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INTRACELLULAR SIGNALING AND DEVELOPMENTAL NEUROTOXICITY.
Citation:
Kodavanti, PRS. INTRACELLULAR SIGNALING AND DEVELOPMENTAL NEUROTOXICITY. Chapter 8, NH Zawia (ed.), Molecular Neurotoxicology: Environmental Agents and Transcriptional Transduction Coupling. CRC Press LLC, Boca Raton, FL, , 151-182, (2004).
Description:
A book chapter in ?Molecular Toxicology: Transcriptional Targets? reviewed the role of intracellular signaling in the developmental neurotoxicity of environmental chemicals. This chapter covered a number of aspects including the development of the nervous system, role of intracellular signaling in the nervous system development and function, and finally discussed the effects of some known developmental neurotoxicants on intracellular signaling events and the adverse effects. The in vitro and in vivo effects of persistent chemicals were discussed in detail correlating the changes in signal transduction events with the morphology of the nervous system and cognitive function. The conclusion was that understanding the effects of developmental neurotoxicants on intracellular signaling could not only provide the mode of action for the neurotoxic effects, but also provide a biochemical/molecular marker(s) that can be used in hazard identification of untested environmental chemicals.