REGIONAL CARDIAC BLOOD FLOW WITH AIR PARTICLE EXPOSURE
Impact/Purpose:
Particulate air pollution is associated with cardiovascular
morbidity and mortality in epidemiological studies. Our laboratory has pioneered
the development of the ambient particle concentrator as a means to carry out
inhalation toxicological assessments of responses to ambient particles in experimental
animals. The most consistent and reproducible response to concentrated air
particles (CAPs) from the urban air of Boston is the increase in severity of
myocardial ischemia during acute coronary artery occlusion using canine models.
The findings of these studies have a remarkable correspondence to the time
course of myocardial infarction onset in relationship to air particulate levels
in human epidemiological studies. The specific aims are: (1) to assess the
mechanisms by which exposure to ambient particles exacerbates myocardial ischemia
during acute coronary occlusion through assessment of regional myocardial blood
flow; (2) to evaluate the role of the autonomic nervous system in regulation
of regional myocardial blood flow with coronary occlusion and exposure to ambient
particles.
Description:
This proposal offers the unique application
of novel techniques to improve understanding of the mechanisms whereby ambient
particulate exerts
deleterious influences on the heart and circulation. Enhanced ischemia has
broad implications for cardiac morbidity and mortality and therefore studies
of the physiologic mechanisms involved in relationship of this outcome to ambient
particulate exposure are particularly important to EPA.
Record Details:
Record Type:PROJECT(
ABSTRACT
)
Start Date:08/01/2004
Completion Date:07/31/2006
Record ID:
86008
Keywords:
AIR PARTICULATES, INHALATION EXPOSURE, CARDIOVASCULAR, ISCHEMIC HEART DISEASE, MYOCARDIAL INFARCTION, MECHANISMS, CONCENTRATED AIR PARTICLES, CORONARY ARTERY PERFUSION, AND AUTONOMIC NERVOUS SYSTEM.,
Related Organizations:
Role
:OWNER
Organization Name
:BETH ISRAEL DEACONESS MEDICAL CENTER
Citation
:Boston
State
:MA
Zip Code
:2215
Role
:OWNER
Organization Name
:BRIGHAM AND WOMEN'S HOSPITAL, INC.
State
:UT
Project Information:
Approach
:Our studies will employ: 1) the Harvard
Ambient Particulate Concentrator (HAPC), a device that can increase ambient
particle concentrations
up to 30x without changing the physical or chemical characteristics of the
particles; 2) a typical urban aerosol; and 3) large animal models of disease
including myocardial ischemia in canines to simulate the condition of compromised
humans with ischemic heart disease, the primary substrate for adult cardiac
mortality. The animals will be chronically instrumented with catheters for
microsphere injections and sampling as well as telemetry devices to monitor
arterial blood pressure and EKG. Coronary blood flow and pressure will be assessed
in animals with short-term coronary artery occlusion.
Cost
:$473,924.00
Research Component
:Health Effects
Approach
:
Our studies will employ: 1) the Harvard
Ambient Particulate Concentrator (HAPC), a device that can increase ambient
particle concentrations
up to 30x without changing the physical or chemical characteristics of the
particles; 2) a typical urban aerosol; and 3) large animal models of disease
including myocardial ischemia in canines to simulate the condition of compromised
humans with ischemic heart disease, the primary substrate for adult cardiac
mortality. The animals will be chronically instrumented with catheters for
microsphere injections and sampling as well as telemetry devices to monitor
arterial blood pressure and EKG. Coronary blood flow and pressure will be assessed
in animals with short-term coronary artery occlusion.
Cost
:$473,924.00
Research Component
:Air Quality and Air Toxics
Approach
:
Our studies will employ: 1) the Harvard
Ambient Particulate Concentrator (HAPC), a device that can increase ambient
particle concentrations
up to 30x without changing the physical or chemical characteristics of the
particles; 2) a typical urban aerosol; and 3) large animal models of disease
including myocardial ischemia in canines to simulate the condition of compromised
humans with ischemic heart disease, the primary substrate for adult cardiac
mortality. The animals will be chronically instrumented with catheters for
microsphere injections and sampling as well as telemetry devices to monitor
arterial blood pressure and EKG. Coronary blood flow and pressure will be assessed
in animals with short-term coronary artery occlusion.
Cost
:$473,924.00
Research Component
:Particulate Matter
Project IDs:
ID Code
:R831917
Project type
:EPA Grant