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NTP-CERHR EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF 1-BROMOPROPANE
Citation:
Boekelheide, K., S D. PERREAULT, G. P. Daston, R. M. David, U. Luderer, Olshan. AF, W. T. Sanderson, C. C. Willhite, AND S. Woskie. NTP-CERHR EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF 1-BROMOPROPANE. REPRODUCTIVE TOXICOLOGY. Elsevier Online, New York, NY, 18:157-188, (2004).
Description:
The National Toxicology Program (NTP) and the National Institute of Environmetnal Health Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in order to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction, including development, caused by agents to which humans may be exposed. 1-Bromopropane (1-BP) was nominated by NIOSH and selected for evaluation by CERHR based on documented evidence of worker exposures and published evidence of reproductive and developmental toxicity in rodents. 1-BP is used in spray adhesives and as a precision cleaner and degreaser. It may also be used as an intermediate in the synthesis of pharmaceuticals, insecticides, quaternary ammonium compounds, flavors, and fragrances and as a solvent for fats, waxes, or resins. This report is intended to (1) interpret the strength of scientific evidence that a given exposure may pose a hazard to reproduction; (2) provide objective and thorough assessments of the scientific evidence that adverse reproductive/developmental health effects may be associated with exposure; and (3) identify knowledge gaps to help establish research and testing priorities. This report addresses public comments made during review in the Federal Register and is being made publicly available. The expert panel expressed minimal concern for adverse effects on human reproductive and development in situations where exposures were intermittent and well- controlled, but serious concern at the upper end of exposure ranges as may be encountered in poorly controlled spray adhesive applications.