Office of Research and Development Publications

Maternal Residential Exposure to Agricultural Pesticides and Birth Defects in a 2003 to 2005 North Carolina Birth Cohort

Citation:

Rappazzo, K., J. Warren, R. Meyer, A. Herring, A. Sanders, N. Brownstein, AND Tom Luben. Maternal Residential Exposure to Agricultural Pesticides and Birth Defects in a 2003 to 2005 North Carolina Birth Cohort. BIRTH DEFECTS RESEARCH PART A: CLINICAL AND MOLECULAR TERATOLOGY. John Wiley & Sons, Ltd., Indianapolis, IN, 106(4):240-249, (2016).

Description:

Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. We conducted a case-control study to estimate the associations between a residence-based metric of agricultural pesticide exposure and birth defects. We linked singleton live birth records for 2003-2005 from the North Carolina (NC) State Center for Health Statistics to data from the NC Birth Defects Monitoring Program. Included women had residence at delivery inside NC and infants with gestational ages from 20-44 weeks (n=304,906). Pesticide exposure was assigned using a previously constructed metric, estimating total chemical exposure (pounds of active ingredient) based on crops within 500 meters of maternal residence, specific dates of pregnancy, and chemical application dates based on the planting/harvesting dates of each crop. Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for four categories of exposure (<10th, 10-50th, 50-90th, and >90th percentiles) compared to unexposed. Models were adjusted for maternal race, age at delivery, education, marital status, and smoking status. We observed elevated ORs for congenital heart defects and certain structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems (e.g., OR (95% CI) (highest exposure vs. unexposed) for tracheal esophageal fistula/esophageal atresia = 1.98 (0.69, 5.66), and OR for atrial septal defects: 1.70 (1.34, 2.14)). Our results suggest associations between residential exposure to agricultural pesticides and several birth defects phenotypes.

Purpose/Objective:

In this hypothesis-generating study, we examine associations between individual birth defects in a population from North Carolina (NC) and pesticide exposures during pre-conception and early pregnancy using a metric of pesticide exposure created to balance efficiency with improved quantification of residential proximity to total pesticide applications.

URLs/Downloads:

http://onlinelibrary.wiley.com/doi/10.1002/bdra.23479/full   Exit

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 03/11/2016
Completion Date: 03/11/2016
Record Last Revised: 06/01/2016
Record Created: 05/31/2016
Record Released: 05/31/2016
OMB Category: Other
Record ID: 316170

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT

RESEARCH TRIANGLE PARK NC

ENVIRONMENTAL MEDIA ASSESSMENT GROUP