EPA Science Inventory

Towards a 21st century roadmap for biomedical research and drug discovery: Consensus report and recommendations

Citation:

Langley, G., I. Adcock, F. Busquet, K. Crofton, E. Csernok, C. Giese, T. Heinonen, K. Herrmann, M. Hofmann-Apitius, B. Landesmann, L. Marshall 11, E. McIvor, A. Muotri, F. Noor, K. Schutte, T. Seidle, A. van de Stolpe, H. Van Esch, C. Willett, AND G. Woszczek. Towards a 21st century roadmap for biomedical research and drug discovery: Consensus report and recommendations. DRUG DISCOVERY TODAY. Elsevier Science Ltd, New York, NY, , 1-13, (2016).

Description:

Decades of costly failures in translating drug candidates from preclinical disease models to human therapeutic use warrant reconsideration of the priority placed on animal models in biomedical research. Following an international workshop attended by experts from academia, government institutions, research funding bodies and the corporate and NGO sectors, this consensus report analyses, as case studies, five disease areas with major unmet needs for new treatments. In view of the scientifically driven transition towards a human pathways-based paradigm in toxicology, a similar paradigm shift appears to be justified in biomedical research. There is a pressing need for an approach that strategically implements advanced, human biology-based models and tools to understand disease pathways at multiple biological scales. We present recommendations to help achieve this.

Purpose/Objective:

To discover and develop new therapies, we need 21-century roadmaps for biomedical research based on multiscale human disease pathways, and supported by policy and funding strategies that prioritise human relevance.

URLs/Downloads:

http://www.sciencedirect.com/science/article/pii/S1359644616303907   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 10/29/2016
Completion Date: 10/29/2016
Record Last Revised: 11/07/2016
Record Created: 11/07/2016
Record Released: 11/07/2016
OMB Category: Other
Record ID: 330972

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR COMPUTATIONAL TOXICOLOGY