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Toxcast and the Use of Human Relevant In Vitro Exposures: Incorporating High-Throughput Exposure and Toxicity Testing Data for 21st Century Risk Assessments (British Toxicological Society Annual Congress)
Citation:
Thomas, R. Toxcast and the Use of Human Relevant In Vitro Exposures: Incorporating High-Throughput Exposure and Toxicity Testing Data for 21st Century Risk Assessments (British Toxicological Society Annual Congress). British Toxicology Society meeting, Liverpool, UK, April 03 - 05, 2017. https://doi.org/10.23645/epacomptox.5057758
Impact/Purpose:
Presentation at the British Toxicological Society Annual Congress on ToxCast and the Use of Human Relevant In Vitro Exposures: Incorporating high-throughput exposure and toxicity testing data for 21st century risk assessments .
Description:
The path for incorporating new approach methods and technologies into quantitative chemical risk assessment poses a diverse set of scientific challenges. These challenges include sufficient coverage of toxicological mechanisms to meaningfully interpret negative test results, development of increasingly relevant test systems, computational modeling to integrate experimental data, putting results in a dose and exposure context, characterizing uncertainty, and efficient validation of the test systems and computational models. The presentation will cover progress at the U.S. EPA in systematically addressing each of these challenges and delivering more human-relevant risk-based assessments. This abstract does not necessarily reflect U.S. EPA policy.
URLs/Downloads:
DOI: Toxcast and the Use of Human Relevant In Vitro Exposures: Incorporating High-Throughput Exposure and Toxicity Testing Data for 21st Century Risk Assessments (British Toxicological Society Annual Congress)
NEW TECHNOLOGIES FOR 21ST CENTURY RISK ASSESSMENT_BTS_FEB_2017_V1.PDF (PDF, NA pp, 4739.978 KB, about PDF)
OPERATIONALIZING NEW APPROACH METHODS IN RISK ASSESSMENT_BTS_JAN_2017.PDF (PDF, NA pp, 61.716 KB, about PDF)