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An Evaluation of Fish ELS Data: Is it Predictive?
Citation:
NORBERG-KING, T. An Evaluation of Fish ELS Data: Is it Predictive? Presented at Workshop on Development of Alternatives to Chronic Ecotoxicity Tests, Paris, FRANCE, June 07 - 09, 2010.
Impact/Purpose:
As with higher vertebrate animal alternatives, balance between reducing the use of animals in testing without impairing or increasing uncertainty in risk assessment is needed. Testing demands for long-term (chronic) fish toxicity represents the third largest pool of needs following 2-generation mammalian developmental toxicity test (OECD TG 416) for REACh. This talk will present the results of a review of freshwater fish ELS endpoints, and related questions in regard to what is known about the ELS for prediction of ecological hazards.
Description:
As with higher vertebrate animal alternatives, balance between reducing the use of animals in testing without impairing or increasing uncertainty in risk assessment is needed. Testing demands for long-term (chronic) fish toxicity represents the third largest pool of needs following 2-generation mammalian developmental toxicity test (OECD TG 416) for REACh. This talk will present the results of a review of freshwater fish ELS endpoints, and related questions in regard to what is known about the ELS for prediction of ecological hazards.