are used increasingly in human physiologically based pharmacokinetic (PBPK) models. This practice requires use of scaling factors, including microsomal content (mg of microsomal protein/g liver, MPPGL), enzyme specific conte...
The RemediAtion DAta Repository (RADAR) Tool (DATA)
Improving the way in which information is shared amongst decision makers, scientists, and responders, as well as models and decision support systems, is critical to the success of any response or recovery operation. Current data sharing capabilities exist; however, the ability to...
ESA2019 Symposium - Integrating Human Health with Ecosystem Services - Research to Provide Practical Tools for Healthier and More Resilient Communities (PRESENTATION)
The US EPA’s Sustainable and Healthy Communities (SHC) National Research Program has provided $2 million research grants to fund four academic research projects through the Science-To-Achieve-Results(STAR) to carry out community-based research that will foster better unders...
CSS STAR RFA Info webinar on HTTK for Efficient and Robust Chemical Evaluations (PRESENTATION)
Informational slide deck on the STAR RFA on HTTK for Efficient and Robust Chemical Evaluations
Urban green and built infrastructure as a tool to mitigate local air pollution (PRESENTATION)
Summary of EPA research and resources on how green and built infrastructure affects near-road and urban air quality
Next >>