You are here:
NTP-CERHR EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF 2-BROMOPROPANE
Citation:
Boekelheide, K., S D. PERREAULT, G. P. Daston, R. M. David, U. Luderer, Olshan. AF, W. T. Sanderson, C. C. Willhite, AND S. Woskie. NTP-CERHR EXPERT PANEL REPORT ON THE REPRODUCTIVE AND DEVELOPMENTAL TOXICITY OF 2-BROMOPROPANE. REPRODUCTIVE TOXICOLOGY. Elsevier Online, New York, NY, 18:189-217, (2004).
Description:
The National Toxicology Program (NTP) and the National Institute of Environmental Health Sciences (NIEHS) established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in order to provide timely, unbiased, scientifically sound evaluations of human and experimental evidence for adverse effects on reproduction, including development, caused by agents to which humans may be exposed. 2-Bromopropane (2-BP) was nominated by NIOSH and selected for evaluation by CERHR based on documented evidence of worker exposures and published evidence of reproductive and developmental toxicity in both rodents and humans. In the US, 2-BP is a contaminant (<0.1%) of 1-BP which is used in spray adhesives and as a precision cleaner and degreaser. 2-BP may also be used as an intermediate in the synthesis of pharmaceutical dyes and other organic chemicals. In Asia 2-BP has been used as a replacement for chlorofluorocarbon and 1,1,1-trichloroethane. A CERHR Expert Panel met at a public meeting in December 2001 to review the scientific evidence on 2-BP and reach conclusions regarding its potential effects on human reproduction. This report is intended to (1) interpret the strength of scientific evidence that a given exposure may pose a hazard to reproduction; (2) provide objective and thorough assessments of the scientific evidence that adverse reproductive/developmental health effects may be associated with exposure; and (3) identify knowledge gaps to help establish research and testing priorities. This report addresses public comments made during review in the Federal Register and is being made publicly available. The expert panel expressed minimal concern for adverse effects on human reproduction at the low end of known human exposures with an increase to some concern at the upper end.