EPA Science Inventory

NEUROTOXICITY PRODUCED BY DIBROMOACETIC ACID IN DRINKING WATER OF RATS.

Citation:

Moser, V C., P. M. Phillips, K. L. McDaniel, A. Levine, R. C. Sills, B. S. Jortner, AND M. T. Butt. NEUROTOXICITY PRODUCED BY DIBROMOACETIC ACID IN DRINKING WATER OF RATS. TOXICOLOGICAL SCIENCES 79:112-122, (2004).

Description:

This manuscript examines the neurotoxic potential of a commonly found disinfection by-product (DBP), dibromoacetic acid (DBA). While the Safe Drinking Water Act requires evaluation of DBPs for noncancer health effects, surprisingly few have been tested for neurotoxicity. Rats exposed for 6 months to DBA in their drinking water displayed neuromuscular and sensorimotor toxicity along with neuropathological changes in the spinal cord. These studies suggest that neurotoxicity should be considered in the overall hazard evaluation of haloacetic acids.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 04/01/2004
Completion Date: 04/01/2004
Record Last Revised: 12/22/2005
Record Created: 05/20/2004
Record Released: 05/20/2004
Record ID: 83097

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

NEUROTOXICOLOGY DIVISION

NEUROBEHAVIORAL TOXICOLOGY BRANCH